Sedative but not analgesic α2 agonist tolerance is blocked by NMDA receptor and nitric oxide synthase inhibitors

Anesthesiology

Volumn 95, Issue 1, 2001, Pages 184-191

  Davies, M Frances ^a   Reid, Kristina ^a   Guo, Tian Zhi ^a   Agashe, Geeta S ^a   Amin, Yogen K ^b   Maze, Mervyn ^a,c  

^a STANFORD UNIVERSITY   (United States)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^c CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DEXMEDETOMIDINE; DIZOCILPINE; KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NITRIC OXIDE SYNTHASE INHIBITOR; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; AMINO ACID RECEPTOR BLOCKING AGENT; ANALGESIC AGENT; DIZOCILPINE MALEATE; ENZYME INHIBITOR; HYPNOTIC SEDATIVE AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE;

ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; DRUG EFFECT; DRUG TOLERANCE; HYPNOSIS; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SEDATION; ANIMAL; BODY EQUILIBRIUM; DOSE RESPONSE; DRUG ANTAGONISM; DRUG POTENTIATION; MALE; PAIN ASSESSMENT; REFLEX; SPRAGUE DAWLEY RAT;

ADRENERGIC ALPHA-AGONISTS; ANALGESICS; ANIMALS; DEXMEDETOMIDINE; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; ENZYME INHIBITORS; EXCITATORY AMINO ACID ANTAGONISTS; HYPNOTICS AND SEDATIVES; KETAMINE; MALE; MUSCULOSKELETAL EQUILIBRIUM; NITRIC OXIDE SYNTHASE; NITROARGININE; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, N-METHYL-D-ASPARTATE; REFLEX;

EID: 0034743259     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200107000-00029     Document Type: Article

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