Importance of amine pKa and distribution coefficient in the metabolism of fluorinated propranolol analogs: Metabolism by CYP1A2

Drug Metabolism and Disposition

Volumn 29, Issue 11, 2001, Pages 1389-1395

  Upthagrove, Alana L ^a   Nelson, Wendel L ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DIMETHYLPROPRANOLOL; 1,1,1 TRIMETHYLPROPRANOLOL; 4' HYDROXYPROPRANOLOL; 5' HYDROXYPROPRANOLOL; AMINE; CYTOCHROME P450 1A2; CYTOCHROME P450 2D6; DESHYDROXYPROPRANOLOL; DESHYDROXYTRIFLUOROPROPRANOLOL; DESISOPROPYLPROPRANOLOL; DIFLUOROPROPRANOLOL; FLUORINE DERIVATIVE; N TRIFLUOROETHYLDESISOPROPYLPROPRANOLOL; PROPRANOLOL; PROPRANOLOL DERIVATIVE; TRIFLUOROPROPRANOLOL; UNCLASSIFIED DRUG; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DRUG DERIVATIVE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CATALYSIS; COMPARATIVE STUDY; DEALKYLATION; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG STRUCTURE; LIPOPHILICITY; MICHAELIS MENTEN KINETICS; NONHUMAN; PHYSICAL CHEMISTRY; PKA; PRIORITY JOURNAL; STEREOCHEMISTRY; STEREOISOMERISM; BACULOVIRUS; CHEMISTRY; GENETICS; HUMAN; KINETICS; METABOLISM; PH;

ADRENERGIC BETA-ANTAGONISTS; AMINES; BACULOVIRIDAE; CYTOCHROME P-450 CYP1A2; FLUORINE COMPOUNDS; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; PROPRANOLOL;

EID: 0034740666     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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