메뉴 건너뛰기




Volumn 42, Issue 3, 2000, Pages 165-173

Pathogenesis of osteoporosis and challenges for drug delivery

Author keywords

Anabolic; Drug delivery; Osteoporosis; Therapy

Indexed keywords

BONE; DISEASES; DRUG PRODUCTS; PHARMACODYNAMICS;

EID: 0034739273     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(00)00060-0     Document Type: Article
Times cited : (18)

References (36)
  • 1
    • 0020070562 scopus 로고
    • On aging bone loss
    • Mazess R.B. On aging bone loss. Clin. Orthop. 165:1982;239-252.
    • (1982) Clin. Orthop. , vol.165 , pp. 239-252
    • Mazess, R.B.1
  • 2
    • 0019505458 scopus 로고
    • Differential changes in bone mineral density of the appendicular and axial skeleton with aging: Relationship to spinal osteoporosis
    • Riggs B.L., Wahner H.W., Dunn W.L., Mazess R.B., Offord K.P., Melton L.J. Differential changes in bone mineral density of the appendicular and axial skeleton with aging: Relationship to spinal osteoporosis. J. Clin. Invest. 67:1981;328-335.
    • (1981) J. Clin. Invest. , vol.67 , pp. 328-335
    • Riggs, B.L.1    Wahner, H.W.2    Dunn, W.L.3    Mazess, R.B.4    Offord, K.P.5    Melton, L.J.6
  • 3
    • 0016806139 scopus 로고
    • The loss of bone mineral with aging and its relationship to risk of fracture
    • Smith D.M., Khairi M.R.A., Johnston C.C. Jr. The loss of bone mineral with aging and its relationship to risk of fracture. J. Clin. Invest. 56:1975;311-318.
    • (1975) J. Clin. Invest. , vol.56 , pp. 311-318
    • Smith, D.M.1    Khairi, M.R.A.2    Johnston C.C., Jr.3
  • 4
    • 0022477678 scopus 로고
    • Rates of bone loss in the axial and appendicular skeletons of women: Evidence of substantial vertebral bone loss prior to menopause
    • Riggs B.L., Wahner H.W., Melton III L.J., Richelson L.S., Judd H.L., Offord K.P. Rates of bone loss in the axial and appendicular skeletons of women: evidence of substantial vertebral bone loss prior to menopause. J. Clin. Invest. 77:1986;1487-1491.
    • (1986) J. Clin. Invest. , vol.77 , pp. 1487-1491
    • Riggs, B.L.1    Wahner, H.W.2    Melton L.J. III3    Richelson, L.S.4    Judd, H.L.5    Offord, K.P.6
  • 5
    • 0020509916 scopus 로고
    • Relationship between surface, volume, and thickness of iliac trabecular bone on aging and in osteoporosis: Implications for the microanatomic and cellular mechanism of bone loss
    • Parfitt A.M., Matthews C.H.E., Villaneuva A.R., Kleerekoper M., Frame B., Rao D.S. Relationship between surface, volume, and thickness of iliac trabecular bone on aging and in osteoporosis: implications for the microanatomic and cellular mechanism of bone loss. J. Clin. Invest. 72:1983;1396-1409.
    • (1983) J. Clin. Invest. , vol.72 , pp. 1396-1409
    • Parfitt, A.M.1    Matthews, C.H.E.2    Villaneuva, A.R.3    Kleerekoper, M.4    Frame, B.5    Rao, D.S.6
  • 6
    • 0022406116 scopus 로고
    • The role of three-dimensional trabecular microstructure in the pathogenesis of vertebral compression fractures
    • Kleerekoper M., Villanueva A.R., Stanciu J., Rao D.S., Parfitt A.M. The role of three-dimensional trabecular microstructure in the pathogenesis of vertebral compression fractures. Calcif. Tissue Int. 37:1985;594-597.
    • (1985) Calcif. Tissue Int. , vol.37 , pp. 594-597
    • Kleerekoper, M.1    Villanueva, A.R.2    Stanciu, J.3    Rao, D.S.4    Parfitt, A.M.5
  • 7
    • 0000348680 scopus 로고
    • Suggested sequential mode of control of changes in cell behavior in adult bone remodelling
    • Hattner R., Etker B.N., Frost H.M. Suggested sequential mode of control of changes in cell behavior in adult bone remodelling. Nature. 206:1965;489-490.
    • (1965) Nature , vol.206 , pp. 489-490
    • Hattner, R.1    Etker, B.N.2    Frost, H.M.3
  • 8
    • 0001505618 scopus 로고
    • Dynamics of bone remodeling
    • Boston, MA: Little, Brown
    • Frost H.M. Dynamics of bone remodeling. Bone Biodynamics. 1964;Little, Brown, Boston, MA.
    • (1964) Bone Biodynamics
    • Frost, H.M.1
  • 9
    • 0000800059 scopus 로고
    • Lymphocytes, macrophages and the regulation of bone remodeling
    • W.A. Peck. Amsterdam: Elsevier
    • Baron R., Vignery A., Horowitz M. Lymphocytes, macrophages and the regulation of bone remodeling. Peck W.A. Bone and Mineral Research. 1984;175-243 Elsevier, Amsterdam.
    • (1984) Bone and Mineral Research , pp. 175-243
    • Baron, R.1    Vignery, A.2    Horowitz, M.3
  • 10
    • 0024455644 scopus 로고
    • Bolus injections of recombinant human interleukin-1 cause transient hypocalcemia in normal mice
    • Boyce B.F., Yates A.J.P., Mundy G.R. Bolus injections of recombinant human interleukin-1 cause transient hypocalcemia in normal mice. Endocrinology. 125:1989;2780-2783.
    • (1989) Endocrinology , vol.125 , pp. 2780-2783
    • Boyce, B.F.1    Yates, A.J.P.2    Mundy, G.R.3
  • 11
    • 0019824801 scopus 로고
    • Mean wall thickness and formation periods of trabecular bone packets in idiopathic osteoporosis
    • Darby A.J., Meunier P.J. Mean wall thickness and formation periods of trabecular bone packets in idiopathic osteoporosis. Calcif. Tissue Int. 33:1981;199-204.
    • (1981) Calcif. Tissue Int. , vol.33 , pp. 199-204
    • Darby, A.J.1    Meunier, P.J.2
  • 14
    • 0028080039 scopus 로고
    • Bone mineral density in relation to polymorphism at the vitamin D receptor gene locus
    • Hustmyer F.G., Peacock M., Hui S., Johnston C.C., Christian J. Bone mineral density in relation to polymorphism at the vitamin D receptor gene locus. J. Clin. Invest. 94:1994;2130-2134.
    • (1994) J. Clin. Invest. , vol.94 , pp. 2130-2134
    • Hustmyer, F.G.1    Peacock, M.2    Hui, S.3    Johnston, C.C.4    Christian, J.5
  • 15
    • 0029896877 scopus 로고    scopus 로고
    • Vitamin D receptor gene polymorphisms are not related to bone turnover, rate of bone loss, and bone mass in postmenopausal women: The OFELY study
    • Garnero P., Borel O., Sornay-Rendu E., Arlot M.E., Delmas P.D. Vitamin D receptor gene polymorphisms are not related to bone turnover, rate of bone loss, and bone mass in postmenopausal women: the OFELY study. J. Bone Miner. Res. 11:1996;827-834.
    • (1996) J. Bone Miner. Res. , vol.11 , pp. 827-834
    • Garnero, P.1    Borel, O.2    Sornay-Rendu, E.3    Arlot, M.E.4    Delmas, P.D.5
  • 18
    • 0023665454 scopus 로고
    • Trabecular bone architecture in the pathogenesis and prevention of fracture
    • Parfitt A.M. Trabecular bone architecture in the pathogenesis and prevention of fracture. Am. J. Med. 82:(Suppl. 1):1987;68-72.
    • (1987) Am. J. Med. , vol.82 , Issue.SUPPL. 1 , pp. 68-72
    • Parfitt, A.M.1
  • 19
    • 0021222303 scopus 로고
    • Age-related structural changes in trabecular and cortical bone: Cellular mechanism and biomechanical consequences. (a) Difference between rapid and slow bone loss. (b) Localized bone gain
    • Parfitt A.M. Age-related structural changes in trabecular and cortical bone: cellular mechanism and biomechanical consequences. (a) Difference between rapid and slow bone loss. (b) Localized bone gain. Calcif. Tissue Int. 36:1984;S123-S128.
    • (1984) Calcif. Tissue Int. , vol.36
    • Parfitt, A.M.1
  • 20
    • 0007992877 scopus 로고
    • Bone remodeling in the pathogenesis of osteoporosis
    • Parfitt A.M. Bone remodeling in the pathogenesis of osteoporosis. Med. Times. 109:1981;80-92.
    • (1981) Med. Times , vol.109 , pp. 80-92
    • Parfitt, A.M.1
  • 21
    • 0030039250 scopus 로고    scopus 로고
    • A new model for regulation of bone resorption, with particular reference to the effects of bisphosphonates
    • Parfitt A.M., Mundy G.R., Roodman G.D., Hughes D.E., Boyce B.F. A new model for regulation of bone resorption, with particular reference to the effects of bisphosphonates. J. Bone Miner. Res. 11:1996;150-159.
    • (1996) J. Bone Miner. Res. , vol.11 , pp. 150-159
    • Parfitt, A.M.1    Mundy, G.R.2    Roodman, G.D.3    Hughes, D.E.4    Boyce, B.F.5
  • 22
    • 0342793215 scopus 로고
    • Systemic fibroblast growth factor (FGF-1) prevents bone loss, increases new bone formation, and restores trabecular microarchitecture in ovariectomized rats
    • Dunstan C.R., Garrett I.R., Adams R., Burgess W., Jaye M., Youngs T., Boyce R., Mundy G.R. Systemic fibroblast growth factor (FGF-1) prevents bone loss, increases new bone formation, and restores trabecular microarchitecture in ovariectomized rats. J. Bone Miner. Res. 10:(Suppl.):1995;P279.
    • (1995) J. Bone Miner. Res. , vol.10 , Issue.SUPPL. , pp. 279
    • Dunstan, C.R.1    Garrett, I.R.2    Adams, R.3    Burgess, W.4    Jaye, M.5    Youngs, T.6    Boyce, R.7    Mundy, G.R.8
  • 23
    • 0028026645 scopus 로고
    • Relation between increase in length of hip axis in older women between 1950s and 1990s and increase in age specific rates of hip fracture
    • Reid I.R., Chin K., Evans M.C., Jones J.G. Relation between increase in length of hip axis in older women between 1950s and 1990s and increase in age specific rates of hip fracture. Br. Med. J. 309:1994;508-509.
    • (1994) Br. Med. J. , vol.309 , pp. 508-509
    • Reid, I.R.1    Chin, K.2    Evans, M.C.3    Jones, J.G.4
  • 24
  • 27
    • 0032918414 scopus 로고    scopus 로고
    • Blockade of TGFβ signaling inhibits parathyroid hormone-related protein (PTHrP) secretion by breast cancer cells and the development of bone metastasis
    • Yin J.J., Chirgwin J.M., Dallas M., Grubbs B.G., Massague J., Mundy G.R., Guise T.A. Blockade of TGFβ signaling inhibits parathyroid hormone-related protein (PTHrP) secretion by breast cancer cells and the development of bone metastasis. J. Clin. Invest. 103:1999;197-206.
    • (1999) J. Clin. Invest. , vol.103 , pp. 197-206
    • Yin, J.J.1    Chirgwin, J.M.2    Dallas, M.3    Grubbs, B.G.4    Massague, J.5    Mundy, G.R.6    Guise, T.A.7
  • 29
    • 0024602819 scopus 로고
    • Interleukin-1 and tumor necrosis factor stimulate the formation of human osteoclast-like cells in vitro
    • Pfeilschifter J., Chenu C., Bird A., Mundy G.R., Roodman G.D. Interleukin-1 and tumor necrosis factor stimulate the formation of human osteoclast-like cells in vitro. J. Bone Miner. Res. 4:1989;113-118.
    • (1989) J. Bone Miner. Res. , vol.4 , pp. 113-118
    • Pfeilschifter, J.1    Chenu, C.2    Bird, A.3    Mundy, G.R.4    Roodman, G.D.5
  • 31
    • 0025175587 scopus 로고
    • Possible dissociation of the heparin-binding and mitogenic activities of heparin-binding (acidic fibroblast) growth factor-1 from its receptor-binding activities by site-directed mutagenesis of a single residue
    • Burgess W.H., Shaheen A.M., Ravera M., Jaye M., Donohue P.J., Winkles J.A. Possible dissociation of the heparin-binding and mitogenic activities of heparin-binding (acidic fibroblast) growth factor-1 from its receptor-binding activities by site-directed mutagenesis of a single residue. J. Cell Biol. 111:1990;2129-2138.
    • (1990) J. Cell Biol. , vol.111 , pp. 2129-2138
    • Burgess, W.H.1    Shaheen, A.M.2    Ravera, M.3    Jaye, M.4    Donohue, P.J.5    Winkles, J.A.6
  • 32
    • 0026022241 scopus 로고
    • Structure-function studies of heparin-binding (acidic fibroblast) growth factor-1 using site-directed mutagenesis
    • Burgess W.H., Shaheen A.M., Hampton B., Donohue P.J., Winkles J.A. Structure-function studies of heparin-binding (acidic fibroblast) growth factor-1 using site-directed mutagenesis. J. Cell Biochem. 45:1991;131-138.
    • (1991) J. Cell Biochem. , vol.45 , pp. 131-138
    • Burgess, W.H.1    Shaheen, A.M.2    Hampton, B.3    Donohue, P.J.4    Winkles, J.A.5
  • 33
    • 0028088551 scopus 로고
    • Structure-function studies of FGF-1: Dissociation and partial reconstitution of certain of its biological activities
    • Burgess W.H., Friesel R., Winkles J.A. Structure-function studies of FGF-1: dissociation and partial reconstitution of certain of its biological activities. Mol. Reprod. Dev. 39:1994;56-61.
    • (1994) Mol. Reprod. Dev. , vol.39 , pp. 56-61
    • Burgess, W.H.1    Friesel, R.2    Winkles, J.A.3
  • 35
    • 0029090252 scopus 로고
    • Treatment of postmenopausal osteoporosis with slow-release sodium fluoride. Final update of a randomized controlled trial
    • Pak C.Y., Sakhaee K., Adams-Huet B., Piziak V., Peterson R.D., Poindexter J.R. Treatment of postmenopausal osteoporosis with slow-release sodium fluoride. Final update of a randomized controlled trial. Ann. Intern. Med. 123:1995;401-408.
    • (1995) Ann. Intern. Med. , vol.123 , pp. 401-408
    • Pak, C.Y.1    Sakhaee, K.2    Adams-Huet, B.3    Piziak, V.4    Peterson, R.D.5    Poindexter, J.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.