An orally active antidiabetic vanadyl complex, bis(1-oxy-2-pyridinethiolato)oxovanadium(IV), with VO(S2O2) coordination mode; in vitro and in vivo evaluations in rats

Journal of Inorganic Biochemistry

Volumn 80, Issue 1-2, 2000, Pages 99-105

  Sakurai, Hiromu ^a   Sano, Hiromi ^a   Takino, Toshikazu ^a   Yasui, Hiroyuki ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Antidiabetic vanadyl complex; Bis(1 oxy 2 pyridinethiolato)oxovanadium(IV)

Indexed keywords

ANTIDIABETIC AGENT; BIS(1 OXY 2 PYRIDINETHIOLATO)OXOVANADIUM(IV); STREPTOZOCIN; UNCLASSIFIED DRUG; VANADIUM DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; ELECTRON SPIN RESONANCE; GLUCOSE HOMEOSTASIS; MALE; NONHUMAN; RAT; STREPTOZOCIN DIABETES; STRUCTURE ACTIVITY RELATION;

ADIPOCYTES; ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION; ELECTRON SPIN RESONANCE SPECTROSCOPY; FATTY ACIDS, NONESTERIFIED; HALF-LIFE; HYPOGLYCEMIC AGENTS; INJECTIONS, INTRAVENOUS; INSULIN; MALE; MOLECULAR STRUCTURE; RATS; RATS, WISTAR; VANADATES;

ANIMALIA; OXY;

EID: 0034732828     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0162-0134(00)00045-3     Document Type: Article

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