A new type of orally active insulin-mimetic vanadyl complex: Bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) with VO(S2O2) coordination mode

Chemistry Letters

Volumn , Issue 9, 1999, Pages 913-914

  Sakurai, Hiromu ^a   Sano, Hiromi ^a   Takino, Toshikazu ^a   Yasui, Hiroyuki ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0033474854     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: 10.1246/cl.1999.913     Document Type: Article

References (25)

1. Y. Shechter and S. J. D. Karlish, Nature, 286, 556 (1980).
2. G. R. Dubyyak and A. Kleinzeller, J. Biol. Chem., 255, 5306 (1980).
3. C. E. Heyliger, A, G. Tahiliani, and J. H. McNeil, Science, 227, 1474 (1985).
4. J. Meyerovitch, Z. Farfel, J. Sach, and Y. Shechter, J. biol. Chem., 262, 6658 (1987).
5. F. T. G. Hudson, " Toxicology and Biological Significance," Elsevier Publication Co., New York (1964).
6. H. Sakurai, S. Shimomura, K. Fukuzawa, and K. Ishizu, Biochem. Biophys. Res. Commun., 96, 293 (1980).
7. H. Sakurai, K. Tsuchiya, and M. Komatsu, J. Clin. Biochem. Nutr., 8, 193 (1990).
8. J. H. McNeil, V. G. Yuen, and H. R. Hoveya, J. Med. Chem., 35, 1489 (1992).
9. H. Watanabe, M. Nakai, K. Komazawa, and H. Sakurai, J. Med. Chem., 37, 876 (1994).
10. H. Sakurai, H. Watanabe, H. Tamura, H. Yasui, R. Matsushita, and J. Takada, Inorg. Chim. Acta, 283, 175 (1998).
11. H. Sakurai, K. Fujii, H. Watanabe, and H. Tamura, Biochem. Biophys. Res. Commun., 214, 1095 (1995).
12. S. Fujimoto, K. Fujii, H. Yasui, R. Matsushita, J. Tanaka, and H. Sakurai, J. Clin. Biochem. Nutr., 23, 113 (1997).
13. K. Kawabe, M. Tadokoro, Y. Kojima, Y. Fujisawa, and H. Sakurai, Chem. Lett., 1998, 9.
14. R. Tawa, K. Uchida, J. Taniyama, Y. Kojima. Y. Fujisawa, S. Fujimoto, T. Nagaoka, K. Kanamori, and H. Sakurai, J. Pharm. Pharmacol., 51, 119 (1999).
15. K. Kawabe, T. Suekuni, T. Inada, K. Yamato, M. Tadokoro, Y. Kojima, Y, Fujisawa, and H. Sakurai, Chem. Lett., 1998, 1155.
16. H. Sakurai and A. Tsuji, in "Vanadium in the Environment, Part 2: Health Effects," ed by J. O. Nriagu, John Wiley & Sons, New York (1998), p. 297.
17. H. Sakurai, K. Fujii, S. Fujimoto, Y. Fujisawa, K. Takechi, and H. Yasui, in "Vanadiumu Compounds: Chemistry, Biochemistry, and Therapeutic Applications," ACS Symp. Ser., 711, ed by A. S. Tracy and D. C. Chans, Am. Chem. Soc., (1998) p. 344.
18. R. G. Pearson, J. Am. Chem. Soc., 85, 3533 (1963).
19. H. Sakurai, Z. Taira, and N. Sakai, Inorg. Chim. Acta, 151, 85 (1988).
20. 3, methanol and ethanol, but insoluble in n-butanol. VO(OPT) in 5% acacia suspension is stable
21. M. Nakai, H. Watanabe, C. Fujiwara, H. Kakagawa, T. Satoh, J. Takada, K. Matsushita, and H. Sakurai, Biol. Pharm. Bull., 18, 719 (1995).
22. -5 M epinephrine was then added to the reaction mixture and the resulting solutions were incubated at 37 °C for 3 h. The reactions were stopped by soaking in ice water and the mixtures were centrifuged at 12000 rpm for 1 min. For outer solution of the cells, FFA levels were determined with an FFA kit (Wako Pure Chemicals, Japan).
23. K. Takechi, H. Tamura, K. Yamaoka, and H. Sakurai, Free Rad Res., 26, 483 (1997).
24. K. Yamaoka, Y. Tanigawa, T. Nakagawa, J. Pharmacobio-Dyn., 4, 879 (1981).
25. 1/2a=5.2±1.2 (min).