Hippocampal expression of N-methyl-D-aspartate receptor (NMDAR1) subunit splice variant mRNA is altered by developmental exposure to Pb2+

Molecular Brain Research

Volumn 76, Issue 2, 2000, Pages 299-305

  Guilarte, Tomás R ^a   McGlothan, Jennifer L ^a   Nihei, Michelle K ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Brain; Development; Lead; mRNA; NMDA receptor; Splice variant

Indexed keywords

LEAD; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ALTERNATIVE RNA SPLICING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN DEVELOPMENT; CONTROLLED STUDY; FEMALE; GRANULE CELL; HIPPOCAMPUS; IN SITU HYBRIDIZATION; NEUROTOXICITY; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT;

AGING; ALTERNATIVE SPLICING; ANIMALS; BRAIN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HIPPOCAMPUS; LEAD; LEAD POISONING; RATS; RATS, LONG-EVANS; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER; VARIATION (GENETICS);

EPIDENDRUM VICENTINUM;

EID: 0034728641     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(00)00010-3     Document Type: Article

References (43)

1. M. Alkondon, A.C.S. Costa, V. Radhakrishnan, R.S. Aronstam, E.X. Albuquerque, Selective blockade of NMDA-activated channel currents may be implicated in learning deficits caused by lead, FEBS Lett. 261 (1990) 124-130.
2. L. Altmann, F. Weinsberg, K. Sveinsson, H. Lilienthal, H. Wiegand, G. Winneke, Impairment of long-term potentiation and learning following chronic lead exposure, Toxicol. Lett. 66 (1993) 105-112.
3. J. Blahos, R.J. Wenthold, Relationship between N-methyl-D-aspartate receptor NR1 splice variants and NR2 subunits, J. Biol. Chem. 271 (1996) 15669-15674.
4. A.L. Buller, H.C. Larson, B.E. Schhneider, J.A. Beaton, R.A. Morrisett, D.T. Monaghan, The molecular basis of NMDA receptor subtypes: native receptor diversity is predicted by subunit composition, J. Neurosci. 14 (1994) 5471-5484.
5. P.L. Chazot, F.A. Stephenson, Molecular dissection of native mammalian forebrain NMDA receptors containing the NR1 C2 exon: direct demonstration of NMDA receptors comprising NR1, NR2A, and NR2B subunits within the same complex, J. Neurochem. 69 (1997) 2138-2144.
6. M.D. Ehlers, E.T. Fung, R.J. O'Brien, R.L. Huganir, Splice variant-specific interaction of the NMDA receptor subunit NR1 with neuronal intermediate filaments, J. Neurosci. 18 (1998) 720-730.
7. M.D. Ehlers, W.G. Tingley, R.L. Hugamir, Regulated subcellular distribution of the NR1 subunit of the NMDA receptor, Science 269 (1995) 1734-1737.
8. M.D. Ehlers, S. Zhang, J.P. Bernhardt, R.L. Huganir, Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit, Cell (1996) 745-755.
9. T.R. Guilarte, J.L. McGlothan, Hippocampal NMDA receptor mRNA undergoes subunit specific changes during developmental lead exposure, Brain Res. 790 (1998) 98-107.
10. 3H]-MK-801 binding to the NMDA receptor-gated ionophore, Neurosci. Lett. 148 (1992) 27-30.
11. M. Hollmann, J. Boulter, C. Maron, L. Beasley, J. Sullivan, G. Pecht, S. Heinemann, Zinc potentiates agonist-induced currents at certain splice variants of the NMDA receptor, Neuron 10 (1993) 943-954.
12. D.A. Jett, T.R. Guilarte, Developmental lead exposure alters N-methyl-D-aspartate and muscarinic cholinergic receptors in the rat hippocampus: an autoradiography study, Neurotoxicology 16 (1995) 7-18.
13. D.A. Jett, A.C. Kuhlmann, S.J. Farmer, T.R. Guilarte, Age-dependent effects of developmental lead exposure on performance in the Morris water maze, Pharmacol. Biochem. Behav. 57 (1997) 271-279.
14. S.J. Kendrick, M.A. Dichter, K.S. Wilcox, Characterization of desensitization in recombinant N-methyl-D-aspartate receptors: comparison with native receptors in cultured hippocampal neurons, Mol. Brain Res. 57 (1998) 10-20.
15. H.C. Kornau, L.T. Sckenker, M.B. Kennedy, P.H. Seeberg, Domain interaction between NMDA receptor subunits and the post-synaptic density protein PSD-95, Science 269 (1995) 1737-1740.
16. A.C. Kuhlmann, J.L. McGlothan, T.R. Guilarte, Developmental lead exposure causes spatial learning deficits in adult rats, Neurosci. Lett. 233 (1997) 101-104.
17. T. Kutsuwada, N. Kashiwabuchi, H. Mori, K. Sakimura, E. Kushiya, K. Araki, H. Meguro, H. Masaki, T. Kumanishi, M. Arakawa, M. Mishina, Molecular diversity of the NMDA receptor channel, Nature 358 (1992) 36-41.
18. S.M. Lasley, J. Polan-Curtain, D.L. Armstrong, Chronic exposure to environmental levels of lead impairs in vivo induction of long-term potentiation in rat hippocampal dentate, Brain Res. 614 (1993) 347-351.
19. D.J. Laurie, P.H. Seeberg, Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA, J. Neurosci. 14 (1994) 3180-3194.
20. D.J. Laune, J. Putzke, W. Zieglgänsberger, P.H. Seeberg, T.R. Tölle, The distribution of splice variants of the NMDAR1 subunit mRNA in adult rat brain, Mol. Brain Res. 32 (1995) 94-108.
21. J.W. Lin, M. Wyszynski, R. Madhavan, R. Sealock, J.U. Kim, M. Sheng, Yatiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1, J. Neurosci. 18 (1998) 2017-2027.
22. S.M. Logan, F.E. Rivera, J.P. Leonard, Protein kinase C modulation of recombinant NMDA receptor currents: roles for the C-terminal Cl exon and calcium ions, J. Neurosci. 19 (1999) 974-986.
23. J. Luo, Y. Wang, R.P. Yasuda, A.W. Dunah, B.B. Wolfe, The majority of N-methyl-D-aspartate receptor complexes in adult rat cerebral cortex contain at least three different subunits (NR1/NR2A/NR2B), Mol. Pharmacol. 51 (1997) 79-86.
24. C.J. McBain, M.L. Mayer, N-methyl-D-aspartate receptor structure and function, Physiol. Rev. 74 (1994) 723-760.
25. J.W. McDonald, F.S. Silverstem, M.V. Johnston, MK-801 pretreatment enhances N-methyl-D-aspartate-mediated brain injury and increases brain N-methyl-D-aspartate recognition site binding in rats, Neuroscience 38 (1990) 103-113.
26. H. Monyer, R. Sprengel, R. Schoepfer, A. Herb, M. Higuchi, H. Lomeli, N. Burneashev, B. Sakmann, P.H. Seeberg, Heteromeric NMDA receptors: molecular and functional distinction of subtypes, Science 256 (1992) 1217-1221.
27. K. Moriyoshi, M. Masu, T. Ishii, R. Shigemoto, N. Mizuno, S. Nakanishi, Molecular cloning and characterization of the rat NMDA receptor, Nature 354 (1991) 31-37.
28. S. Nakanishi, Molecular diversity of glutamate receptors and implications for brain function, Science 258 (1992) 597-603.
29. N. Nakanishi, R. Axel, N.A. Schneider, Alternative splicing generates functionally distinct N-methyl-D-aspartate receptors, Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 8552-8556.
30. M.K. Nihei, T.R. Guilarte, NMDAR-2A subunit protein expression is reduced in the hippocampus of rats exposed to Pb during development, Mol. Brain Res. 66 (1999) 42-49.
31. I.A. Omelchenko, C.S. Nelson, J.L. Marino, C.N. Allen, The sensitivity of N-methyl-D-aspartate receptors to lead is dependent upon the receptor subunit composition, J. Pharmacol. Exp. Ther. 278 (1996) 15-20.
32. M.C. Paupard, L.K. Friedman, R.S. Zukin, Developmental regulation and cell-surface expression of N-methyl-D-aspartate receptor splice variants in rat hippocampus, Neuroscience 79 (1997) 399-409.
33. A. Rao, A.M. Craig, Activity regulates the synaptic localization of the NMDA receptor in hippocampal neurons, Neuron 19 (1997) 801-812.
34. A.J. Scheetz, M. Constantine-Paton, Modulation of NMDA receptor function: implications for vertebrate neural development, FASEB J. 8 (1994) 745-752.
35. H. Sugihara, K. Moriyoshi, T. Ishii, M. Masu, S. Nakanishi, Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing, Biochem. Biophys. Res. Commun. 185 (1992) 826-832.
36. T. Takanishi, D. Feldmeyer, N. Suzuki, K. Onodera, S.G. Cull-Candy, K. Sakimura, M. Mishina, Functional correlation of NMDA receptor ε subunits expression with the properties of single-channel and synaptic currents in the developing cerebellum, J. Neurosci. 16 (1996) 4376-4382.
37. W.G. Tingley, K.W. Roche, A.K. Thompson, R.L. Huganir, Regulation of NMDA receptor phosphorylation by alternative splicing of the C-termmal domain, Nature 364 (1993) 70-74.
38. M.L. Vallano, Developmental aspects of NMDA receptor function, Crit. Rev. Neurobiol. 12 (1998) 177-204.
39. S. Vicini, J.F. Wang, J.H. Li, W.J. Zhu, Y.H. Wang, J.H. Luo, B.B. Wolfe, D.R. Grayson, Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors, J. Neurophysiol. 79 (1998) 555-566.
40. M.A. Wilson, S.L. Kinsman, M.V. Johnston, Expression of NMDA receptor subunit mRNA after MK-801 treatment in neonatal rats, Dev. Brain Res. 109 (1998) 211-220.
41. M. Wyszynski, J. Lin, A. Rao, E. Ningh, A.H. Beggs, A.M. Craig, M. Sheng, Competitive binding of α-actinin and calmodulin to the NMDA receptor, Nature 385 (1997) 439-442.
42. A.E. Zaiser, V. Miletic, Prenatal and postnatal chronic exposure to low levels of inorganic lead attenuates long-term potentiation in the adult rat hippocampus in vivo, Neurosci. Lett. 239 (1997) 128-130.
43. R.S. Zukin, M.V.L. Bennett, Alternatively spliced isoforms of the NMDAR1 receptor subunit, TINS 18 (1995) 305-313.