Canonical structures for the hypervariable regions of T cell αβ receptors

Journal of Molecular Biology

Volumn 295, Issue 4, 2000, Pages 979-995

  Al Lazikani, Bissan ^a   Lesk, Arthur M ^b   Chothia, Cyrus ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Immune recognition; Loop conformations

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; BINDING SITE; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BINDING;

EID: 0034723149     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.3358     Document Type: Article

References (35)

1. Standard conformations for the canonical structures of immunoglobulins
2. Human T cell receptor variable gene segment families
3. Mouse T cell receptor variable gene segment families
4. Crystal structure of the β chain of a T cell antigen receptor
5. Thermodynamics of T cell receptor binding to peptide-MHC: Evidence for a general mechanism of molecular scanning
6. 2.9 Å resolution structure of an anti-dinitrophenyl spin label monoclonal antibody Fab fragment with bound hapten
7. Canonical structures for the hypervariable regions of immunoglobulins
8. The outline structure of the T cell αβ receptor
9. Conformations of immunoglobulin hypervariable regions
10. Structural repertoire of the human VH segments
11. Ligand recognition by αβ T cell receptors
12. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using TCR amino acids
13. Crystal structure of the Vα domain of a T cell antigen receptor
14. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2
15. An αβ T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex
16. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen
17. Conformation of the hypervariable region L3 without the key proline residue
18. Structure of a human monoclonal antibody Fab fragment against GP41 of HIV-1
19. The three-dimensional structure of a T-cell antigen receptor VαVβ heterodimer reveals a novel arrangement of the Vβ domain
20. Structure of the Vδ domain of a human γδ T-cell antigen receptor
21. Structural families in loops of homologous proteins: Automatic classification, modelling and application to antibodies
22. Low affinity of peptide-MHC complexes with T cell receptor
23. Conformations of the third hyper-variable region in the VH domain of immunoglobulins
24. The X-ray crystal structure Va2.6Ja38 mouse T cell receptor domain at 2.5 Å resolution: Alternative modes of dimerization and crystal packing
25. The complete 685-kilobase DNA sequence of the human β T cell receptor locus
26. Structural classification of CDR-H3 in antibodies
27. The structural repertoire of the human Vκ domain
28. Framework residue 71 is a major determinant of the position and conformation of the second hyper-variable region in the VH domains of immunoglobulins
29. Atomic structure of an αβ T cell receptor (TCR) heterodimer in complex with an anti-TCR Fab fragment derived from a mitogenic antibody
30. Structural insights into the evolution of an antibody combining site
31. TCR binding to peptide-MHC stabilizes a flexible recognition interface
32. Conformation of complementarity determining region - L1 loop in murine IgGλ light chain extends the repertoire of canonical forms