Synthesis and anticonvulsant activity of novel and potent 6,7- methylenedioxyphthalazin-1(2H)-ones

Journal of Medicinal Chemistry

Volumn 43, Issue 15, 2000, Pages 2851-2859

  Grasso, Silvana ^a   De Sarro, Giovambattista ^c   De Sarro, Angela ^a   Micale, Nicola ^a   Zappalà, Maria ^a   Puja, Giulia ^b   Baraldi, Mario ^b   De Micheli, Carlo ^d  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 AMINOPHENYL) 3,4 DIHYDRO 4 METHYL 3 METHYLCARBAMOYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 4 (4 AMINOPHENYL) 2 BUTYLCARBAMOYL 6,7 METHYLENEDIOXYPHTHALAZIN 1(2H) ONE; 4 (4 AMINOPHENYL) 6,7 METHYLENEDIOXYPHTHALAZIN 1(2H) ONE; ANIRACETAM; ANTICONVULSIVE AGENT; PHTHALAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; REACTION ANALYSIS; SEIZURE; STRUCTURE ACTIVITY RELATION;

ACOUSTIC STIMULATION; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; ANTICONVULSANTS; CELLS, CULTURED; CONVULSANTS; DRUG EVALUATION, PRECLINICAL; ELECTROSHOCK; EXCITATORY AMINO ACID AGONISTS; ISOXAZOLES; KAINIC ACID; MICE; MICE, INBRED DBA; NEURONS; PATCH-CLAMP TECHNIQUES; PENTYLENETETRAZOLE; PHTHALAZINES; PROPIONATES; RECEPTORS, AMPA; RECEPTORS, KAINIC ACID; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034721136     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm001002x     Document Type: Article

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