Opposite effects of halothane on guinea-pig ventricular action potential duration

European Journal of Pharmacology

Volumn 390, Issue 1-2, 2000, Pages 95-101

  Terrenoire, Cécile ^a   Piriou, Vincent ^b   Bonvallet, Robert ^a   Chouabe, Christophe ^a   Espinosa, Leon ^a   Rougier, Oger ^a   Tourneur, Yves ^a  

^a UMR 5578 CNRS Univ   (France)

^b LOUIS PRADEL HOSPITAL   (France)

Author keywords

Action potential; Anaesthetic volatile; Arrhythmia; K(ATP) channel; Myocyte; Patch clamp

Indexed keywords

4 (2 CYANIMINO 1,2 DIHYDROPYRID 1 YL) 2,2 DIMETHYL 6 NITROCHROMENE; GLIBENCLAMIDE; HALOTHANE; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; GUINEA PIG; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE POTENTIAL; HEART MUSCLE REFRACTORY PERIOD; HEART PROTECTION; HEART VENTRICLE; MALE; NONHUMAN; PATCH CLAMP; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; REENTRY ARRHYTHMIA; REPERFUSION INJURY; VOLTAGE CLAMP;

ACTION POTENTIALS; ANESTHETICS, INHALATION; ANIMALS; CHROMANS; GUINEA PIGS; HALOTHANE; HEART; HEART VENTRICLES; MALE; MYOCARDIUM; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; REFRACTORY PERIOD, ELECTROPHYSIOLOGICAL;

EID: 0034712009     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00019-4     Document Type: Article

References (29)

1. ATP channels. Annu. Rev. Physiol. 60:1998;667-687.
2. Belles B., Hescheler J., Trube G. Changes of membrane currents in cardiac cells induced by long whole cell recordings and tolbutamide. Pflügers Arch. 409:1987;582-588.
3. Billman G.E., Englert H.C., Scholkens B.A. HMR 1883, a novel cardioselective inhibitor of the ATP-sensitive potassium channel. Part II: effects on susceptibility to ventricular fibrillation induced by myocardial ischemia in conscious dogs. J. Pharmacol. Exp. Ther. 286:1998;1465-1473.
4. + channels in cardiac ischemia: an endogenous mechanism for protection of the heart. Cardiovasc. Drugs Ther. 3:1993;527-537.
5. Cope D.K., Impastato W.K., Cohen M.V., Downey J.M. Volatile anesthetics protect the ischemic rabbit myocardium from infarction. Anesthesiology. 86:1997;699-709.
6. Friedrich M., Benndorf K., Schwalb M., Hirche H.J. Effects of anoxia on K and Ca currents in isolated guinea pig cardiocytes. Pflügers Arch. 416:1990;207-209.
7. Glantz L., Ginosar Y., Chevion M., Gozal Y., Elami A., Navot N., Kitrossky N., Drenger B. Halothane prevents postischemic production of hydroxyl radicals in the canine heart. Anesthesiology. 86:1997;440-447.
8. ATP) openers in models of myocardial ischemia and reperfusion. Can. J. Physiol. Pharmacol. 75:1997;309-315.
9. Hirota K., Ito Y., Matsuda A., Momose Y. Effects of halothane on membrane ionic currents in guinea-pig atrial and ventricular myocytes. Acta Anaesthesiol. Scand. 33:1989;239-244.
10. Hirota K., Momose Y., Takeda R., Nakanishi S., Ito Y. Prolongation of the action potential and reduction of the delayed outward K+ current by halothane in single frog atrial cells. Eur. J. Pharmacol. 126:1986;293-295.
11. 2+ tolerant ventricular myocytes prepared by preincubation in a «KB Medium» Pflügers Arch. 395:1982;6-18.
12. + channels in the cardiovascular system. J. Cardiovasc. Electrophysiol. 8:1997;1431-1446.
13. Janse M.J., Wit A.L. Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction. Phys. Rev. 69:1989;1049-1169.
14. Kersten J.R., Gross G.J., Pagel P.S., Warltier D.C. Activation of adenosine triphosphate-regulated potassium channels. Mediation of cellular and organ protection. Anesthesiology. 88:1998;495-513.
15. Kiyosue T., Arita M., Muramatsu H., Spindler A.J., Noble D. Ionic mechanisms of action potential prolongation at low temperature in guinea-pig ventricular myocytes. J. Physiol. (London). 468:1993;85-106.
16. + channel. Anesthesiology. 65:1996;A515.
17. Luk H.N., Lin C.I., Wei J., Chang C.L. Depressant effects of isoflurane and halothane on isolated human atrial fibers. Anesthesiology. 69:1988;667-676.
18. Nader-Djalal N., Knight P.R. Volatile anesthetic effects on ischemic myocardium. Curr. Opin. Anaesthesiol. 11:1998;403-406.
19. Nichols C.G., Ripoll C., Lederer W.J. ATP-sensitive potassium channel modulation of the guinea pig ventricular action potential and contraction. Circ. Res. 68:1991;280-287.
20. 2+ channel current in guinea-pig myocytes. J. Physiol. (London). 491:1996;91-103.
21. + conductance of myocardium. J. Pharmacol. Exp. Ther. 265:1993;358-365.
22. ATP channels and 'border zone' arrhythmias: role of the repolarization dispersion between normal and ischaemic ventricular regions. Br. J. Pharmacol. 127:1999;1687-1695.
23. Spindler A.J., Noble S.J., Noble D., LeGuennec J.Y. The effects of sodium substitution on currents determining the resting potential in guinea-pig ventricular cells. Exp. Physiol. 83:1998;121-136.
24. + current in guinea-pig ventricular cardiomyocytes. Am. J. Physiol. 273:1997;H324-H332.
25. ATP channels in guinea-pig ventricular myocytes. Pflügers Arch. 437:1998;155-157.
26. Tosaki A., Hellegouarch A. Adenosine triphosphate-sensitive potassium channel blocking agent ameliorates, but the opening agent aggravates, ischemia/reperfusion-induced injury. Heart function studies in non fibrillating isolated hearts. J. Am. Coll. Cardiol. 23:1994;487-496.
27. ATP and a time-dependent current likely due to potassium accumulation. J. Membr. Biol. 142:1994;337-347.
28. Weigt H.U., Kwok W.M., Rehmert G.C., Turner L.A., Bosnjak Z.J. Voltage dependent effects of volatile anesthetics on cardiac sodium current. Anesth. Analg. 84:1997;285-293.
29. + channel blocker HMR 1883 reduces mortality and ischemia-associated electrocardiographic changes in pigs with coronary occlusion. J. Pharmacol. Exp. Ther. 291:1999;474-481.