Parathyroid hormone-related protein is expressed by transformed and fetal human astrocytes and inhibits cell proliferation

Brain Research

Volumn 868, Issue 2, 2000, Pages 230-240

  Shankar, Pragyna ^a   Wei, Hongbing ^a   Davee, Stephen ^a   Funk, Janet ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Astrocyte; Epidermal growth factor; Parathyroid hormone related protein; Proliferation; Tumor necrosis factor

Indexed keywords

EPIDERMAL GROWTH FACTOR; PARATHYROID HORMONE RELATED PROTEIN; TUMOR NECROSIS FACTOR;

ARTICLE; ASTROCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; DISEASE MARKER; FETUS; GLIA CELL; HUMAN; HUMAN CELL; NERVE CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION;

ASTROCYTES; ASTROCYTOMA; BRAIN NEOPLASMS; CELL DIVISION; EPIDERMAL GROWTH FACTOR; FETUS; HUMANS; PARATHYROID HORMONE-RELATED PROTEIN; PEPTIDE FRAGMENTS; PROTEINS; RECEPTORS, PARATHYROID HORMONE; RNA, MESSENGER; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034705803     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02335-0     Document Type: Article

References (35)

1. A.-B. Abou-Samra H. Jüppner T. Force M.W. Freeman X.-F. Kong E. Schipani P. Urena J. Richards J.V. Bonventre J.T. Potts Jr. H.M. Kronenberg G.V. Segre Expression cloning of a common receptor for PTH and PTHrP from rat osteoblast-like cells Proc. Natl. Acad. Sci. USA 89 1992 2732 2736
2. N. Adachi K. Yamaguchi Y. Miyake S. Honda K. Nagasaki Y. Akiyama I. Adachi K. Abe PTHrP is a possible autocrine growth inhibitor for lymphocytes Biochem. Biophys. Res. Commun. 166 1990 1088 1094
3. O. Arisaka K. Obinata K. Yabuta K. Ishimoto K. Sato Hypercalcemia in cerebral medulloblastoma: pathogenesis of solid tumour-associated hypercalcemia Eur. J. Pediatr. 146 1987 434 436
4. M.L. Brines J.P. Zhang Z. Ling W.M. Philbrick A.E. Broadus Evidence that PTHrP is neuroprotective in vitro and in vivo Bone 23 1998 S198 Abstract
5. M.L. Brines Z. Ling A.E. Broadus PTHrP protects against kainic acid excitotoxicity in rat cerebellar granule cells by regulating L-type channel calcium flux Neurosci. Lett. 274 1999 13 16
6. M.L. Casey M. Mibe P.C. MacDonald Regulation of PTHrP gene expression in human endometrial stromal cells in culture J. Clin. Endo. Met. 77 1993 188 194
7. P.R. Cooper G.N. Budzilovich P.H. Berczeller A. Lieberman A. Battista Metastatic glioma associated with hypercalcemia J. Neurosurg. 39 1974 255 259
8. J.L. Funk E.J.T. Krul A.H. Moser J.K. Shigenaga G.J. Strewler C. Grunfeld K.R. Feingold Endotoxin increases parathyroid hormone-related protein mRNA levels in mouse spleen: mediation by tumor necrosis factor J. Clin. Invest. 92 1993 2546 2552
9. J.L. Funk L.A. Cordaro H. Wei J.B. Benjamin D.E. Yocum Synovium as a source of increased amino-terminal PTHrP expression in rheumatoid arthritis J. Clin. Invest. 101 1998 1362 1371
10. T.A. Guise J.J. Yin S.D. Taylor Y. Kumagai M. Dallas B.F. Boyce T. Yoneda G.R. Mundy Evidence for a causal role of PTHrP in the pathogenesis of human breast cancer-mediated osteolysis J. Clin. Invest. 98 1996 1544 1549
11. V.K. Han A. Smith W. Myint K. Nygard S. Bradshaw Mitogenic activity of EGF on newborn rat astroglia Endocrinology 131 1992 1134 1142
12. H. Hashimoto H. Aino N. Ogawa S. Nagata A. Baba Identification of characterization of PTH/PTHrP receptor in cultured astrocytes Biochem. Biophys. Res. Commun. 200 1994 1042 1048
13. 2+/calmodulin-dependent kinase pathway J. Biol. Chem. 271 1996 28105 28111
14. D.A. Jans G. Hassan Nuclear targeting by growth factors, cytokines, and their receptors: a role in signaling? BioEssays 20 1998 400 411
15. L.B. Lachman D.C. Brown C.A. Dinarello Growth promoting effect of recombinant IL-1 and TNF for a human astrocytoma cell line J. Immunol. 138 1987 2913 2916
16. L.K. McCauley T.J. Rosol J.I. Merryman C.C. Capen PTHrP binding to human T-cell lymphotropic virus type I-infected lymphocytes Endocrinology 130 1992 300 306
17. M. Mangin K. Ikeda A.E. Broadus Structure of the mouse gene encoding PTHrP Gene 95 1990 195 202
18. T. Massfelder P. Dann T.L. Wu R. Vasvada J.-J. Helwig A.F. Stewart Opposing mitogenic and anti-mitogenic actions of PTHrP in vascular smooth muscle cells: a critical role for nuclear targeting Proc. Natl. Acad. Sci. USA 94 1997 13630 13635
19. F. de Miguel J.L. Sarasa O. Lopez-Ferro P. Esbrit Immunohistochemical detection of PTHrP in human astrocytomas J. Histochem. Cytochem. 46 1998 277 279
20. M. Nagane H.L.S. Huang W.K. Cavenee Advances in the molecular genetics of gliomas Curr. Opin. Oncol. 9 1997 215 222
21. M.T.A. Nguyen A.C. Karaplis The nucleus: a target site for PTHrP action J. Cell. Biochem. 70 1998 193 199
22. T. Ono K. Inokuchi A. Ogura Y. Ikawa Y. Kudo S. Kawashima Activity-dependent expression of PTHrP in rat cerebellar granule neuron J. Biol. Chem. 272 1997 14404 14411
23. J.J. Orloff Y. Kats P. Urena E. Schipani R.C. Vasavada W.M. Philbrick A. Behal A.-B. Abou-Samra G.V. Segre H. Jüppner Further evidence for a novel receptor for amino-terminal PTHrP on keratinocytes and squamous carcinoma cell lines Endocrinology 136 1995 3016 3023
24. W.M. Philbrick J.J. Wysolmerski S. Galbraith E. Holt J.J. Orloff K.H. Yang R.C. Vasavada E.C. Weir A.E. Broadus A.F. Stewart Defining the roles of PTHrP in normal physiology Physiolog. Rev. 76 1996 127 173
25. B.A. Reynolds S. Weiss Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system Science 255 1992 1707 1710
26. S.B. Rodan G. Weslowski J. Ianacone M.A. Thiede G.A. Rodan Production of PTH-like peptide in a human osteosarcoma cell line: stimulation by phorbol esters and epidermal growth factor J. Endocrinol. 122 1989 219 227
27. K. Roessler G. Suchanek H. Breitschopf K. Kitz C. Matula H. Lassman W.T. Koos Detection of TNFα protein and mRNA in human glial brain tumors J. Neurosurg. 83 1995 291 297
28. H. Sang O.D. Espiritu P.Y. Kelley M.R. Klauber J.D. Hatton The role of EGF in human gliomas. I. The control of cell growth J. Neurosurg. 82 1995 841 846
29. R. Schober A. Waha G. Reifenberger W. Wechsler A. von Deimling O.D. Wiester M. Westler M. Westphal J.T. Kemshead F. Vega J.-Y. Delatre P. Stasiecki-Steinfeld The epidermal growth factor receptor in glioblastoma: genomic amplification, protein expression, and patient survival data in a therapeutic trial Clin. Neuropathol. 14 1995 169 174
30. K.W. Selmaj M. Farooq W.T. Norton C.S. Raine C.F. Brosnan Proliferation of astrocytes in vitro in response to cytokines J. Immunol. 144 1990 129 135
31. G. Struckhoff A. Turzynski Demonstration of PTHrP in meninges and its receptor in astrocytes: evidence for a paracrine meningo–astrocytic loop Brain Res. 676 1995 1 9
32. C.R. Trout T. Sherman S. Reichlin J.L. Funk Parathyroid hormone-related protein: a previously unrecognized neuroimmunomodulator J. Invest. Med. 45 1997 109A
33. D.R. Weaver J.D. Deeds K. Lee G.V. Segre Localization of PTHrP and PTH/PTHrP receptor mRNAs in rat brain Molec. Brain Res. 28 1995 296 310
34. E.C. Weir M.L. Brines K. Ikeda W.J. Burtis A.E. Broadus R.J. Robbins PTHrP gene is expressed in the mammalian central nervous system Proc. Natl. Acad. Sci. USA 87 1990 108 112
35. J.J. Wysolmerski A.F. Stewart The physiology of parathyroid hormone-related protein: an emerging role as a developmental factor Annu. Rev. Physiol. 60 1998 431 460