CGS 34043: A non-peptidic, potent and long-acting dual inhibitor of endothelin converting enzyme-1 and neutral endopeptidase 24.11

Life Sciences

Volumn 67, Issue 9, 2000, Pages 1025-1033

  Trapani, Angelo J ^a   De Lombaert, Stéphane ^a   Beil, Michael E ^a   Bruseo, Charles W ^a   Savage, Paula ^a   Chou, Mary ^a   Jeng, Arco Y ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

CGS 34043; Endothelin converting enzyme; Metalloproteases; Neutral endopeptidase 24.11

Indexed keywords

[2 DIBENZOFURAN 3 YL 1 (1H TETRAZOL 5 YL)ETHYLAMINO]METHYL PHOSPHONIC ACID; CGS 34043; CGS 34753; ENDOTHELIN CONVERTING ENZYME; ENDOTHELIN CONVERTING ENZYME INHIBITOR; MEMBRANE METALLOENDOPEPTIDASE; METALLOPROTEINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; KIDNEY DISEASE; MALE; NONHUMAN; PRESSOR RESPONSE; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ASPARTIC ENDOPEPTIDASES; ATRIAL NATRIURETIC FACTOR; BLOOD PRESSURE; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIN-1; ENDOTHELINS; ENZYME INHIBITORS; HUMANS; KIDNEY CORTEX; MALE; METALLOENDOPEPTIDASES; NEPRILYSIN; PHOSPHONIC ACIDS; PRODRUGS; PROTEIN PRECURSORS; RATS; RATS, SPRAGUE-DAWLEY; TETRAZOLES;

ANIMALIA;

EID: 0034698408     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(00)00695-0     Document Type: Article

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