Endotoxin-induced microvascular leakage is prevented by a PAF antagonist and no synthase inhibitor

Shock

Volumn 7, Issue 1, 1997, Pages 49-54

  Laniyonu, Adebayo A ^a   Coston, Anthony F ^a   Klabunde, Richard E ^a  

^a DEBORAH HEART AND LUNG CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; ENDOTOXIN; LIPOPOLYSACCHARIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; THROMBOCYTE ACTIVATING FACTOR;

ANIMAL; ARTICLE; BLOOD FLOW VELOCITY; CELL ADHESION; DRUG ANTAGONISM; DRUG EFFECT; HAMSTER; MALE; MICROCIRCULATION; SYRIAN HAMSTER;

ANIMALS; BLOOD FLOW VELOCITY; CELL ADHESION; CRICETINAE; DEXAMETHASONE; ENDOTOXINS; LIPOPOLYSACCHARIDES; MALE; MESOCRICETUS; MICROCIRCULATION; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PLATELET ACTIVATING FACTOR;

EID: 0030635939     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-199701000-00006     Document Type: Article

References (39)

1. Parrillo JE: Pathogenetic mechanisms of septic shock. N Eng J Med 328:1471-1477, 1993.
2. Giroir BP: Mediators of septic shock: New approaches for interrupting the endogenous inflammatory cascade. Crit Care Med 21:780-789, 1993.
3. Granger DN, Kubes P: The microcirculation and inflammation: Modulation of leukocyte-endothelial cell adhesion. J Leukoc Biol 55:662-675, 1994.
4. 4 and the role of polymorphonuclear leukocytes. Inflammation 6:189-200, 1982.
5. Kubes P, Suzuki M, Granger DN: Modulation of PAF-induced leukocyte adherence and increased microvascular permeability. Am J Physiol 259: G859-G864, 1990.
6. Dillon PK, Duran WN: Effect of platelet-activating factor on microvascular permselectivity: Dose-response relations and pathways of action in the hamster cheek pouch microcirculation. Cire Res 62:732-740, 1988.
7. Klabunde RE, Calvello C: Inhibition of endotoxin-induced microvascular leakage by a platelet activating factor antagonist and 5-lipoxygenase inhibitor. Shock 4:368-372, 1995.
8. Kilbourn RG, Griffith OW: Overproduction of nitric oxide in cytokine-mediated and septic shock. J Natl Cancer Inst 84:827-831, 1992.
9. Rees DD, Cellek S, Palmer RMJ, Moncada S: Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: An insight into endotoxin shock. Biochem Biophys Res Commun 173:541-547, 1990.
10. Davidsen SK, Summers JB, Albert DH, Holms JH, Heyman HR, Magoc TJ: N-(acyloxyalkyl)pyridinium salts as soluble prodrugs of a potent platelet-activating factor antagonist. J Med Chem 37:4423-4429, 1994.
11. Suffredini AF, Fromm RE, Parker MM, Brenner M, Kovacs JA, Wesley RA, Parrillo JE: The cardiovascular response of normal humans to the administration of endotoxin. N Eng J Med 321:280-287, 1989.
12. Koltai M, Hosford D, Braquet P: Role of PAF and cytokines in microvascular tissue injury. J Lab Clin Med 119:461-466, 1992.
13. Dillon PK, Fitzpatrick MF, Ritter AB, Duran WN: Effect of platelet activating factor on leukocyte adhesion to microvascular endothelium. Inflammation 12:563-573, 1988.
14. 4-induced neutrophil-mediated endothelial leakage in vitro and m vivo. J Appl Physiol 71:1322-1330, 1991.
15. Matsuda T, Rubinstein I, Robbins RA, Koyama S, Joyner WL, Rennard SI: Role of neutrophils in endotoxin-mediated microvascular injury in hamsters. J Appl Physiol 71:307-313, 1991.
16. Kubes P, Suzuki M, Granger DN: Platelet-activating factor-induced microvascular dysfunction: Role of adherent leukocytes. Am J Physiol 258: G158-G163, 1990.
17. Kurose I, Granger DN, Evans DJ, Jr, et al: Helicobacter pylori-induced microvascular protein leakage in rats: Role of neutrophils, mast cells, and platelets. Gastroenterology 107:70-79, 1994.
18. Harris NR, Benoit JN, Granger DN: Capillary filtration during acute inflammation: Role of adherent neutrophils. Am J Physiol 265:H1623-H1628, 1993.
19. Mulder K, Colditz IG: Migratory responses of ovine neutrophils to inflammatory mediators in vitro and in vivo. J Leukoc Biol 53:273-278, 1993.
20. Harris NR, Granger DN: Mechanisms underlying enhanced capillary filtration induced by platelet-activating factor. Am J Physiol 270:H127-H133, 1996.
21. Kim DY, Duran WN: Platelet-activating factor stimulates protein tyrosine kinase in hamster cheek pouch microcirculation. Am J Physiol 37:H399-H403, 1995.
22. Baydoun AR, Foale RD, Mann GE: Bacterial endotoxin rapidly stimulates prolonged endothelium-dependent vasodilatation in the rat isolated perfused heart. Br J Pharmacol 109:987-991, 1993.
23. Stoclet JC, Fleming I, Gray G, Julou-Schaeffer G, Schneider F, Schott C, Parratt JR: Nitric oxide and endotoxemia. Circulation 87:V77-V80:1993.
24. Yuan Y, Granger HJ, Zawieja DC, DeFily DV, Chilian WM: Histamine increases venular permeability via a phospholipase C-NO synthase-guanylate cyclase cascade. Am J Physiol 264:H1734-H1739, 1993.
25. Mayhan WG: Nitric oxide accounts for histamine-induced increases in macromolecular extravasation. Am J Physiol 266:2369-2373, 1994.
26. Ramiriz MM, Quardt SM, Kim D, Oshiro D, Minnicozzi M, Duran WN: Platelet-activating factor modulates microvascular permeability through nitric oxide synthesis. Microvasc Res 50:223-234, 1995.
27. Kurose I, Wolf R, Grisham MB, Granger DN: Effect of endogenous inhibitor of nitric oxide systhesis on post capillary venule. Am J Physiol 268:H2224-H2231, 1995.
28. Kubes P, Suzuki M, Granger DN: Nitric oxide: An endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 88:4651-4655, 1991.
29. Kubes P: Nitric oxide-induced microvascular permeability alterations: A regulatory role for cGMP. Am J Physiol 34:H1909-H1915, 1993.
30. Hutcheson IR, Whittle BJR, Boughton-Smith NK: Role of nitric oxide in maintaining vascular integrity in endotoxin-induced acute intestinal damage in the rat. Br J Pharmacol 101:815-820, 1990.
31. Salvemini D, Korbut R, Anggard E, Vane JR: Immediate release of nitric oxide-like factor from bovine aortic endothelial cells by Escherichia coli lipopolysaccharide. Proc Natl Acad Sci USA 87:2593-2597, 1990.
32. Wright CE, Rees DD, Moncada S: Protective and pathological roles of nitric oxide in endotoxin shock. Cardiovasc Res 26:48-57, 1992.
33. Bouskela E, Rubanyi GM: Effects of n(W)-nitro-L-arginine and dexamethasone on early events following lipopolysaccharide injection: Observations in the hamster cheek pouch microcirculation. Shock 1:347-353, 1994.
34. G-monomethyl-L-arginine. J Cardiovasc Pharmacol 20:S132-S134, 1992.
35. Oda T, Katori M: Inhibition site of dexamethasone on extravasation of polymorphonuclear leukocytes in the hamster cheek pouch microcirculation. J Leukoc Biol 52:337-342, 1992.
36. 2+-independent nitric oxide synthases. FEBS Lett 291:145-149, 1991.
37. Blackwell GJ, Flower RJ, Nijkamp FP, Vane JR: Phospholipase A2 activity of guinea-pig isolated perfused lungs: Stimulation and inhibition by anti-inflammatory steroids. Br J Pharmacol 62:79-89, 1978.
38. Knudsen PJ, Dinarello CA, Strom TB: Glucocorticoids inhibit transcription and post-transcriptional expression of interleukin-1 in U937 cells. J Immunol 139:4129-4134, 1987.
39. Tahri-Jouti MA, Chaby R: Specific binding of lipipolysaccharide to mouse macrophages. I. Characteristics of the interaction and inefficiency of the polysaccharide region. Mol Immunol 27:751-761, 1990.