Cisplatin-DNA cross-link models with an unusual type of chirality-neutral chelate amine carrier ligand, N,N'-dimethylpiperazine (Me2ppz): Me2ppzPt(guanosine monophosphate)2 adducts that exhibit novel properties

Inorganic Chemistry

Volumn 39, Issue 4, 2000, Pages 836-842

  Sullivan, Sharon T ^a   Ciccarese, Antonella ^b   Fanizzi, Francesco P ^b,c   Marzilli, Luigi G ^a  

^a EMORY UNIVERSITY   (United States)

^b UNIVERSITY OF SALENTO   (Italy)

^c UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIMETHYLPIPERAZINE; ANTINEOPLASTIC AGENT; BIS(GUANOSINE MONOPHOSPHATE)(N,N' DIMETHYLPIPERAZINE)PLATINUM(II); BIS(GUANOSINE MONOPHOSPHATE)(N,N'-DIMETHYLPIPERAZINE)PLATINUM(II); CARRIER PROTEIN; CHELATE; CISPLATIN; CROSS LINKING REAGENT; CROSS LINKING REAGENTS; DNA; DRUG CARRIER; GUANOSINE PHOSPHATE; LIGAND; N,N'-DIMETHYLPIPERAZINE; PIPERAZINE DERIVATIVE; PLATINUM COMPLEX; PLATINUM DERIVATIVE; UNCLASSIFIED DRUG;

1,4 DIMETHYLPIPERAZINE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHIRALITY; CIRCULAR DICHROISM; COMPLEX FORMATION; CONFORMATION; CROSS LINKING; DNA DRUG COMPLEX; DRUG DNA INTERACTION; HYDROGEN BOND; LIGAND BINDING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

5'-GUANYLIC ACID; ANTINEOPLASTIC AGENTS; CIRCULAR DICHROISM; CISPLATIN; CROSS-LINKING REAGENTS; DNA; DRUG CARRIERS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; ORGANOPLATINUM COMPOUNDS; PIPERAZINES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0034695864     PISSN: 00201669     EISSN: None     Source Type: Journal    
DOI: 10.1021/ic9903580     Document Type: Article

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