Role of human n-acetyltransferases, NAT1 or NAT2, in genotoxicity of nitroarenes and aromatic amines in Salmonella typhimurium NM6001 and NM6002

Carcinogenesis

Volumn 20, Issue 6, 1999, Pages 1079-1083

  Oda, Yoshimitsu ^a   Yamazaki, Hiroshi ^a   Shimada, Tsutomu ^a  

^a OSAKA PREFECTURAL INSTITUTE OF PUBLIC HEALTH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; AROMATIC AMINE; BETA GALACTOSIDASE; CARCINOGEN;

ARTICLE; CLONING VECTOR; ENZYME ACTIVITY; FUSION GENE; GENE EXPRESSION; GENOTOXICITY; MOLECULAR CLONING; NONHUMAN; PLASMID; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; TOXICITY TESTING;

ARYLAMINE N-ACETYLTRANSFERASE; BIOTRANSFORMATION; CARCINOGENS; CHRYSENES; FLUORENES; HUMANS; ISOENZYMES; PYRENES; QUINOLINES; SALMONELLA TYPHIMURIUM;

EID: 0033027263     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/20.6.1079     Document Type: Article

References (44)

1. Rosenkranz, H.S. and Mermelstein, R. (1985) The genotoxicity, metabolism and carcinogenicity of nitrated polycyclic aromatic hydrocarbons. J. Environ. Sci. Health, C3, 221-272.
2. Weisburger, J.H. (1988) Past, present and future role of carcinogenic mutagenic N-substituted aryl compounds in human cancer causation. In King, C.M., Romano, L.J. and Schuetzle, D. (eds) Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroarenes. Elsevier, New York, NY, pp. 3-19.
3. Rosenkranz, H.S. and Mermelstein, R. (1983) Mutagenicity and genotoxicity of nitroarenes: all nitro-containing chemicals were not created equal. Mutat. Res., 114, 217-267.
4. Tokiwa, H. and Ohnishi, Y. (1986) Mutagenicity and carcinogenicity of nitroarenes and their sources in the environment. CRC Crit. Rev. Toxicol., 17, 23-60.
5. Garner, R.C., Martin, C.N. and Clayson, D.B. (1984) Carcinogenic aromatic amines and related compounds. In Searle, C.E. (ed.) Chemical Carcinogens. 2nd edn. American Chemical Society Monograph No. 182. American Chemical Society, Washington, DC, Vol. 1, pp. 175-276.
6. Layton, D.W., Bogen, K.T., Knize, M.G., Hatch, F.T., Johnson, U.M. and Felton, J.S. (1995) Cancer risk of heterocyclic amines in cooked foods: an analysis and implications for research. Carcinogenesis, 16, 39-52.
7. Evans, D.P. (1989) N-Acetyltransferase. Pharmacol. Ther., 42, 157-234.
8. Vatsis, K.P. and Weber, W.W. (1994) Human N-acetyltransferase. In Kauffman, F.C. (ed.) Conjugation-Deconjugation Reaction in Drug Metabolism and Toxicity. Handbook of Experimental Pharmacology. Springer-Verlag, Heidelberg, vol 112, pp. 109-130.
9. Vatsis, K.P. and Weber, W.W. (1993) Structural heterogenicity of Caucasian N-acetyltransferase at the NAT1 locus. Arch. Biochem. Biophys., 301, 71-76.
10. Bell, D.A., Badawi, A.F., Lang, N.P. Ilett, K.F., Kadlubar, F.F. and Hirvonen, A. (1995) Polymorphism in the N-acetyltransferase 1 (NAT1) polyadenylation signal: association of NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue. Cancer Res., 55, 5226-5229.
11. Weber, W.W. and Hein, D.W. (1985) N-Acetylation pharmacogenetics. Pharmacol. Rev., 37, 25-79.
12. Hein, D.W. (1988) Acetylator genotype and arylamine-induced carcinogenesis. Biochim. Biophys. Acta, 948, 37-66.
13. Minchin, R.F., Kadluber, F.F. and Ilett, K.F. (1993) Role of acetylation in colorectal cancer. Mutat. Res., 290, 35-42.
14. Vineis, P., Caporaso, N., Tannenbaum, S.R., Skipper, P.L., Glogowski, J., Bartsch, H., Coda, M., Talaska, G. and Kadlubar, F.F. (1990) Acetylation phenotype, carcinogen-hemoglobin adducts and cigarette smoking. Cancer Res., 50, 3002-3004.
15. Yu, M.C., Skipper, P.L., Taghizadeh, K., Tannenbaum, S.R., Chan, K.C., Henderson, B.E. and Ross, R.K. (1994) Acetylator phenotype, aminobiphenyl-hemoglobin adduct levels and bladder cancer risk in White, Black and Asian men in Los Angeles, California. J. Natl Cancer Inst., 86, 712-716.
16. Oda, Y., Yamazaki, H., Watanabe, M., Nohmi, T. and Shimada, T. (1993) Highly sensitive umu test system for the detection of mutagenic nitroarenes in Salmonella typhimurium NM3009 having high O-acetyltransferase and nitroreductase activities. Environ. Mol. Mutagen., 21, 357-364.
17. Oda. Y., Yamazaki, H., Watanabe, M., Nohmi, T. and Shimada, T. (1995) Development of high sensitive umu test system: rapid detection of genotoxicity of promutagenic aromatic amines by Salmonella typhimurium strain NM2009 possessing high O-acetyltransferase activity. Mutat. Res., 334, 145-156.
18. Ono, Y., Somiya, I. and Kawaguchi, T. (1995) Evaluation of genotoxic potency on substances contained in nightsoil and its reduction by ozonation. Ozone Sci. Engng, 17, 195-203.
19. Ono, Y., Somiya, I. and Kawaguchi, T. (1996) Genotoxicity of substances in the nightsoil and its biologically treated water. Water Res., 30, 569-577.
20. Yamazaki, H., Oda, Y. and Shimada, T. (1992) Use of a newly developed tester strain Salmonella typhimurium NM2009 for the study of metabolic activation of carcinogenic aromatic amines by rat liver microsomal cytochrome P-450 enzymes. Mutat. Res., 272, 183-192.
21. Shimada, T., Oda, Y., Yamazaki, H., Mimura, M. and Guengerich, F.P. (1994) SOS function tests for studies of chemical carcinogenesis in Salmonella typhimurium TA1535/pSK1002, NM2009 and NM3009. In Adolph, K.W. (ed.) Methods in Molecular Genetics. Vol. 5, Gene and Chromosome Analysis. Academic Press, Orlando, FL, pp. 342-355.
22. Ames, B.N., Lee, F.D. and Durston, W.E. (1973) An improved bacterial test system for the detection and classification of mutagens and carcinogens. Proc. Natl Acad. Sci., 70, 782-786.
23. Watanabe, M., Ishidate, M.Jr and Nohmi, T. (1990) Sensitive method for detection of mutagenic nitroarenes: construction of nitroreductase-overproducing derivatives of Salmonella typhimurium TA98 and TA100. Mutat. Res., 216, 211-220.
24. Grant, D.M., Josephy, P.D., Lord, H.L. and Morrison, L.D. (1992) Salmonella typhimurium strains expressing human arylamine N-acetyltransferases: metabolism and mutagenic activation of aromatic amines. Cancer Res., 52, 3961-3964
25. Shinagawa, H., Kato, T., Ise, T., Makino, K. and Nakata, A. (1983) Cloning and characterization of the umu operon responsible for inducible mutagenesis in Escherichia coli. Gene, 23, 167-174.
26. Chang, A.C.Y. and Cohen, S.N. (1978) Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the p15A cryptic miniplasmid. J. Bacteriol., 134, 1141-1156.
27. Maniatis, T., Fritsch, E.F. and Sambrook, J. (1989) Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, NY.
28. Hein, D.W., Hirata, M., Glowinski, I.B. and Weber, W.W. (1982) Biochemical evidence for the co-existence of monomorphic and polymorphic N-acetyltransferase activation on a common protein in rabbit liver. J. Pharmacol. Exp. Ther., 220, 1-7.
29. Andres, H.H., Klem, A.J., Szabo, S.M and Weber, W.W. (1985) New spectrophotometric and radiochemical assays for acetyl-CoA: arylamine N-acetyltransferase applicable to a variety of arylamines. Anal. Biochem., 145, 367-375.
30. Lowry, O.H., Rosenbrough, N.J., Farr, A.L. and Randall, R.J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275.
31. Miller, J.H. (1972) Experiments in Molecular Genetics. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, New York, NY, pp. 352-355.
32. Oda, Y., Nakamura, S., Oki, I., Kato, T. and Shinagawa, H. (1985) Evaluation of the new system (umu-test) for the detection of environmental mutagens and carcinogens. Mutat. Res., 147, 219-229.
33. Minchin, R.F., Reeves, P.T., Teitel, C.H., McManus, M.E., Mojarrabi, B., Ilett, K.F. and Kadlubar, F.F. (1992) N- and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in COS-1 cells. Biochem. Biophys. Res. Commun., 185, 839-844.
34. Grant, D.M. (1993) Molecular genetics of the N-acetyltransferases. Pharmacogenetics, 3, 45-50.
35. Josephy, P.D. (1986) Benzidine: mechanisms of oxidative activation and mutagenesis. Fed. Proc., 45, 2465-2470.
36. Vatsis, K.P. and Weber, W.W. (1993) Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus. Arch. Biochem. Biophys, 301, 71-76.
37. Andrews, P.J., Quilliam, M.A., McCarry, B.E., Bryant, D.W. and McCalla, D.R. (1986) Identification of the DNA adduct formed by metabolism of 1,8-dinitropyrene in Salmonella typhimurium. Carcinogenesis, 7, 105-110.
38. Norman, C.A., Lambert, I.B., Davison, L.M., Bryant, D.W. and McCalla, D.R. (1990) Formation and persistence of DNA adducts in rats following intraperitoneal administration of 1,8-dinitropyrene. Carcinogenesis, 11, 1037-1040.
39. Watanabe, M., Matuoka, A., Yamazaki, N., Hayashi, M., Deguchi, T., Nohmi, T. and Sofuni, T. (1994) New sublines of Chinese hamster CHL stably expressing human NAT1 or NAT2 N-acetyltransferase or Salmonella typhimurium O-acetyltransferase: comparison of the sensitivities to nitroarenes and aromatic amines using the in vitro micronucleus test. Cancer Res., 54, 1672-1677.
40. Wild, D., Feser, W., Michel, S., Lord, H.L. and Josephy, P.D. (1992) Metabolic activation of heterocyclic aromatic amines catalyzed by human arylamine N-acetyltransferase isozymes (NAT1 and NAT2) expressed in Salmonella typhimurium. Carcinogenesis, 16, 643-648.
41. Wu, R.W., Tucker, J.D., Sorensen, K.J., Thompson, L.H. and Felton, J.S. (1997) Differential effect of acetyltransferase expression on the genotoxicity of heterocyclic amines in CHO cells. Mutat. Res., 390, 93-103.
42. Bounarati, M.H., Turteltaub, K.W., Shen, N.H. and Felton, J.S. (1990) Role of sulfation and acetylation in the activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine to intermediates which bind DNA. Mutat. Res., 245, 185-190.
43. Malfatti, M.A., Buonarati, M.H., Turteltaub, K.W., Shen, N.H. and Felton, J.S. (1994) The role of sulfation and/or acetylation in the metabolism of Salmonella typhimurium and isolated rat hepatocytes. Chem. Res. Toxicol., 7, 139-147.
44. Ozawa, S., Chou, H.C., Kadlubar, F.F., Nagata, K., Yamazoe, Y. and Kato, R. (1994) Activation of 2-hydroxyamino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine by cDNA-expressed human and rat arylsulfotransferases. Jpn. J. Cancer Res., 85, 1220-1228.