메뉴 건너뛰기




Volumn 59, Issue 10, 1998, Pages 737-745

Open-label study of the efficacy, safety, and tolerability of policosanol in patients with high global coronary risk

Author keywords

Cholesterollowering drugs; Dyslipidemia; Policosanol; Type II hypercholesterolemia

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; POLICOSANOL; TRIACYLGLYCEROL;

EID: 0031787854     PISSN: 0011393X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0011-393X(98)85033-9     Document Type: Article
Times cited : (12)

References (40)
  • 1
    • 0021350001 scopus 로고
    • The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in the incidence of coronary heart disease
    • Lipid Research Clinics Program. The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in the incidence of coronary heart disease. JAMA. 1984; 251:351-364.
    • (1984) JAMA , vol.251 , pp. 351-364
  • 2
    • 0021349709 scopus 로고
    • The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in the incidence of coronary heart disease to cholesterol lowering
    • Lipid Research Clinics Program. The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in the incidence of coronary heart disease to cholesterol lowering. JAMA. 1984;251:365-374.
    • (1984) JAMA , vol.251 , pp. 365-374
  • 3
    • 0023232216 scopus 로고
    • Helsinki Heart Study: Primary intervention trial with gemfibrozil in middle-aged men with dislipidemia
    • Frick MH, Elo D, Haapa K, et al. Helsinki Heart Study: Primary intervention trial with gemfibrozil in middle-aged men with dislipidemia. NEJM. 1987;317:1237-1245.
    • (1987) NEJM , vol.317 , pp. 1237-1245
    • Frick, M.H.1    Elo, D.2    Haapa, K.3
  • 4
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol-lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4 S)
    • Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol-lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4 S). Lancet. 1994;344:1383-1389.
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 5
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
    • Sheperd J, Cobbe SM, Christopher G, et al, for the West of Scotland Coronary Prevention Study Group. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. NEJM. 1995;333:1301-1307.
    • (1995) NEJM , vol.333 , pp. 1301-1307
    • Sheperd, J.1    Cobbe, S.M.2    Christopher, G.3
  • 6
    • 0027243348 scopus 로고
    • Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
    • Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). JAMA. 1993;269:3015-3023.
    • (1993) JAMA , vol.269 , pp. 3015-3023
  • 7
  • 8
    • 0026089781 scopus 로고
    • A comparative study of the adverse effects of treatment for hyperlipidemia
    • Steiner A, Weisser B, Vetter W. A comparative study of the adverse effects of treatment for hyperlipidemia. Drug Safety. 1991;6:118-130.
    • (1991) Drug Safety , vol.6 , pp. 118-130
    • Steiner, A.1    Weisser, B.2    Vetter, W.3
  • 9
    • 0028955580 scopus 로고
    • The role of HMG-CoA reductase inhibitors in the treatment of hyperlipidemia: A review of fluvastatin
    • Deslypere JP. The role of HMG-CoA reductase inhibitors in the treatment of hyperlipidemia: A review of fluvastatin. Curr Ther Res. 1995;56:111-128.
    • (1995) Curr Ther Res. , vol.56 , pp. 111-128
    • Deslypere, J.P.1
  • 10
    • 0029092064 scopus 로고
    • Simvastatin: A reappraisal of its pharmacology and therapeutic efficacy in hypercholesterolemia
    • Plosker GL, McTavish D. Simvastatin: A reappraisal of its pharmacology and therapeutic efficacy in hypercholesterolemia. Drugs. 1995;50:334-363.
    • (1995) Drugs , vol.50 , pp. 334-363
    • Plosker, G.L.1    McTavish, D.2
  • 11
    • 0027439338 scopus 로고
    • Effects of successive dose increases of policosanol on the lipid profile and tolerability of treatment
    • Aneiros E, Calderón B, Más R, et al. Effects of successive dose increases of policosanol on the lipid profile and tolerability of treatment. Curr Ther Res. 1993;54:304-315.
    • (1993) Curr Ther Res. , vol.54 , pp. 304-315
    • Aneiros, E.1    Calderón, B.2    Más, R.3
  • 12
    • 0002384735 scopus 로고
    • Estudio comparativo doble ciego de la eficacia y tolerancia del policosanol vs bezafibrato en pacientes con hiperlipidemias tipo II
    • Soltero I, Fuenmayor I, Colmenares J. Estudio comparativo doble ciego de la eficacia y tolerancia del policosanol vs bezafibrato en pacientes con hiperlipidemias tipo II. Arch Venezol Farmacol Terap. 1993;12:71-76.
    • (1993) Arch Venezol Farmacol Terap. , vol.12 , pp. 71-76
    • Soltero, I.1    Fuenmayor, I.2    Colmenares, J.3
  • 13
    • 0028227198 scopus 로고
    • Effects of successive dose increases of policosanol on the lipid profile of patients with type II hypercholesterolemia and tolerability to treatment
    • Pons P, Rodríguez M, Robaina C, et al. Effects of successive dose increases of policosanol on the lipid profile of patients with type II hypercholesterolemia and tolerability to treatment. Int J Clin Pharmacol Res. 1994;14:27-33.
    • (1994) Int J Clin Pharmacol Res. , vol.14 , pp. 27-33
    • Pons, P.1    Rodríguez, M.2    Robaina, C.3
  • 14
    • 0027978416 scopus 로고
    • One year efficacy and safety of policosanol in patients with type II hypercholesterolemia
    • Pons P, Rodríguez M, Más R, et al. One year efficacy and safety of policosanol in patients with type II hypercholesterolemia. Curr Ther Res. 1994;55:1084-1092.
    • (1994) Curr Ther Res. , vol.55 , pp. 1084-1092
    • Pons, P.1    Rodríguez, M.2    Más, R.3
  • 15
    • 0028963194 scopus 로고
    • Effect of policosanol in lowering cholesterol levels in patients with type II hypercholesterolemia
    • Aneiros E, Más R, Calderón B, et al. Effect of policosanol in lowering cholesterol levels in patients with type II hypercholesterolemia. Curr Ther Res. 1995;56:176-182.
    • (1995) Curr Ther Res. , vol.56 , pp. 176-182
    • Aneiros, E.1    Más, R.2    Calderón, B.3
  • 16
    • 0028931289 scopus 로고
    • One-year study of the efficacy and safety of policosanol (5 mg twice daily) in the treatment of type II hypercholesterolemia
    • Castaño G, Más R, Nodarse M, et al. One-year study of the efficacy and safety of policosanol (5 mg twice daily) in the treatment of type II hypercholesterolemia. Curr Ther Res. 1995;56:296-304.
    • (1995) Curr Ther Res. , vol.56 , pp. 296-304
    • Castaño, G.1    Más, R.2    Nodarse, M.3
  • 17
    • 0029589212 scopus 로고
    • A two year study on the efficacy and tolerability of policosanol in patients with type II hyperlipoproteinemia
    • Canetti M, Moreira M, Illnait J, et al. A two year study on the efficacy and tolerability of policosanol in patients with type II hyperlipoproteinemia. Int J Clin Pharmacol Res. 1995;15:159-165.
    • (1995) Int J Clin Pharmacol Res. , vol.15 , pp. 159-165
    • Canetti, M.1    Moreira, M.2    Illnait, J.3
  • 18
    • 0029155739 scopus 로고
    • Efficacy and tolerability of policosanol in elderly patients with type II hyperlipoproteinemia: A 12-month study
    • Castaño G, Canetti M, Moreira M, et al. Efficacy and tolerability of policosanol in elderly patients with type II hyperlipoproteinemia: A 12-month study. Curr Ther Res. 1995;56: 819-828.
    • (1995) Curr Ther Res. , vol.56 , pp. 819-828
    • Castaño, G.1    Canetti, M.2    Moreira, M.3
  • 19
    • 0028897637 scopus 로고
    • Treatment of hypercholesterolemia in NIDDM with policosanol
    • Torres O, Agramonte AJ, Illnait J, et al. Treatment of hypercholesterolemia in NIDDM with policosanol. Diabetes Care. 1995;18:393-397.
    • (1995) Diabetes Care , vol.18 , pp. 393-397
    • Torres, O.1    Agramonte, A.J.2    Illnait, J.3
  • 20
    • 0029945522 scopus 로고    scopus 로고
    • Effects of policosanol on hypercholesterolemic patients with abnormal serum biochemical indicators of hepatic function
    • Zardoya R, Tula L, Castaño G, et al. Effects of policosanol on hypercholesterolemic patients with abnormal serum biochemical indicators of hepatic function. Curr Ther Res. 1996;57:568-577.
    • (1996) Curr Ther Res. , vol.57 , pp. 568-577
    • Zardoya, R.1    Tula, L.2    Castaño, G.3
  • 21
    • 0002973009 scopus 로고    scopus 로고
    • Estudio dosis-efecto de la acción hipocolesterolémica del policosanol en pacientes con hiperlipoproteinemia tipo II
    • Castaño G, Illnait J, Fernández L, et al. Estudio dosis-efecto de la acción hipocolesterolémica del policosanol en pacientes con hiperlipoproteinemia tipo II. Rev CENIC Cien Biol. 1996;27:38-40.
    • (1996) Rev CENIC Cien Biol. , vol.27 , pp. 38-40
    • Castaño, G.1    Illnait, J.2    Fernández, L.3
  • 22
    • 0029829726 scopus 로고    scopus 로고
    • Effects of policosanol in hypertensive patients with type II hypercholesterolemia
    • Castaño G, Tula L, Canetti M, et al. Effects of policosanol in hypertensive patients with type II hypercholesterolemia. Curr Ther Res. 1996;57:691-699.
    • (1996) Curr Ther Res. , vol.57 , pp. 691-699
    • Castaño, G.1    Tula, L.2    Canetti, M.3
  • 23
    • 0343071027 scopus 로고    scopus 로고
    • Comparación de los efectos del policosanol y la lovastatina en pacientes con hipercolesterolemia primaria tipo II
    • Castaño G, Nodarse M, Más R, et al. Comparación de los efectos del policosanol y la lovastatina en pacientes con hipercolesterolemia primaria tipo II. Rev CENIC Cien Biol. 1996;27:57-63.
    • (1996) Rev CENIC Cien Biol. , vol.27 , pp. 57-63
    • Castaño, G.1    Nodarse, M.2    Más, R.3
  • 24
    • 0030889985 scopus 로고    scopus 로고
    • Comparative effects of two once-daily regimens of policosanol in patients with type II hypercholesterolemia
    • Castaño G, Más R, Fernández JC, Illnait J. Comparative effects of two once-daily regimens of policosanol in patients with type II hypercholesterolemia. Curr Ther Res. 1997; 58:154-162.
    • (1997) Curr Ther Res. , vol.58 , pp. 154-162
    • Castaño, G.1    Más, R.2    Fernández, J.C.3    Illnait, J.4
  • 25
    • 0001452846 scopus 로고    scopus 로고
    • Eficacia, seguridad y tolerabilidad del policosanol en pacientes argentinos con hipercolesterolemia tipo II. Estudio abierto
    • Campilongo R, Sandini P, Feldman R, et al. Eficacia, seguridad y tolerabilidad del policosanol en pacientes argentinos con hipercolesterolemia tipo II. Estudio abierto. Prensa Méd Argent. 1996;83:665-672.
    • (1996) Prensa Méd Argent , vol.83 , pp. 665-672
    • Campilongo, R.1    Sandini, P.2    Feldman, R.3
  • 26
    • 0031019054 scopus 로고    scopus 로고
    • A comparative study of policosanol versus probucol in patients with hypercholesterolemia
    • Pons P, Illnait J, Más R, et al. A comparative study of policosanol versus probucol in patients with hypercholesterolemia. Curr Ther Res. 1997;58:26-35.
    • (1997) Curr Ther Res. , vol.58 , pp. 26-35
    • Pons, P.1    Illnait, J.2    Más, R.3
  • 27
    • 0031018756 scopus 로고    scopus 로고
    • Effect of policosanol on patients with non-insulin-dependent diabetes mellitus (NIDDM) and hypercholesterolemia
    • Crespo N, Alvarez R, Más R, et al. Effect of policosanol on patients with non-insulin-dependent diabetes mellitus (NIDDM) and hypercholesterolemia. Curr Ther Res. 1997; 58:44-51.
    • (1997) Curr Ther Res. , vol.58 , pp. 44-51
    • Crespo, N.1    Alvarez, R.2    Más, R.3
  • 28
    • 0030857721 scopus 로고    scopus 로고
    • A comparative study of policosanol versus simvastatin in elderly patients with hypercholesterolemia
    • Ortensi G, Gladstein H, Valli H, Tesone PA. A comparative study of policosanol versus simvastatin in elderly patients with hypercholesterolemia. Curr Ther Res. 1997;58:390-401.
    • (1997) Curr Ther Res. , vol.58 , pp. 390-401
    • Ortensi, G.1    Gladstein, H.2    Valli, H.3    Tesone, P.A.4
  • 29
    • 0001353911 scopus 로고
    • Acute, subchronic and chronic toxicity of policosanol in rats
    • Rome, June 28-July 3. Abstract
    • Alemán CL, Rodeiro I, Noa M, et al. Acute, subchronic and chronic toxicity of policosanol in rats. Presented at the Sixth International Congress of Toxicology, Rome, June 28-July 3. 1992:248. Abstract.
    • (1992) Sixth International Congress of Toxicology , vol.248
    • Alemán, C.L.1    Rodeiro, I.2    Noa, M.3
  • 30
    • 0027957267 scopus 로고
    • A 12 month study of policosanol oral toxicity in Sprague-Dawley rats
    • Alemán CL, Más R, Hernández C, et al. A 12 month study of policosanol oral toxicity in Sprague-Dawley rats. Toxicol Lett. 1994;70:77-87.
    • (1994) Toxicol Lett. , vol.70 , pp. 77-87
    • Alemán, C.L.1    Más, R.2    Hernández, C.3
  • 31
    • 0028033806 scopus 로고
    • Carcinogenicity of policosanol in Sprague Dawley rats: A 24 month study
    • Alemán CL, Más R, Noa M, et al. Carcinogenicity of policosanol in Sprague Dawley rats: A 24 month study. Teratog Carcinog Mutag. 1994;14:239-249.
    • (1994) Teratog Carcinog Mutag. , vol.14 , pp. 239-249
    • Alemán, C.L.1    Más, R.2    Noa, M.3
  • 32
    • 0028144949 scopus 로고
    • Toxicity of policosanol in Beagle dogs: One year study
    • Mesa AR, Más R, Noa M, et al. Toxicity of policosanol in Beagle dogs: One year study. Toxicol Lett. 1994;73:81-90.
    • (1994) Toxicol Lett. , vol.73 , pp. 81-90
    • Mesa, A.R.1    Más, R.2    Noa, M.3
  • 33
    • 0028122593 scopus 로고
    • Effect of policosanol chronically administered in male monkeys (Macaca arctoides)
    • Rodríguez C, Mesa R, Más R, et al. Effect of policosanol chronically administered in male monkeys (Macaca arctoides). Food Chem Toxicol. 1994;32:565-575.
    • (1994) Food Chem Toxicol. , vol.32 , pp. 565-575
    • Rodríguez, C.1    Mesa, R.2    Más, R.3
  • 34
    • 0028174497 scopus 로고
    • Teratogenic and reproductive studies of policosanol in the rat and rabbit
    • Rodríguez MD, García H. Teratogenic and reproductive studies of policosanol in the rat and rabbit. Teratog Carcinog Mutag. 1994;14:107-113.
    • (1994) Teratog Carcinog Mutag. , vol.14 , pp. 107-113
    • Rodríguez, M.D.1    García, H.2
  • 35
    • 0029164702 scopus 로고
    • Carcinogenicity of policosanol in mice: An 18 month study
    • Alemán C, Noa M, Cerejido E, et al. Carcinogenicity of policosanol in mice: An 18 month study. Food Chem Toxicol. 1995;33:573-578.
    • (1995) Food Chem Toxicol. , vol.33 , pp. 573-578
    • Alemán, C.1    Noa, M.2    Cerejido, E.3
  • 36
    • 0030043107 scopus 로고    scopus 로고
    • Drug therapy for hypercholesterolemia in patients with cardiovascular disease: Factor limiting achievement of lipid goals
    • Schectman G, Hiatt J. Drug therapy for hypercholesterolemia in patients with cardiovascular disease: Factor limiting achievement of lipid goals. Am J Med. 1996;100:197-204.
    • (1996) Am J Med. , vol.100 , pp. 197-204
    • Schectman, G.1    Hiatt, J.2
  • 37
    • 0024513867 scopus 로고
    • Diabetes mellitus and hypertension in the elderly: Concomitant hyperlipidemia and coronary heart disease risk
    • Assmann G, Schulte H. Diabetes mellitus and hypertension in the elderly: Concomitant hyperlipidemia and coronary heart disease risk. Am J Cardiol. 1989;63(Suppl H):33-37.
    • (1989) Am J Cardiol. , vol.63 , Issue.SUPPL. H , pp. 33-37
    • Assmann, G.1    Schulte, H.2
  • 38
    • 0019488877 scopus 로고
    • Separation of serum high-density lipoprotein for cholesterol determination: Ultracentrifugation vs precipitation with sodium phosphotungstate and magnesium chloride
    • Seigler L, Wu WT. Separation of serum high-density lipoprotein for cholesterol determination: Ultracentrifugation vs precipitation with sodium phosphotungstate and magnesium chloride. Clin Chem. 1981;27:838-841.
    • (1981) Clin Chem. , vol.27 , pp. 838-841
    • Seigler, L.1    Wu, W.T.2
  • 39
    • 0015348189 scopus 로고
    • Estimation of the concentration of low-density-lipoprotein cholesterol in plasma without the use of preparative ultracentrifuge
    • Friedewald WT, Levy RI, Friederickson SD. Estimation of the concentration of low-density-lipoprotein cholesterol in plasma without the use of preparative ultracentrifuge. Clin Chem. 1972;18:499-502.
    • (1972) Clin Chem. , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Friederickson, S.D.3
  • 40
    • 0024150417 scopus 로고
    • An overview of lipid-lowering
    • Illingworth DR. An overview of lipid-lowering. Drugs. 1988;86(Suppl 3):63-71.
    • (1988) Drugs , vol.86 , Issue.3 SUPPL. , pp. 63-71
    • Illingworth, D.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.