Prolonged elevation in blood pressure in the unrestrained rat exposed to chlorpyrifos

Toxicology

Volumn 146, Issue 1, 2000, Pages 1-13

  Gordon, Christopher J ^a   Padnos, Beth K ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Anticholinesterase; Blood pressure; Body temperature; Heart rate; Motor activity; Organophosphate pesticide; Pulse pressure

Indexed keywords

CHLORPYRIFOS; CHOLINESTERASE INHIBITOR; ORGANOPHOSPHATE PESTICIDE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE MONITORING; BLOOD PRESSURE REGULATION; CENTRAL NERVOUS SYSTEM; CHOLINERGIC STIMULATION; CONTROLLED STUDY; CORE TEMPERATURE; DIASTOLIC BLOOD PRESSURE; DOSE RESPONSE; HEART RATE; HYPERTENSION; MALE; MEAN ARTERIAL PRESSURE; MOTOR ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PULSE PRESSURE; RAT; SYSTOLIC BLOOD PRESSURE; TELEMETRY; VASCULAR RESISTANCE;

ADMINISTRATION, ORAL; ANIMALS; BLOOD PRESSURE; BODY TEMPERATURE; CHLORPYRIFOS; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; HEART RATE; INSECTICIDES; MALE; MOTOR ACTIVITY; RATS; RATS, LONG-EVANS; TELEMETRY;

CHANDIPURA VIRUS;

EID: 0034690205     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(00)00158-X     Document Type: Article

References (28)

1. Aspelin, A. 1994. Pesticides industry sales and usage-1992 and 1993 market estimates. U.S. Environmental Protection Agency, report no. 733-K-94-001, June.
2. Ballantyne B., Marrs T.C. Overview of the biological and clinical aspects of organophosphates and carbamates. Ballantyne B., Marrs T.C. Clinical and Experimental Toxicology of Organophosphates and Carbamates. 1992;3-14 Butterworth-Heinemann, Oxford.
3. Bataillard A., Sannajust F., Yoccoz D., Blanchet G., Sentenac-Roumanou H., Sassard J. Cardiovascular consequences of organophosphorus poisoning and of antidotes in conscious unrestrained rats. Pharmacol. Toxicol. 67:1990;27-35.
4. Brezenoff H.E., McGee J., Knight V. The hypertensive response to soman and its relation to brain acetylcholinesterase inhibition. Acta Pharmacol. Toxicol. 55:1984;270-277.
5. Buccafusco J.J. The role of central cholinergic neurons in the regulation of blood pressure and in experimental hypertension. Pharmacol. Rev. 48:1996;179-211.
6. Gordon C.J., Fogelson L., Lee L., Highfill J. Acute effects of diisopropyl fluorophosphate (DFP) on autonomic and behavioral thermoregulatory responses in the Long-Evans rat. Toxicology. 67:1991;1-14.
7. Gordon C.J. Thermoregulation in laboratory mammals and humans exposed to anticholinesterase agents. Neurotoxicol. Terat. 16:1994;427-453.
8. Gordon C.J., Rowsey P.J. Poisons and fever. Clin. Exp. Pharm. Physiol. 25:1998;145-149.
9. Gordon, C.J., Y.-L. Yang. 2000. Chlorpyrifos-induced hypothermia and vasodilation in the tail of the rat: blockade by scopolamine. Pharmacol. Toxicol. (in press).
10. Guyton A.C. Textbook of Medical Physiology. seventh edition:1986;W.B. Saunders, Philadelphia.
11. Janowsky D.S., Rish S.C., Kennedy B., Ziegler M., Huey L. Central muscarinic effects of physostigmine on mood, cardiovascular function, pituitary and adrenal neuroendocrine release. Psychopharmacol. 89:1986;150-154.
12. Kennedy B., Janowsky D.S., Risch S.C., Ziegler M.G. Central cholinergic stimulation causes adrenal epinephrine release. J. Clin. Invest. 74:1984;972-975.
13. Kim S.Y., Raikoff K., Wulfert E., Hanin I. Bradycardia induced by mivazerol, a selective alpha 2-adrenoceptor agonist, is amplified during mild hypothermia in the pentobarbital-anesthetized rat. Cardiovasc. Drugs Ther. 11:1997;751-755.
14. Kojima T., Tsuda S., Shirasu Y. Non-cholinergic mechanisms underlying the acute lethal effects of P=S type organophosphorus insecticides in rats. J. Vet. Med. Sci. 54:1992;529-533.
15. Lazartigues E, Freslon J.L., Tellioglu T., Brefel-Courbon C., Pelat M., Tran M.A., Montastruc J.L., Rascol O. Pressor and bradycardic effects of tacrine and other acetylcholinesterase inhibitors in the rat. Eur. J. Pharmacol. 361:1998;61-71.
16. Lazartigues E., Brefel-Courbon C., Tran M.A., Montastruc J.L., Rascol O. Spontaneously hypertensive rats cholinergic hyper-responsiveness: central and peripheral pharmacological mechanisms. Br. J. Pharmacol. 127:1999;1657-1665.
17. Lebrun C., Rohmeiss P., Demmert G., Unger T. Central cardiovascular actions of vasopressin in the rat. Can. J. Physiol. Pharmacol. 65:1987;1712-1716.
18. Moser V.C., Padilla S. Age- and gender-related differences in the time-course of behavioral and biochemical effects produced by oral chlorpyrifos in rats. Toxicol. Appl. Pharmacol. 149:1998;107-119.
19. Meeter E. The effect of atropine on the hypothermia and the shift in set-point for heat release evoked by a cholinesterase inhibitor in the rat. Proc. Royal Neth. Acad. Sci. Series C. 74:1971;105-112.
20. Nostrandt A.C., Padilla S., Moser V.C. The relationship of oral chlorpyrifos effects on behavior, cholinesterase inhibition, and muscarinic receptor density in rat. Pharm. Biochem. Behav. 58:1997;15-23.
21. Philippu A. Involvement of cholinergic system of the brain in the central regulation of cardiovascular functions. J. Auton. Pharmac. 1:1981;321-330.
22. Preston E., Heath C. Atropine-insensitive vasodilation and hypotension in the organophosphate-poisoned rabbit. Arch. Int. Pharmacodyn. 200:1972;231-244.
23. Saad W.A., Luiz A.C., Camargo L.A., Silveira J.E., Foglia S., Menani J.V., Saad W.A. Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol. Braz. J. Med. Biol. Res. 30:1997;493-496.
24. Saadeh A.M., Al-Ali M.K., Farsakh N.A., Ghani M. Clinical and sociodemographic features of acute carbamate and organophosphate poisoning: a study of 70 adult patients in North Jordan. Clin. Toxicol. 34:1996;45-51.
25. Saadeh A.M., Farsakh N.A., al-Ali M.K. Cardiac manifestations of acute carbamate and organophosphate poisoning. Heart. 77:1997;461-464.
26. Tafuri J., Roberts J. Organophosphate poisoning. Ann. Emerg. Med. 16:1987;193-202.
27. Varagic V.M., Prostran M.S., Stepanovic S., Savic J., Vujnov S. Transmitter interactions in the central cholinergic control of blood pressure regulation. Drug Metab. Interact. 9:1991;49-76.
28. Vidrio H., Garcia-Marquez F. Reversal by hypothermia of vasodilator-induced tachycardia in anesthetized rats. Arch. Int. Pharmacodyn. Ther. 288:1987;217-228.