Chlorpyrifos-induced hypothermia and vasodilation in the tail of the rat: Blockade by scopolamine

Pharmacology and Toxicology

Volumn 87, Issue 1, 2000, Pages 6-10

  Gordon, Christopher J ^a,b   Yang, Yong Lu ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORPYRIFOS; SCOPOLAMINE;

ANIMAL EXPERIMENT; ARTICLE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; CORE TEMPERATURE; FEMALE; HYPOTHERMIA; MOTOR ACTIVITY; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN TEMPERATURE; THERMOREGULATION; VASODILATATION;

ANIMALIA; RODENTIA;

EID: 0033891446     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0901-9928.2000.870102.x     Document Type: Article

References (17)

1. Aspelin, A.: Pesticides industry sales and usage-1992 and 1993 market estimates. U.S. Environmental Protection Agency, report no. 733-K-94-001, June, 1994.
2. Ballantyne, B. & T. C. Marrs: Overview of the biological and clinical aspects of organophosphates and carbamates. In: Clinical and experimental toxicology of organophosphates and carbamates. Eds.: B. Ballantyne & T. C. Marrs. Butterworth-Heinemann, Oxford 1992, pp. 3-14.
3. Bauer, R. H.: Age-dependent effects of scopolamine on avoidance, locomotor activity, and rearing. Behav. Brain Res. 1982, 5, 261-279.
4. Dawson, N. J. & A. W. Keber: Physiology of heat loss from an extremity: The tail of the rat. Clin. Exp. Pharmacol. Physiol. 1979, 6, 69-80.
5. Gordon, C. J., L. Fogelson, L. Lee, & J. Highfill: Acute effects of diisopropyl fluorophosphate (DFP) on autonomic and behavioral thermoregulatory responses in the Long-Evans rat. Toxicology 1991, 67, 1-14.
6. Gordon, C. J.: Temperature regulation in laboratory rodents. Cambridge University Press, New York 1993.
7. Gordon, C. J. & L. Fogelson: Relationship between serum cholinesterase activity and the change in body temperature and motor activity in the rat: a dose-response study of diisopropyl fluorophosphate. Neurotoxicol. Terat. 1993, 15, 21-25.
8. Gordon, C. J.: Thermoregulation in laboratory mammals and humans exposed to anticholinesterase agents. Neurotoxicol. Terat. 1994, 16, 427-453.
9. Gordon, C. J., T. Grantham & Y. Yang: Hypothermia and delayed fever in the male and female rat exposed to chlorpyrifos. Toxicology 1997, 118, 149-158.
10. Gordon, C. J.: Behavioral thermoregulatory response to chlorpyrifos in the rat. Toxicology 1997, 124, 165-171.
11. Gordon, C. J. & T. Grantham: Effects of central and peripheral cholinergic antagonists on chlorpyrifos-induced changes in body temperature in the rat. Toxicology 2000, 142, 15-28.
12. Meeter, E.: The effect of atropine on the hypothermia and the shift in set-point for heat release evoked by a cholinesterase inhibitor in the rat. Proc. Roy. Neth. Acad. Sci. Series C 1971, 74, 105-112.
13. Moser, V. C. & S. Padilla: Age- and gender-related differences in the time course of behavioral and biochemical effects produced by oral chlorpyrifos in rats. Toxicol. Appl. Pharmacol. 1998, 149, 107-119.
14. Romanovsky, A. A. & C. M. Blatteis: Heat stroke: opioid-mediated mechanisms. J. Appl. Physiol. 1996, 81, 2565-2570.
15. Pope, C. N, Chakraborti, T. K., Chapman, M. L. & J. D. Farrar: Long-term neurochemical and behavioral effects induced by acute chlorpyrifos treatment. Pharmacol. Biochem. Behav. 1992, 42, 251-256.
16. Tonta, M. A., H. C. Parkington, M. Tare & H. A. Coleman: Pilocarpine-induced relaxation of rat tail artery by a non-cholinergic mechanism and in the absence of an intact endothelium. Brit. J. Pharmacol. 1994, 112, 525-532.
17. Young, A. A. & N. J. Dawson: Evidence for on-off control of heat dissipation from the tail of the rat. Can. J. Physiol. Pharmacol. 1982, 60, 392-398.