Library synthesis using solution phase capping of solid phase derived intermediates

Tetrahedron Letters

Volumn 41, Issue 12, 2000, Pages 2023-2026

  Teague, Simon J ^a   Walters, Iain A S ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Combinatorial chemistry; Solid phase synthesis

Indexed keywords

AMINE; BENZYL DERIVATIVE; ETHER DERIVATIVE; SULFIDE;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; SYNTHESIS;

EID: 0034681857     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)00094-0     Document Type: Article

References (16)

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9. ™ 2 ml fritted boxes from Porvair Sciences UK.
10. TMSBr cleavage procedure: A 20% solution of TMSBr in 1,2-dichloroethane (2 ml) was filtered through 100 mg of resin contained in each well of a Porvair reaction box and the filtrate collected in a standard 2 ml 96-well plate directly underneath. The collection box was heat sealed with a polyethylene film and left to stand at room temperature for seven days. The TMSBr solution was removed by evaporation in a vacuum dessicator after punching holes in the polyethylene film. The benzyl bromide intermediates were dried under vacuum for three days before being dissolved in DMSO prior to solution phase capping.
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12. We used Tomtec Quadra 96 robots.
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