Synthesis and enzymatic evaluation of a P1 arginine aminocoumarin substrate library for trypsin-like serine proteases

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 20, 2000, Pages 2291-2294

  Edwards, Philip D ^a   Mauger, Russell C ^a   Cottrell, Kevin M ^a   Morris, Frank X ^a   Pine, Kara K ^a   Sylvester, Mark A ^a   Scott, Clay W ^a   Furlong, Stephen T ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE DERIVATIVE; SERINE PROTEINASE; TETRAPEPTIDE; TRYPTASE;

AMINO ACID SEQUENCE; ARTICLE; DRUG SYNTHESIS; ENZYME SUBSTRATE COMPLEX; PEPTIDE SYNTHESIS;

ARGININE; COUMARINS; HUMAN; OLIGOPEPTIDES; PEPTIDE LIBRARY; PROTEIN CONFORMATION; SERINE ENDOPEPTIDASES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THROMBIN; TRYPSIN;

EID: 0034675803     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00460-1     Document Type: Article

References (13)