A novel Na+ and Ca2+ channel blocker, T-477, prevents brain edema following microsphere-induced permanent occlusion of cerebral arterioles in rats

Japanese Journal of Pharmacology

Volumn 81, Issue 2, 1999, Pages 170-175

  Okuyama, Kayoko ^a   Kiuchi, Satoko ^a   Okamoto, Masahito ^a   Narita, Hiroshi ^a   Kudo, Yukitsuka ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Brain edema; Ischemia; Microsphere; T 477; Unanesthetized rat

Indexed keywords

2 (4 CHLOROPHENYL) 4 DIETHYLAMINOACETYL 2,3 DIHYDRO 4H 1,4 BENZOTHIAZINE; CALCIUM CHANNEL BLOCKING AGENT; MICROSPHERE; POTASSIUM; SODIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG; ELECTROLYTE; GLYCEROL; THIAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIOLE; ARTICLE; BLOOD VESSEL OCCLUSION; BRAIN EDEMA; BRAIN WATER; CONTROLLED STUDY; DOSE RESPONSE; DRUG STRUCTURE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; RAT; ANIMAL; BODY TEMPERATURE; BODY WATER; BODY WEIGHT; BRAIN EMBOLISM; BRAIN LEVEL; DRUG EFFECT; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ARTERIOLES; BODY TEMPERATURE; BODY WATER; BODY WEIGHT; BRAIN CHEMISTRY; BRAIN EDEMA; CALCIUM CHANNEL BLOCKERS; ELECTROLYTES; GLYCEROL; INTRACRANIAL EMBOLISM; MALE; MICROSPHERES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNEL BLOCKERS; THIAZINES;

EID: 0032586016     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.81.170     Document Type: Article

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