Ca2+-channel blockers and nucleoside triphosphate diphosphohydrolase (NTPDase) influence of diltiazem, nifedipine, and verapamil

Biochemical Pharmacology

Volumn 60, Issue 12, 2000, Pages 1959-1965

  Gendron, Fernand Pierre ^a   Latour, Jean Gilles ^b   Gravel, Denis ^b   Wang, Yuan ^b   Beaudoin, Adrien R ^a  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Apyrase; Ca2+ antagonists; Ectonucleotidases; Enzyme inhibition; NTPDase; Purine metabolism

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; APYRASE; CALCIUM CHANNEL BLOCKING AGENT; DEACETYL N NORDILTIAZEM; DEACETYL N,O DINORDILTIAZEM; DEACETYL O NORDILTIAZEM; DILTIAZEM; DRUG METABOLITE; ENZYME INHIBITOR; N NORDILTIAZEM; NIFEDIPINE; VERAPAMIL;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL TONE; CATTLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; HYPERTENSION; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PURINE METABOLISM; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

ANIMALS; BINDING, COMPETITIVE; CALCIUM CHANNEL BLOCKERS; CATTLE; DILTIAZEM; KINETICS; NIFEDIPINE; PYROPHOSPHATASES; VERAPAMIL;

EID: 0034672527     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00511-6     Document Type: Article

References (33)

1. Hypertension and the coronary circulation. With special attention to endothelial regulation
2. The control of nucleotides in blood vessels: Role of the ATP diphosphohydrolase (apyrase)
3. Physiological role of NTPDases (ATP diphosphohydrolases) in mammals
4. Nucleotides and cd39: Principal modulatory players in hemostasis and thrombosis
5. Characterization of ATP-diphosphohydrolase activities in the intima and media of bovine aorta: Evidence for a regulatory role in platelet activation in vitro
6. Purification of the blood vessel ATP diphosphohydrolase, identification and localisation by immunological techniques
7. A nucleotide receptor in vascular endothelial cells is specifically activated by the fully ionized forms of ATP and UTP
8. The cloning and expression of G protein coupled P2Y nucleotide receptors
9. Effects of ATP and related nucleotides on the tone of isolated rat mesenteric resistance arteries
10. Involvement of multiple receptors in the actions of extracellular ATP: The example of vascular endothelial cells
11. Cardiovascular pharmacology of purines
12. Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides
13. ATP diphosphohydrolases, apyrases and nucleotide phosphohydrolases: Biochemical properties and functions
14. Characterization and purification of a calcium-sensitive ATP diphosphohydrolase from the pig pancreas
15. Purification and properties of human placental ATP diphosphohydrolase
16. Purification and identification by immunological techniques of different isoforms of mammalian ATP diphosphohydrolase
17. The CD39 lymphoid cell activation antigen: Molecular cloning and structural characterization
18. Identification and characterization of CD39/vascular ATP diphosphohydrolase
19. 2+)-apyrase
20. Antithrombic activity of glomerular adenosine diphosphatase in the glomerular basement membrane of the rat kidney
21. Expression, distribution, and biochemistry of human CD39. Role in activation-associated homotypic adhesion of lymphocytes
22. Demonstration of antithrombic activity of glomerular adenosine diphosphatase
23. 2+ antagonistic activity of diltiazem metabolites
24. Identification, characterization, and immunolocalization of a nucleoside triphosphate diphosphohydrolase in pig liver
25. A malachite green procedure for orthophosphate determination and its use in alkaline phosphatase-based enzyme immunoassay
26. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding
27. N-monodesmethyldiltiazem is the predominant metabolite of diltiazem in the plasma of young and elderly hypertensives
28. Cardiovascular effects of the metabolites of diltiazem in dogs
29. Novel nucleoside triphosphate diphosphohydrolase inhibitors: Chemical synthesis, biochemical and pharmacological characterization
30. The transmembrane domains of ectoapyrase (CD39) affect its enzymatic activity and quaternary structure
31. Control of cell membrane ecto-ATPase by oligomerization state: Intermolecular cross-linking modulates ATPase activity
32. Identification of binding sites for calcium channel antagonists
33. Steady-state plasma concentrations of diltiazem and its metabolites in patients and healthy volunteers