Identification of binding sites for calcium channel antagonists

Japanese Heart Journal

Volumn 37, Issue 5, 1996, Pages 643-650

  Nakayama, Hitoshi ^a   Kuniyasu, Akihiko ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

1,4 dihydropyridine; Anti peptide antibody; Benzothiazepines; L type calcium channels; Phenylalkylamines; Photoaffinity labeling; Primary structure

Indexed keywords

BENZOTHIAZEPINE DERIVATIVE; CALCIUM ANTAGONIST; CALCIUM CHANNEL; DIHYDROPYRIDINE DERIVATIVE; PHENYLALKYLAMINE;

ANGINA PECTORIS; CONFERENCE PAPER; DRUG BINDING SITE; DRUG STRUCTURE; HYPERTENSION; PHOTOAFFINITY LABELING; PRIORITY JOURNAL;

EID: 0029914104     PISSN: 00214868     EISSN: None     Source Type: Journal    
DOI: 10.1536/ihj.37.643     Document Type: Conference Paper

References (23)

1. Catterall WA. Strucuture and function of voltage-sensitive ion channels. Science 1988; 242. 50-61.
2. Tanabe T, Beam KG, Powell JA, Numa S. Restoration of excitation-contraction coupling and slow calcium current in dysgenic muscle by dihydropyridine receptor complementary DNA. Nature 1988; 336: 134-9.
3. Vaghy PL, Williams JS, Schwartz A. Receptor pharmacology of calcium entry blocking agents. Am J Cardiol 1987; 59: 9A-17A
4. Janis RA, Silver PJ, Triggle DI Drug action and cellular calcium regulation. Adv Drug Res 1987; 16: 309-591.
5. Glossmann H, Striessnig J. Calcium channels. Vitamins and Hormones 1988; 44: 155-328.
6. Noda M, Shimizu S, Tanabe T, et al. Primary structure of the electrophorus electricus sodium channel deduced by cDNA cloning. Nature 1984; 312: 121-7.
7. Kass RS, Arena JP. Influence of pH(o) on calcium channel block by amlodipine, a charged dihydropyridine compound. Implications for location of the dihydropyridine receptor. J Gen Physiol 1989; 93: 1109-27.
8. Kass RS, Arena JP, Chin S Block of L-type calcium channels by charged dihydropyridines. Sensitivity to side of application and calcium. J Gen Physiol 1991; 98: 63-75.
9. Nakayama H, Taki M, Striessnig J, Glossmann H, Caterall WA, Kanaoka Y. Identification of 1,4-dihydropyridine binding regions within the alpha1 subunit of the skeletal muscle calcium channel by photoaffinity labeling with diazipine. Proc Natl Acad Sci USA 1991; 88: 9203-7.
10. Taki M, Nakayama H, Kanaoka Y Diazipine, a novel photoaffinity probe for dihydropyridine receptors of calcium channels. FEBS Lett 1991; 283: 259-62.
11. 3H] diazipine: Novel dihydropyridine probes of calcium channels. Chem Pharm Bull 1991; 39: 1860-2.
12. Nakayama H, Taki M, Kanaoka Y. Synthesis and properties of diazipine, a novel photoaffinity probe for calcium channel-linked dihydropyridine receptors. In: Glossmann H, Striessnig J, editors. Methods in Pharmacology; vol. 7, New York: Plenum Press Inc, 1993: 255-66.
13. Jones M Jr, Moss RA, Carbenes , vol. 1, Wiley Inc, New York, 1973; idems, Carbenes, vol. 2, Wiley Inc, New York, 1975.
14. Jones M Jr, Moss RA, Carbenes , vol. 1, Wiley Inc, New York, 1973; idems, Carbenes, vol. 2, Wiley Inc, New York, 1975.
15. 2+ channels. Proc Natl Acad Sci USA 1991; 88: 10769-73.
16. 1 subunit. EMBO J 1991; 10: 45-9.
17. 2+ channels. Proc Natl Acad Sci USA 1990; 87: 9108-12.
18. Hescheler J, Pelzer D, Trube G, Trautwein W. Does the organic calcium channel blocker D600 act from inside or outside on the cardiac cell membranes? Pfluegers Arch 1982; 393: 287-91.
19. 1 subunit of the skeletal muscle calcium channel. FEBS Lett 1993; 344: 261-4.
20. 3H] azidobutyryl diltiazem. J Biol Chem 1989; 264: 21211-4.
21. Adachi-Akahane S, Amano Y, Okuyama R, Nagao T. Quarternary diltiazem can act from both sides of the membrane in ventricular myocytes. Japan J Pharmacol 1993; 61: 263-6.
22. 2+ channels. Mol Pharmacol 1993; 43: 820-6.
23. 3H] azidobutyryl clentiazem. Master Dissertation (Kumamoto University) 1996