Structure-specific control of differentiation and apoptosis of human promyelocytic leukemia (HL-60) cells by A-ring diastereomers of 2-methyl-1α,25-dihydroxyvitamin D3 and its 20-epimer

Biochemical Pharmacology

Volumn 60, Issue 12, 2000, Pages 1937-1947

  Nakagawa, Kimie ^a   Kurobe, Mayuko ^a   Konno, Katsuhiro ^b   Fujishima, Toshie ^b   Takayama, Hiroaki ^b   Okano, Toshio ^a  

^a KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

^b TEIKYO UNIVERSITY   (Japan)

Author keywords

2 Methyl 1 ,25(OH)2D3; 2 Methyl 20 epi 1 ,25(OH)2D3; A ring stereoisomers; Apoptosis; Differentiation; Growth inhibition; HL 60 cells; St ructural motif

Indexed keywords

2 METHYL 20 EPICALCITRIOL; 2 METHYLCALCITRIOL; ANTILEUKEMIC AGENT; CALCITRIOL; CALCITRIOL DERIVATIVE; CASPASE 3; CD11B ANTIGEN; DNA FRAGMENT; MEMBRANE ANTIGEN; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL NUCLEUS; CELL STRAIN HL 60; CONTROLLED STUDY; DIASTEREOISOMER; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NICK END LABELING; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; CELL CYCLE; CELL DIFFERENTIATION; DNA FRAGMENTATION; ELECTROPHORESIS, AGAR GEL; HL-60 CELLS; HUMANS; IN SITU NICK-END LABELING; LEUKEMIA, PROMYELOCYTIC, ACUTE; MACROPHAGE-1 ANTIGEN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VITAMIN D;

EID: 0034672526     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00486-X     Document Type: Article

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