Effect of trichostatin A on cell growth and expression of cell cycle- and apoptosis-related molecules in human gastric and oral carcinoma cell lines

International Journal of Cancer

Volumn 88, Issue 6, 2000, Pages 992-997

  Suzuki, Tetsuo ^a,b   Yokozaki, Hiroshi ^a   Kuniyasu, Hiroki ^a   Hayashi, Ken ^a   Naka, Kazuhito ^a   Ono, Shigehiro ^a,b   Ishikawa, Takenori ^b   Tahara, Eiichi ^a   Yasui, Wataru ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALITRETINOIN; BETA INTERFERON; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIN A; CYCLIN E; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEIN BAK; PROTEIN BAX; PROTEIN P21; TRICHOSTATIN A;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL CYCLE; CELL GROWTH; CONTROLLED STUDY; CYTOPLASM; HUMAN; HUMAN CELL; MOUTH CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STOMACH CARCINOMA;

APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CELL CYCLE PROTEINS; CELL DIVISION; DNA FRAGMENTATION; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; HYDROXAMIC ACIDS; MEMBRANE PROTEINS; MOUTH NEOPLASMS; POLY(ADP-RIBOSE) POLYMERASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; STOMACH NEOPLASMS; TIME FACTORS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034672294     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20001215)88:6<992::AID-IJC24>3.0.CO;2-9     Document Type: Article

References (21)

1. Retinoblastoma protein recruits histone deacetylase to repress transcription
2. The regulation of E2F by pRB-family proteins
3. Three proteins define a class of human histone deacetylases related to yeast Hdalp
4. Effect of 9-cis-retinoic acid on oral squamous cell carcinoma cell lines
5. Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines
6. Growth inhibitory effect of interferon-β is associated with the induction of cyclin-dependent kinase inhibitor p27(kip1) in a human gastric carcinoma cell line
7. Functional interplay between p53 and E2F through co-activator p300
8. Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors
9. Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): Dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway
10. Growth inhibition of cultured human gastric cancer cells by 9-cis-retinoic acid with induction of cdk inhibitor Waf1/Cip1/Sdi1/p21 protein
11. Growth-promoting effect of gastrin on human gastric carcinoma cell line TMK-1
12. A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors
13. Expression of the E2F family in human gastrointestinal carcinomas
14. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
15. E2F-1 and E1A(12S) have a homologous activation domain regulated by RB and CBP
16. A new antifungal antibiotic, trichostatin
17. Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family
18. Expression of cell cycle regulating transcription factor E2F-1 in colorectal carcinomas
19. Reduced expression of cyclin-dependent kinase inhibitor p27(kip1) is associated with advanced stage and invasiveness of gastric carcinomas
20. Reversible arrest of proliferation of rat 3Y1 fibroblasts in both the G1 and G2 phases by trichostatin A
21. Effects of trichostatins on differentiation of murine erythroleukemia cells