Real-time monitoring of metabolic reactions by microdialysis in combination with tandem mass spectrometry: Hydrolysis of CS-866 in vitro in human and rat plasma, livers, and small intestines

Analytical Biochemistry

Volumn 287, Issue 2, 2000, Pages 272-278

  Kobayashi, Nobuhiro ^a   Fujimori, Izumi ^a   Watanabe, Misa ^a   Ikeda, Toshihiko ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

CS 866; Microdialysis; Real time analysis; RNH 6270; Tandem mass spectrometry

Indexed keywords

DATA ACQUISITION; DIALYSIS; FLOW RATE; HYDROLYSIS; ION SOURCES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; METHANOL; PLASMA (HUMAN);

CHROMATOGRAPHIC SEPARATIONS; COEFFICIENT OF VARIATION; INTRA-ASSAY PRECISION; MICRO-DIALYSIS; REAL TIME ANALYSIS; RNH-6270; SUBSTANTIAL REDUCTION; TANDEM MASS SPECTROMETRY;

RATS;

ANGIOTENSIN 2 RECEPTOR ANTAGONIST; INORGANIC COMPOUND; METHANOL; OLMESARTAN; RHN 6270; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL TISSUE; ARTICLE; CALIBRATION; CHEMICAL REACTION; CHROMATOGRAPHY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIALYSATE; DRUG STRUCTURE; EXTRACTION; FLOW RATE; HALF LIFE TIME; HUMAN; HUMAN TISSUE; HYDROLYSIS; IN VITRO STUDY; LIPOPHILICITY; LIVER; METABOLISM; METABOLITE; MICRODIALYSIS; MONITORING; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT; SMALL INTESTINE; SPECIES DIFFERENCE; TANDEM MASS SPECTROMETRY;

ANIMALIA;

EID: 0034672196     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1006/abio.2000.4840     Document Type: Article

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