메뉴 건너뛰기




Volumn 277, Issue 1, 1996, Pages 551-558

Tolerance of hypothalamic β-endorphin neurons to μ-opioid receptor activation after chronic morphine

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; BETA ENDORPHIN; DELTA OPIATE RECEPTOR; MORPHINE; PLACEBO;

EID: 0030437250     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (26)

References (51)
  • 1
    • 0018133542 scopus 로고
    • Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine
    • AGHAJANIAN, G. K.: Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine. Nature 276: 186-188, 1978.
    • (1978) Nature , vol.276 , pp. 186-188
    • Aghajanian, G.K.1
  • 2
    • 0023258910 scopus 로고
    • 2- and opiate effector mechanisms in the locus coeruleus: Intracellular studies in brain slices
    • 2- and opiate effector mechanisms in the locus coeruleus: Intracellular studies in brain slices. Neuropharmacology 26: 793-799, 1987.
    • (1987) Neuropharmacology , vol.26 , pp. 793-799
    • Aghajasian, G.K.1    Wang, Y.-Y.2
  • 3
    • 0026333419 scopus 로고
    • Opiate withdrawal-induced hyperactivity of locus coeruleus neurons in substantially mediated by augmented excitatory amino acid input
    • AKAOKA, H. AND ASTON-JONES, G.: Opiate withdrawal-induced hyperactivity of locus coeruleus neurons in substantially mediated by augmented excitatory amino acid input. J. Neurosci. 11: 3830-3839, 1991.
    • (1991) J. Neurosci. , vol.11 , pp. 3830-3839
    • Akaoka, H.1    Aston-Jones, G.2
  • 4
    • 0023129236 scopus 로고
    • Rewarding properties of β-endorphin as measured by conditioned place preference
    • AMALRIC, M., CLINE, E. J., MARTINEZ, J. L., JR., BLOOM, F. E. AND KOOB, G. F.: Rewarding properties of β-endorphin as measured by conditioned place preference. Psychopharmacology 91: 14-19, 1987
    • (1987) Psychopharmacology , vol.91 , pp. 14-19
    • Amalric, M.1    Cline, E.J.2    Martinez Jr., J.L.3    Bloom, F.E.4    Koob, G.F.5
  • 5
    • 0020501879 scopus 로고
    • Morphine tolerance and dependence in the locus coeruleus: Single cell studies in brain slices
    • ANDRADE, R., VANDERMAELEN, C. P. AND AGHAJANIAN, G K.: Morphine tolerance and dependence in the locus coeruleus: Single cell studies in brain slices. Eur. J. Pharmacol. 91: 161-169, 1983.
    • (1983) Eur. J. Pharmacol. , vol.91 , pp. 161-169
    • Andrade, R.1    Vandermaelen, C.P.2    Aghajanian, G.K.3
  • 6
    • 0023510867 scopus 로고
    • Cellular mechanisms of opioid tolerance: Studies in single brain neurons
    • CHRISTIE, M. J., WILLIAMS, J. T. AND NORTH, R. A.: Cellular mechanisms of opioid tolerance: Studies in single brain neurons. Mol Pharmacol. 32: 633-638, 1987.
    • (1987) Mol Pharmacol. , vol.32 , pp. 633-638
    • Christie, M.J.1    Williams, J.T.2    North, R.A.3
  • 8
    • 0021223345 scopus 로고
    • The hypothalamic control of the menstrual cycle and the role of endogenous opioid peptides
    • FERIN, M., VAN VUGT, D. AND WARDLAW, S. The hypothalamic control of the menstrual cycle and the role of endogenous opioid peptides. Recent Prog. Horm. Res. 40: 441-485, 1984.
    • (1984) Recent Prog. Horm. Res. , vol.40 , pp. 441-485
    • Ferin, M.1    Van Vugt, D.2    Wardlaw, S.3
  • 10
    • 0015698401 scopus 로고
    • Morphine-tolerant longitudinal muscle strip from guinea-pig ileum
    • GOLDSTEIN, A. AND SCHULZ, R.: Morphine-tolerant longitudinal muscle strip from guinea-pig ileum. Br. J. Pharmacol. 48: 655-666, 1973.
    • (1973) Br. J. Pharmacol. , vol.48 , pp. 655-666
    • Goldstein, A.1    Schulz, R.2
  • 11
    • 0027472734 scopus 로고
    • Second messenger and protein phosphorylation mechanisms underlying opiate addiction: Studies in the rat locus coeruleus
    • GUITART, X. AND NESTLER, E. J.: Second messenger and protein phosphorylation mechanisms underlying opiate addiction: Studies in the rat locus coeruleus. Neurochem. Res. 18: 5-13, 1993.
    • (1993) Neurochem. Res. , vol.18 , pp. 5-13
    • Guitart, X.1    Nestler, E.J.2
  • 12
    • 0025347712 scopus 로고
    • Phosphorylated μ-opioid receptor purified from rat brains lacks functional coupling with Gil, a GTP-binding protein in reconstituted lipid vesicles
    • HARADA, H., UEDA, H., KATADA, T., UI, M. AND SATOH, M.: Phosphorylated μ-opioid receptor purified from rat brains lacks functional coupling with Gil, a GTP-binding protein in reconstituted lipid vesicles. Neurosci. Lett. 113: 47-49, 1990.
    • (1990) Neurosci. Lett. , vol.113 , pp. 47-49
    • Harada, H.1    Ueda, H.2    Katada, T.3    Ui, M.4    Satoh, M.5
  • 13
    • 0025938571 scopus 로고
    • Transient homologous μ-opioid receptor desensitization in rat locus coeruleus neurons
    • HARRIS, G. C. AND WILLIAMS, J. T.: Transient homologous μ-opioid receptor desensitization in rat locus coeruleus neurons. J. Neurosci. 11: 2574-2581, 1991.
    • (1991) J. Neurosci. , vol.11 , pp. 2574-2581
    • Harris, G.C.1    Williams, J.T.2
  • 14
    • 0019431836 scopus 로고
    • Iontophoresis of morphine into the arcuate nucleus: Effects on dopamine concentrations in hypophysial portal plasma and serum prolactin concentrations
    • HASKINS, J. T., GUDELSKY, G. A., MOSS, R. L. AND PORTER, J. C.: Iontophoresis of morphine into the arcuate nucleus: Effects on dopamine concentrations in hypophysial portal plasma and serum prolactin concentrations. Endocrinology 108: 767-771, 1981.
    • (1981) Endocrinology , vol.108 , pp. 767-771
    • Haskins, J.T.1    Gudelsky, G.A.2    Moss, R.L.3    Porter, J.C.4
  • 15
    • 0018825446 scopus 로고
    • Effects of naloxone and morphine on the proestrous surge of prolactin and gonadotropins in the rat
    • IEIRI, T., CHEN, H. T., CAMPBELL, G. A. AND MEITES, J.: Effects of naloxone and morphine on the proestrous surge of prolactin and gonadotropins in the rat. Endocrinology 106: 1568-1570, 1980.
    • (1980) Endocrinology , vol.106 , pp. 1568-1570
    • Ieiri, T.1    Chen, H.T.2    Campbell, G.A.3    Meites, J.4
  • 16
    • 0019785683 scopus 로고
    • Neural loci involved in naloxone-induced luteinizing hormone release: Effects of a norepinephrine synthesis inhibitor
    • KALRA, S. P.: Neural loci involved in naloxone-induced luteinizing hormone release: Effects of a norepinephrine synthesis inhibitor. Endocrinology 109: 1805-1810, 1981.
    • (1981) Endocrinology , vol.109 , pp. 1805-1810
    • Kalra, S.P.1
  • 17
    • 0021276851 scopus 로고
    • Opioid-adrenergic-steroid connection in regulation of luteinizing hormone secretion in the rat
    • KALRA, S. P. AND KALRA, P. S.: Opioid-adrenergic-steroid connection in regulation of luteinizing hormone secretion in the rat. Neuroendocrinology 38: 418-426, 1984.
    • (1984) Neuroendocrinology , vol.38 , pp. 418-426
    • Kalra, S.P.1    Kalra, P.S.2
  • 18
    • 0025108381 scopus 로고
    • Opioids hyperpolarize β-endorphin neurons via μ-receptor activation of a potassium conductance
    • KELLY, M. J., LOOSE, M. D. AND RONNEKLEIV, O. K.: Opioids hyperpolarize β-endorphin neurons via μ-receptor activation of a potassium conductance. Neuroendocrinology 52: 268-275, 1990.
    • (1990) Neuroendocrinology , vol.52 , pp. 268-275
    • Kelly, M.J.1    Loose, M.D.2    Ronnekleiv, O.K.3
  • 19
  • 20
    • 0028153216 scopus 로고
    • Tolerance in hypothalamic β-endorphin neurons following chronic morphine
    • KELLY, M. J., ZHANG, G., LAGRANGE, A. H. AND RØNNEKLEIV, O. K.: Tolerance in hypothalamic β-endorphin neurons following chronic morphine. Regul. Peptides 54: 145-146, 1994.
    • (1994) Regul. Peptides , vol.54 , pp. 145-146
    • Kelly, M.J.1    Zhang, G.2    Lagrange, A.H.3    Rønnekleiv, O.K.4
  • 21
    • 0026345669 scopus 로고
    • μ-Opioid receptor inhibition of calcium current: Development of homologous tolerance in single SH-SY5Y cells after chronic exposure to morphine in vitro
    • KENNEDY, C. AND HENDERSON, G.: μ-Opioid receptor inhibition of calcium current: Development of homologous tolerance in single SH-SY5Y cells after chronic exposure to morphine in vitro. Mol Pharmacol. 40: 1000-1005, 1991.
    • (1991) Mol Pharmacol. , vol.40 , pp. 1000-1005
    • Kennedy, C.1    Henderson, G.2
  • 22
    • 0022517599 scopus 로고
    • Morphine or capsaicin administration alters the secretion of β-endorphin into the hypophysial portal vasculature of the rat
    • KOENIG, J. I., MELTZER, H. Y. AND GUDELSKY, G. A.: Morphine or capsaicin administration alters the secretion of β-endorphin into the hypophysial portal vasculature of the rat. Neuroendocrinology 43: 611-617, 1986.
    • (1986) Neuroendocrinology , vol.43 , pp. 611-617
    • Koenig, J.I.1    Meltzer, H.Y.2    Gudelsky, G.A.3
  • 23
    • 0026507628 scopus 로고
    • Drugs of abuse: Anatomy, pharmacology and function of reward pathways
    • KOOB, G. F.: Drugs of abuse: Anatomy, pharmacology and function of reward pathways. Trends Pharm. Sci. 13: 177-184, 1992.
    • (1992) Trends Pharm. Sci. , vol.13 , pp. 177-184
    • Koob, G.F.1
  • 24
    • 0020682559 scopus 로고
    • Behavioral effects of opioid peptides
    • KOOB, G. F. AND BLOOM, F. E.: Behavioral effects of opioid peptides. Br. Med. Bull. 39: 89-94, 1983.
    • (1983) Br. Med. Bull. , vol.39 , pp. 89-94
    • Koob, G.F.1    Bloom, F.E.2
  • 25
    • 0026477667 scopus 로고
    • Brain mechanisms of drug-induced reinforcement
    • ed. by C. P. O'Brien and J. H. Jaffe, Raven Press, Ltd., New York
    • KORNETSKY, C. AND PORRINO, L. J.: Brain mechanisms of drug-induced reinforcement. In Addictive States, ed. by C. P. O'Brien and J. H. Jaffe, pp. 59-77, Raven Press, Ltd., New York, 1992.
    • (1992) Addictive States , pp. 59-77
    • Kornetsky, C.1    Porrino, L.J.2
  • 26
    • 0028169621 scopus 로고
    • The potency of μ-opioid hyperpolarization of hypothalamic arcuate neurons is rapidly attenuated by 17β-estradiol
    • LAGRANGE, A. H., RONNEKLEIV, O. K. AND KELLY, M. J.: The potency of μ-opioid hyperpolarization of hypothalamic arcuate neurons is rapidly attenuated by 17β-estradiol. J. Neurosci. 14: 6196-6204, 1994.
    • (1994) J. Neurosci. , vol.14 , pp. 6196-6204
    • Lagrange, A.H.1    Ronnekleiv, O.K.2    Kelly, M.J.3
  • 27
    • 0028985842 scopus 로고
    • Estradiol-17β and μ-opioid peptides rapidly hyperpolarize GnRH neurons: A cellular mechanism of negative feedback?
    • LAGRANGE, A. H., ROØNNEKLEIV, O. K AND KELLY, M. J.: Estradiol-17β and μ-opioid peptides rapidly hyperpolarize GnRH neurons: A cellular mechanism of negative feedback? Endocrinology 136: 2341-2344, 1995.
    • (1995) Endocrinology , vol.136 , pp. 2341-2344
    • Lagrange, A.H.1    Roønnekleiv, O.K.2    Kelly, M.J.3
  • 28
    • 0021052541 scopus 로고
    • Opiate receptor down-regulation and desensitization in neuroblastoma X glioma NG108-15 hybrid cells are two separate cellular adaptation processes
    • LAW, P. Y., HOM, D. S. AND LOH, H. H.: Opiate receptor down-regulation and desensitization in neuroblastoma X glioma NG108-15 hybrid cells are two separate cellular adaptation processes. Mol. Pharmacol. 24: 413-424, 1983.
    • (1983) Mol. Pharmacol. , vol.24 , pp. 413-424
    • Law, P.Y.1    Hom, D.S.2    Loh, H.H.3
  • 29
    • 0021840443 scopus 로고
    • Effects of endogenous opioid peptides and opiates on luteinizing hormone and prolactin secretion in ovariectomized rats
    • LEADEM, C. A. AND KALRA, S. P.: Effects of endogenous opioid peptides and opiates on luteinizing hormone and prolactin secretion in ovariectomized rats. Neuroendocrinology 41: 342-352, 1985.
    • (1985) Neuroendocrinology , vol.41 , pp. 342-352
    • Leadem, C.A.1    Kalra, S.P.2
  • 30
    • 0025514318 scopus 로고
    • Membrane properties and response to opioids of identified dopamine neurons in the guinea pig hypothalamus
    • LOOSE, M. D., RONNEKLEIV, O. K. AND KELLY, M. J.: Membrane properties and response to opioids of identified dopamine neurons in the guinea pig hypothalamus. J. Neurosci. 10: 3627-3634, 1990.
    • (1990) J. Neurosci. , vol.10 , pp. 3627-3634
    • Loose, M.D.1    Ronnekleiv, O.K.2    Kelly, M.J.3
  • 31
    • 0026046455 scopus 로고
    • B and μ-opioid receptor agonists: Evidence for convergence at a ligand-gated potassium conductance
    • B and μ-opioid receptor agonists: evidence for convergence at a ligand-gated potassium conductance. Neuroendocrinology 54: 537-544, 1991.
    • (1991) Neuroendocrinology , vol.54 , pp. 537-544
    • Loose, M.D.1    Ronnekleiv, O.K.2    Kelly, M.J.3
  • 32
    • 0025260394 scopus 로고
    • Opioids act at μ-receptors to hyperpolarize arcuate neurons via an inwardly rectifying potassium conductance
    • LOOSE, M. D. AND KELLY, M. J.: Opioids act at μ-receptors to hyperpolarize arcuate neurons via an inwardly rectifying potassium conductance. Brain Res. 513: 15-23, 1990.
    • (1990) Brain Res. , vol.513 , pp. 15-23
    • Loose, M.D.1    Kelly, M.J.2
  • 34
    • 0027304846 scopus 로고
    • A stereospecific microassay for the determination of morphine-6-β-D-glucuronide and other active morphine metabolites in the neonatal guinea pig
    • MURPHEY, L. J. AND OLSEN, G. D.: A stereospecific microassay for the determination of morphine-6-β-D-glucuronide and other active morphine metabolites in the neonatal guinea pig. J. Liquid Chromatog. 16: 2545-2561, 1993.
    • (1993) J. Liquid Chromatog. , vol.16 , pp. 2545-2561
    • Murphey, L.J.1    Olsen, G.D.2
  • 35
    • 0026645205 scopus 로고
    • Molecular mechanisms of drug addiction
    • NESTLER, E. J.: Molecular mechanisms of drug addiction. J. Neurosci. 12: 2439-2450, 1992
    • (1992) J. Neurosci. , vol.12 , pp. 2439-2450
    • Nestler, E.J.1
  • 36
    • 0023270771 scopus 로고
    • Feedback inhibition of opioid peptide release in the hypothalamus of the rat
    • NIKOLARAKIS, K. E., ALMEIDA, O. F. X. AND HERZ, A.: Feedback inhibition of opioid peptide release in the hypothalamus of the rat. Neuroscience 23: 143-148, 1987.
    • (1987) Neuroscience , vol.23 , pp. 143-148
    • Nikolarakis, K.E.1    Almeida, O.F.X.2    Herz, A.3
  • 37
    • 0005353339 scopus 로고
    • μ and δ receptors belong to a family of receptors that are coupled to potassium channels
    • NORTH, R. A., WILLIAMS, J, T., SURPRENANT, A. ANO CHRISTIE, M. J.: μ and δ receptors belong to a family of receptors that are coupled to potassium channels. Proc. Natl. Acad. Sci. U.S.A. 84: 5487-5491, 1987.
    • (1987) Proc. Natl. Acad. Sci. U.S.A. , vol.84 , pp. 5487-5491
    • North, R.A.1    Williams, J.T.2    Surprenant, A.3    Christie, M.J.4
  • 38
    • 0027520252 scopus 로고
    • Endogenous opiates: 1992
    • OLSON, G. A., OLSON, R. D. AND KASTIN, A. J.: Endogenous opiates: 1992. Peptides 14: 1339-1378, 1993.
    • (1993) Peptides , vol.14 , pp. 1339-1378
    • Olson, G.A.1    Olson, R.D.2    Kastin, A.J.3
  • 39
    • 0023947260 scopus 로고
    • Effects of chronic morphine exposure on opioid inhibition of adenylyl cyclase in 7315c cell membranes: A useful model for the study of tolerance at μ opioid receptors
    • PUTTFARCKEN, P. S., WERLING, L. L. AND COX, B. M.: Effects of chronic morphine exposure on opioid inhibition of adenylyl cyclase in 7315c cell membranes: A useful model for the study of tolerance at μ opioid receptors. Mol. Pharmacol. 33: 520-527, 1988.
    • (1988) Mol. Pharmacol. , vol.33 , pp. 520-527
    • Puttfarcken, P.S.1    Werling, L.L.2    Cox, B.M.3
  • 40
    • 0025457883 scopus 로고
    • Opiate withdrawal and the rat locus coeruleus: Behavioral, electrophysiological, and biochemical correlates
    • RASMUSSEN, K., BEITNER-JOHNSON, D. B., KRYSTAL, J. H., AGHAJANIAN, G. K. AND NESTLER, E. J.: Opiate withdrawal and the rat locus coeruleus: Behavioral, electrophysiological, and biochemical correlates. J. Neurosci. 10: 2308-2317, 1990.
    • (1990) J. Neurosci. , vol.10 , pp. 2308-2317
    • Rasmussen, K.1    Beitner-Johnson, D.B.2    Krystal, J.H.3    Aghajanian, G.K.4    Nestler, E.J.5
  • 41
    • 0025169128 scopus 로고
    • A method for immunocytochemical identification of biocytin-labeled neurons following intracellular recording
    • RONNEKLEIV, O. K., LOOSE, M. D., ERICKSON, K. R. AND KELLY, M. J.: A method for immunocytochemical identification of biocytin-labeled neurons following intracellular recording. BioTechniques 9: 432-438, 1990.
    • (1990) BioTechniques , vol.9 , pp. 432-438
    • Ronnekleiv, O.K.1    Loose, M.D.2    Erickson, K.R.3    Kelly, M.J.4
  • 42
    • 0023693112 scopus 로고
    • Role of endogenous opioid peptides in the initiation of the midcycle luteinizing hormone surge in normal cycling women
    • ROSSMANITH, W. G., MORTOLA, J. F. AND YEN, S. S. C.: Role of endogenous opioid peptides in the initiation of the midcycle luteinizing hormone surge in normal cycling women. J. Clin. Endocrinol. Metab. 67: 695-700, 1988.
    • (1988) J. Clin. Endocrinol. Metab. , vol.67 , pp. 695-700
    • Rossmanith, W.G.1    Mortola, J.F.2    Yen, S.S.C.3
  • 43
    • 0028153892 scopus 로고
    • Effects of estrogen on the number of neurons expressing β-endorphin in the medial basal hypothalamus of the female guinea pig
    • THORNTON, J. E., LOOSE, M. D., KELLY, M. J. AND RONNEKLEIV, O. K.: Effects of estrogen on the number of neurons expressing β-endorphin in the medial basal hypothalamus of the female guinea pig. J. Comp. Neurol. 341: 68-77, 1994.
    • (1994) J. Comp. Neurol. , vol.341 , pp. 68-77
    • Thornton, J.E.1    Loose, M.D.2    Kelly, M.J.3    Ronnekleiv, O.K.4
  • 44
    • 0018754630 scopus 로고
    • Dependence creating properties of lipotropin c-fragment: Evidence for its internal control of behavior
    • VAN REE, J. M., SMYTH, D. G. AND COLPAERT, F. C.: Dependence creating properties of lipotropin c-fragment: Evidence for its internal control of behavior. Life Sci. 24: 495-502, 1979.
    • (1979) Life Sci. , vol.24 , pp. 495-502
    • Van Ree, J.M.1    Smyth, D.G.2    Colpaert, F.C.3
  • 45
    • 0021338316 scopus 로고
    • Site of action for β-endorphin-induced changes in plasma luteinizing hormone and prolactin in the ovariectomized rat
    • WEISNER, J. B , KOENIG, J. I., KRULICH, L. AND MOSS, R. L.: Site of action for β-endorphin-induced changes in plasma luteinizing hormone and prolactin in the ovariectomized rat. Life Sci. 34: 1463-1473, 1984.
    • (1984) Life Sci. , vol.34 , pp. 1463-1473
    • Weisner, J.B.1    Koenig, J.I.2    Krulich, L.3    Moss, R.L.4
  • 46
    • 0013636518 scopus 로고
    • Selective changes in μ opioid receptor properties induced by chronic morphine exposure
    • WERLING, L. L., MCMAHON, P. N. AND COX, B. M.: Selective changes in μ opioid receptor properties induced by chronic morphine exposure. Proc. Natl. Acad. Sci. U.S.A. 86: 6393-6397, 1989.
    • (1989) Proc. Natl. Acad. Sci. U.S.A. , vol.86 , pp. 6393-6397
    • Werling, L.L.1    Mcmahon, P.N.2    Cox, B.M.3
  • 47
    • 0021715347 scopus 로고
    • Opiate-receptor interactions on single locus coeruleus neurones
    • WILLIAMS, J. T. AND NORTH, R. A.: Opiate-receptor interactions on single locus coeruleus neurones. Mol. Pharmacol. 26: 489-497, 1984.
    • (1984) Mol. Pharmacol. , vol.26 , pp. 489-497
    • Williams, J.T.1    North, R.A.2
  • 48
    • 0026681670 scopus 로고
    • Continuous intrathecal opioid treatment abolishes the regulatory effects of magnesium and guanine nucleotides on mu opioid receptor binding in rat spinal membranes
    • WONG, C.-S., SU, Y.-F., WATKINS, W. D. AND CHANG, K.-J.: Continuous intrathecal opioid treatment abolishes the regulatory effects of magnesium and guanine nucleotides on mu opioid receptor binding in rat spinal membranes. J. Pharmacol. Exp. Ther. 262: 317-326, 1992.
    • (1992) J. Pharmacol. Exp. Ther. , vol.262 , pp. 317-326
    • Wong, C.-S.1    Su, Y.-F.2    Watkins, W.D.3    Chang, K.-J.4
  • 49
    • 0027520098 scopus 로고
    • Mu opiate receptor down-regulation by morphine and up-regulation by naloxone in SH-SY5Y human neuroblastoma cells
    • ZADINA, J. E., CHANG, S. L., GE, L.-J. AND KASTIN, A. J.: Mu opiate receptor down-regulation by morphine and up-regulation by naloxone in SH-SY5Y human neuroblastoma cells. J. Pharmacol. Exp. Ther. 265: 254-262, 1993.
    • (1993) J. Pharmacol. Exp. Ther. , vol.265 , pp. 254-262
    • Zadina, J.E.1    Chang, S.L.2    Ge, L.-J.3    Kastin, A.J.4
  • 50
    • 0345484830 scopus 로고
    • Effect of estrogen on μ-opioid receptor G-protein coupling in guinea-pig mediobasal hypothalamus (MBH)
    • ZHANG, G , MURRAY, T. F. AND KELLY, M. J.: Effect of estrogen on μ-opioid receptor G-protein coupling in guinea-pig mediobasal hypothalamus (MBH). Soc. Neurosci. Abstr. 19: 1154, 1993.
    • (1993) Soc. Neurosci. Abstr. , vol.19 , pp. 1154
    • Zhang, G.1    Murray, T.F.2    Kelly, M.J.3
  • 51
    • 12644295888 scopus 로고
    • Chronic morphine down-regulates μ-opioid receptors in guinea-pig mediobasal hypothalamus (MBH)
    • ZHANG, G , BOSCH, M A. AND KELLY, M. J.. Chronic morphine down-regulates μ-opioid receptors in guinea-pig mediobasal hypothalamus (MBH). Soc. Neurosci. Abstr. 20: 1728, 1994.
    • (1994) Soc. Neurosci. Abstr. , vol.20 , pp. 1728
    • Zhang, G.1    Bosch, M.A.2    Kelly, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.