Structural and functional analysis of the riboflavin synthesis genes encoding GTP cyclohydrolase II (ribA), DHBP synthase (ribBA), riboflavin synthase (ribC), and riboflavin deaminase/reductase (ribD) from Helicobacter pylori strain P1

FEMS Microbiology Letters

Volumn 191, Issue 2, 2000, Pages 191-197

  Fassbinder, Frank ^a   Kist, Manfred ^a   Bereswill, Stefan ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Cofactor synthesis; Flavin adenine dinucleotide; Helicobacter pylori; NAD; Vitamin B2

Indexed keywords

GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE II; IRON; RIBOFLAVIN; RIBOFLAVIN DEAMINASE; RIBOFLAVIN REDUCTASE; RIBOFLAVIN SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL METABOLISM; CONTROLLED STUDY; GENE STRUCTURE; HELICOBACTER PYLORI; HEMOLYSIS; NONHUMAN; PRIORITY JOURNAL;

AMINOHYDROLASES; BACTERIAL PROTEINS; CLONING, MOLECULAR; DNA TRANSPOSABLE ELEMENTS; ESCHERICHIA COLI; FLUORESCENCE; GENES, BACTERIAL; GENETIC COMPLEMENTATION TEST; GTP CYCLOHYDROLASE; HELICOBACTER PYLORI; HEMOLYSIS; IRON; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; RIBOFLAVIN; RIBOFLAVIN SYNTHASE; SUGAR PHOSPHATES; SUPPORT, NON-U.S. GOV'T; TRANSFORMATION, BACTERIAL;

ESCHERICHIA COLI; HELICOBACTER PYLORI;

EID: 0034668291     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(00)00389-X     Document Type: Article

References (18)

1. Bacher, A., Eberhardt, S. and Richter, G. (1996) Biosynthesis of riboflavin. In: Escherichia coli and Salmonella typhimurium, Cellular and Molecular Biology (Neidhart, F.C., Ed.), pp. 657-664. American Society for Microbiology, Washington, DC.
2. Dunn B.E., Cohen H., Blaser M.J. Helicobacter pylori. Clin. Microbiol. Rev. 10:1997;720-741.
3. Tomb J.F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.P., Gill S., Dougherty B.A., Nelson K., Quackenbush J., Zhou L., Kirkness E.F., Peterson S., Loftus B., Richardson D., Dodson R., Khalak H.G., Glodek A., McKenney K., Fitzegerald L.M., Lee N., Adams M.D., Venter J.C. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature. 388:1997;539-547.
4. Alm R.A., Ling L.S., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D., Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature. 397:1999;176-180.
5. Worst D.J., Gerrits M.M., Vandenbroucke-Grauls C.M., Kusters J.G. Helicobacter pylori ribBA-mediated riboflavin production is involved in iron acquisition. J. Bacteriol. 180:1998;1473-1479.
6. Bereswill S., Fassbinder F., Voelzing C., Covacci A., Haas R., Kist M. Hemolytic properties and riboflavin synthesis of Helicobacter pylori: cloning and functional characterization of the ribA gene encoding GTP-cyclohydrolase II that confers hemolytic activity to Escherichia coli. Med. Microbiol. Immunol. 186:1998;177-187.
7. Parkhill J., Wren B.W., Mungall K., Ketley J.M., Churcher C., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.-A., Rutherford K.M., van Vliet A.H.M., Whitehead S., Barrell B.G. The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences. Nature. 403:2000;665-668.
8. Richter G., Ritz H., Katzenmeier G., Volk R., Kohnle A., Lottspeich F., Allendorf D., Bacher A. Biosynthesis of riboflavin: cloning, sequencing, mapping, and expression of the gene coding for GTP cyclohydrolase II in Escherichia coli. J. Bacteriol. 175:1993;4045-4051.
9. Bacher A., Richter G., Ritz H., Eberhardt S., Fischer M., Krieger C. Biosynthesis of riboflavin: GTP cyclohydrolase II, deaminase, and reductase. Methods Enzymol. 280:1997;382-389.
10. Richter G., Volk R., Krieger C., Lahm H.W., Rothlisberger U., Bacher A. Biosynthesis of riboflavin: cloning, sequencing, and expression of the gene coding for 3,4-dihydroxy-2-butanone 4-phosphate synthase of Escherichia coli. J. Bacteriol. 174:1992;4050-4056.
11. Richter G., Fischer M., Krieger C., Eberhardt S., Luttgen H., Gerstenschlager I., Bacher A. Biosynthesis of riboflavin: characterization of the bifunctional deaminase-reductase of Escherichia coli and Bacillus subtilis. J. Bacteriol. 179:1997;2022-2028.
12. Eberhardt S., Richter G., Gimbel W., Werner T., Bacher A. Cloning, sequencing, mapping and hyperexpression of the ribC gene coding for riboflavin synthase of Escherichia coli. Eur. J. Biochem. 242:1996;712-719.
13. Bereswill S., Fassbinder F., Voelzing C., Haas R., Reuter K., Ficner R., Kist M. Cloning and functional characterization of the genes encoding 3-dehydroquinate synthase (aroB) and tRNA-guanine transglycosylase (tgt) from Helicobacter pylori. Med. Microbiol. Immunol. 186:1997;125-134.
14. Bereswill S., Hinkelmann S., Kist M., Sander A. Molecular analysis of riboflavin synthesis genes in Bartonella henselae and use of the ribC gene for differentiation of Bartonella species by PCR. J. Clin. Microbiol. 37:1999;3159-3166.
15. Odenbreit S., Till M., Haas R. Optimized BlaM-transposon shuttle mutagenesis of Helicobacter pylori allows the identification of novel genetic loci involved in bacterial virulence. Mol. Microbiol. 20:1996;361-373.
16. Oscarsson J., Mizunoe Y., Uhlin B.E., Haydon D.J. Induction of haemolytic activity in Escherichia coli by the slyA gene product. Mol. Microbiol. 20:1996;191-199.
17. Fuller T.E., Thacker B.J., Mulks M.H. A riboflavin auxotroph of of Actinobacillus pleuropneumoniae is attenuated in swine. Infect. Immun. 64:1996;4659-4664.
18. Zimmermann L., Angerer A., Braun V. Mechanistically novel iron-III transport system in Serratia marcescens. J. Bacteriol. 171:1989;238-243.