Mitochondrial K(ATP) channels: Triggers or distal effectors of ischemic or pharmacological preconditioning?

Circulation Research

Volumn 87, Issue 6, 2000, Pages 431-433

  Gross, Garrett J ^a   Fryer, Ryan M ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Diazoxide; K(ATP) channels; Mitochondria; Preconditioning

Indexed keywords

1,2,3,4,4A,5,12,12AALPHA OCTAHYDRO 4AALPHA (3 HYDROXYPHENYL) 2 METHYLQUINOLINO[2,3 G]ISOQUINOLINE; 12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 CHLORO 6 N CYCLOPENTYLADENOSINE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 5 HYDROXYDECANOIC ACID; ADENOSINE; CHELERYTHRINE; DAIDZEIN; DELTA OPIATE RECEPTOR ANTAGONIST; DIADENOSINE TETRAPHOSPHATE; DIAZOXIDE; GENISTEIN; GLIBENCLAMIDE; PHORBOL ESTER; PINACIDIL; POTASSIUM CHANNEL; POTASSIUM CHANNEL AFFECTING AGENT; POTASSIUM ION; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE;

EDITORIAL; ENZYME ACTIVATION; HEART INFARCTION PREVENTION; HEART MITOCHONDRION; HEART PROTECTION; HUMAN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0034665260     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.87.6.431     Document Type: Editorial

References (36)

1. Opening of mitochondrial K(ATP) channels triggers the preconditioned state by generating free radicals
2. Ischemic preconditioning depends on interaction between mitochondrial K(ATP) channels and actin cytoskeleton
3. Blockade of the ATP-sensitive potassium channels prevents myocardial preconditioning
4. K(ATP) channels and memory of ischemic preconditioning in dogs: Synergism between adenosine and K(ATP) channels
5. Ischemic preconditioning in rats: Role for the mitochondrial K(ATP) channel in the preservation of mitochondrial function
6. Opening of mitochondrial K(ATP) channel induces early and delayed cardioprotective effect: Role of nitric oxide
7. Protein kinase C-mediated preconditioning of cardiac myocytes: Role of adenosine receptor and K(ATP) channel
8. Protein kinase C-dependent activation of K(ATP) channel enhances adenosine-induced cardioprotection
9. Dual roles of mito-K(ATP) in diazoxide-mediated protection in rabbit hearts
10. Delayed cardioprotection in a human cardiomyocyte-derived cell line: The role of adenosine, p38 MAP kinase and mitochondrial K(ATP)
11. Myocardial ischemic tolerance following heat stress is abolished by ATP-sensitive potassium channel blockade
12. Resistance to myocardial infarction induced by heat stress and the effect of ATP-sensitive potassium channel blockade in the rat isolated heart
13. Opioid-induced second window of cardioprotection: Potential role of mitochondrial K(ATP) channels
14. + channels in rabbit heart
15. 1 receptor activation
16. Evidence that translocation of protein kinase C is a key event during ischemic preconditioning of rabbit myocardium
17. Arguments in favor of protein kinase C playing an important role in ischemic preconditioning
18. Protein kinase C-ε is responsible for the protection of preconditioning in rabbit cardiomyocytes
19. Preconditioning protects ischemic rabbit heart by protein kinase C activation
20. Protection of ischemic preconditioning is dependant upon a critical timing sequence of protein kinase C activation
21. Protein tyrosine kinase is downstream of protein kinase C for ischemic preconditioning's anti-infarct effect in the rabbit heart
22. Ischemic preconditioning induces selective translocation of protein kinase C isoforms ε and η in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity
23. Isoform-selective activation of protein kinase C by nitric oxide in the heart of conscious rabbits
24. Ischemic preconditioning translocates PKC-δ and -ε, which mediate functional protection in isolated rat hearts
25. Calcium preconditioning elicits strong protection against ischemic injury via a protein kinase C signaling pathway
26. Role of protein kinase C in mitochondrial K(ATP) channel-mediated protection against calcium overload injury in rat myocardium
27. Activation of mitochondrial K(ATP) channel elicits late preconditioning against myocardial infarction via protein kinase C signaling pathway
28. + current in human and rabbit ventricular myocytes
29. + currents by protein kinase C and adenosine: Implications for ischemic preconditioning
30. Diadenosine tetraphosphate (AP4A) mimics cardioprotective effect of ischemic preconditioning in the rat heart: Contribution of K(ATP) channel and PKC
31. Pretreatment with tyrosine kinase inhibitors partially attenuates ischemic preconditioning in the rat heart
32. Demonstration of selective protein kinase C-dependent activation of Src and Lck tyrosine kinases during ischemic preconditioning in conscious rabbits
33. Direct block of voltage-sensitive sodium channels by genistein, a tyrosine kinase inhibitor
34. Genistein inhibits protein histidine kinase
35. Genistein directly induces cardiac CFTR chloride current by a tyrosine kinase-independent and protein kinase A-independent pathway in guinea pig ventricular myocytes
36. Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion