Analysis of the diversity of a sheep antibody repertoire as revealed from a bacteriophage display library

Journal of Immunology

Volumn 164, Issue 12, 2000, Pages 6221-6229

  Charlton, Keith A ^a   Moyle, Sarah ^b   Porter, Andrew J R ^a   Harris, William J ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b Guildhay Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ATRAZINE; HAPTEN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN;

ARTICLE; BACTERIOPHAGE; GENE LIBRARY; GENE LOCUS; GENE TECHNOLOGY; IMMUNIZATION; IMMUNOGENETICS; IMMUNOGLOBULIN GENE; MOLECULAR CLONING; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; SHEEP;

EID: 0034659854     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.12.6221     Document Type: Article

References (47)

1. McCafferty, J., A. D. Griffiths, G. Winter, and D. J. Chiswell. 1990. Phage antibodies: filamentous phage displaying antibody variable domains. Nature 348: 552.
2. Winter, G., A. D. Griffiths, R. E. Hawkins, and H. R. Hoogenboom. 1994. Making antibodies by phage display technology. Annu. Rev. Immunol. 12:433.
3. Vaughan, T. J., A. J. Williams, K. Pritchard, J. K. Osbourn, A. R. Pope, J. C. Earnshaw, J. McCafferty, R. A. Hodits, J. Wilton, and K. S. Johnson. 1996. Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library. Nat. Biotechnol. 14:309.
4. Sawyer, C., J. Embleton, and C. Dear. 1997. Methodology for selection of human antibodies to membrane proteins from a phage-display library. J. Immunol. Methods 204:193.
5. Ridder, R., R. Schmitz, F. Legay, and H. Gram. 1995 Generation of rabbit monoclonal antibody fragments from a combinatorial phage display library and their production in the yeast Pichia pastoris. Bio/Technology 13:255.
6. Davies, E. L., J. S. Smith, C. R. Birkett, J. M. Manser, D. V. Anderson-Dear, and J. R. Young. 1995. Selection of specific phage display antibodies using libraries derived from chicken immunoglobulin genes. J. Immunol. Methods 186:125.
7. Yamanaka, H. I., T. Inoue, and O. Ikeda-Tanaka. 1996. Chicken monoclonal antibody isolated by a phage display system. J. Immunol. 157:1156
8. Clackson, T., H. R. Hoogenboom, A. D. Griffiths, and G. Winter. 1991. Making antibody fragments using phage display libraries. Nature 352:624.
9. Huse, W. D., L. Sastry, S. A. Iverson, A. S. Rang, M. Alting-Mees, D. R. Burton, S. J. Benkovic, and R. A. Lerner. 1989. Generation of a large combinatorial library of the immunoglobulin repertoire in phage A. Science 246:1275.
10. O'Brien, P. M., R. Aitken, B. W. O'Neil, and M. S. Campo. 1999. Generation of native bovine mAbs by phage display. Proc. Natl. Acad. Sci. USA 96:640.
11. H repertoire. Immunol. Today 16:237.
12. Desiderio, S. V., G. D. Yancopoulos, M. Paskind, E. Thomas, M. A. Boss, N. Landau, F. W. Alt, and D. Baltimore. 1984. Insertion of N regions into heavy chain genes is correlated with expression of terminal deoxynucleotidyl transferase in B cells. Nature 311:752.
13. Claman, H. N., E. A. Chaperon, and R. F. Triplett. 1966. Thymus-marrow cell combination: synergisms in antibody production. Proc. Soc. Exp. Biol. Med. 122:1167.
14. Cooper, M. D., R. D. A. Peterson, and R. A. Good. 1965. Delineation of the thymic and bursal lymphoid systems in the chicken. Nature 205:143.
15. Archer, O. K., D. E. R. Sutherland, and R. A. Good. 1963. Appendix of the rabbit: a homologue of the bursa in chicken. Nature 200:337.
16. Reynaud, C. A., C. R. Mackay, R. G. Muller, and J. C. Weill. 1991. Somatic generation of diversity in a mammalian primary lymphoid organ: the sheep ileal Peyer's patches. Cell 64:995.
17. L diversification in cattle. J. Immunol. 161:5438.
18. Weill, J. C., C.-A. Reynaud, O. Lassila, and J. R. L. Pink. 1986. Rearrangement of chicken immunoglobulin genes is not an ongoing process in the embryonic bursa of Fabricius. Proc. Natl. Acad. Sci. USA 83:3336.
19. H family. J. Immunol. 156:2163.
20. H family and long CDRs in the variable region of cattle Ig heavy chains. Int. Immunol. 9:189.
21. H gene family. J. Immunol. 159:3883.
22. H gene family, related to mammalian group I, clan II, is identified in cattle. Mol. Immunol. 34:641.
23. HIII. J. Immunol. 153:5618.
24. Reynaud, C. A., C. Garcia, W. R. Hein, and J. C. Weill. 1995. Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process. Cell 80:115.
25. Parng, C., S. Hansal, R. A. Goldsby, and B. A. Osborne. 1996. Gene conversion contributes to Ig light chain diversity in cattle. J. Immunol. 157:5478.
26. Sun, J., and J. E. Butler. 1996. Molecular characterization of VDJ transcripts from a newborn piglet. Immunology 88:331.
27. H gene of the chicken with a high incidence in the D region. Cell 59:171.
28. Becker, R. S., and K. L. Knight. 1990. Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits. Cell 63:987.
29. Dower, W. J. 1989. High efficiency transformation of E. coli by high voltage electroporation. Nucleic Acids Res. 16:6127.
30. Griffiths, A. D., M. Malmqvist, J. D. Marks, J. M. Bye, M. J. Embleton, J. McCafferty, M. Baier, K. P. Holliger, B. D. Gorick, N. C. Hughes-Jones, et al. 1993. Human anti-self antibodies with high specificity from phage display libraries. EMBO J. 12:725.
31. Chaudhary, V. K., J. K. Batra, M. G. Gallo, M. C. Willingham, D. J. Fitzgerald, and I. Pastan. 1990. A rapid method of cloning functional variable-region antibody genes in Escherichia coli as single-chain immunotoxins. Prof. Natl. Acad. Sci. USA 87:1066.
32. Rabat, E. A., T. T. Wu, H. M. Perry, K. S. Gottesman, and C. Foeller. 1991. Sequences of Proteins of Immunological Interest, 5th Ed. U.S. Department of Health and Human Services, Washington, DC.
33. Clarkson, C. A. 1993. Sequence of ovine IgG2 constant region heavy chain cDNA and molecular modelling of ruminent IgG isotypes. Mol. Immunol. 30: 1195.
34. Foley, R. C., and K. J. Beh. 1989. Isolation and sequence of sheep IgH and L-chain cDNA. J. Immunol. 142:708.
35. Foley, R. C., and K. J. Beh. 1992. Analysis of immunoglobulin light chain loci in sheep. Anim. Genet. 23:31.
36. Patri, S., and F. Nau. 1992. Isolation and sequence of a cDNA coding for the immunoglobulin μ chain of the sheep. Mol. Immunol. 29:829.
37. H sequences from conventional and heavy antibodies. Mol. Immunol. 34:1121.
38. H segments and their contribution to heavy chain variable region diversity. Immunogenetics 46:283.
39. H locus. EMBO J. 7:727.
40. Malthyssens, G., and T. H. Rabbitts. 1980. Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region. Proc. Natl. Acad. Sci. USA 77:6561.
41. Hein, W. R., and L. Dudler. 1998. Diversity of Ig light chain variable region gene expression in fetal lambs. Int. Immunol. 10:1251.
42. Hood, L. E., W. R. Gray, and W. J. Dreyer. 1996. On the mechanism of antibody synthesis: a species comparison of L-chains. Proc. Natl. Acad. Sci. USA 55:826.
43. Reynaud, C. A., V. Dufour, and J. C. Weill. 1997. Generation of diversity in mammalian gut-associated lymphoid tissues. J. Immunol. 159:3093.
44. H gene repertoire, combinatorial diversification by D gene segments and evolution of the heavy chain locus. EMBO J. 7:739.
45. H chromosomal region. J. Immunol. 140:1651.
46. Tutter, A., and R. Riblet. 1989. Conservation of an immunoglobulin variable-region gene familiy indicates a specific, noncoding function. Proc. Natl. Acad. Sci. USA 86:7460.
47. Saini, S. S., K. Teo, A. Nangpal, B. A. Mallard, and A. Kaushik. 1996. Homologues of murine Vh11 gene are conserved during evolution. Exp. Clin. Immunogenet. 13:154.