Leakage of enteric (Eudragit(®) L)-coated dosage forms in simulated gastric juice in the presence of poly(ethylene glycol)

Journal of Controlled Release

Volumn 67, Issue 1, 2000, Pages 79-88

  Breitkreutz, Jörg ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Coatings; Drug Interaction; Gastric juice resistance; Poly(ethylene glycol); Poly(methacrylic acid)

Indexed keywords

ANTRA MUPS; BISACODYL; EUDRAGIT; MACROGOL; METHYLENE BLUE; OMEPRAZOLE; UNCLASSIFIED DRUG;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DRUG COATING; DRUG INTERACTION; DRUG RELEASE; IN VITRO STUDY; MODEL; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; STOMACH JUICE; TABLET DISINTEGRATION; THEORY;

CALORIMETRY, DIFFERENTIAL SCANNING; COLORING AGENTS; EXCIPIENTS; GASTRIC JUICE; METHYLENE BLUE; MICROSCOPY, ELECTRON, SCANNING; POLYETHYLENE GLYCOLS; POLYMETHACRYLIC ACIDS; SOLUBILITY; TABLETS, ENTERIC-COATED;

EID: 0034659724     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(00)00197-8     Document Type: Article

References (28)

1. Healey J.N.C. Enteric coatings and delayed release. Hardy J.G., Davis S.S., Wilson C.G. Drug Delivery To the Gastrointestinal Tract. 1989;83-96 Ellis Horwood, Chichester, UK.
2. Lehmann K.O.R. Chemistry and application properties of polymethacrylate coating systems. McGinity J.W. Aqueous Polymeric Coatings For Pharmaceutical Dosage Forms. 1989;153-245 Marcel Dekker, New York, NY.
3. Petereit H.-U., Weisbrod W. Formulation and process considerations affecting the stability of solid dosage forms formulated with methacrylate copolymers. Eur. J. Pharm. Biopharm. 47:(1):1999;15-25.
4. Thoma K., Bechthold K. Influence of aqueous coatings on the stability of enteric coated pellets and tablets. Eur. J. Pharm. Biopharm. 47:(1):1999;39-50.
5. K.H. Bauer, K. Lehmann, H.P. Osterwald, G. Rothgang, Überzogene Arzneiformen, Wissenschaftliche Verlagsgesellschaft, D-Stuttgart, 1988.
6. Jenquin M.J., Sarabia R.E., Liebowitz S.M., McGinity J.W. Relationship of film properties to drug release from monolithic films containing adjuvants. J. Pharm. Sci. 81:(10):1992;983-989.
7. Henning D., Kala H. Einsatz von Polyethylenglycol (PEG) zur Steuerung der Permeabilität von Poly(meth)acrylat-überzügen. Pharmazie. 42:(1):1987;26-28.
8. ® RS). Pharmazie. 41:(5):1986;335-338.
9. Ofoefule S.I. Effect of polyethyleneglycol 4000 (PEG 4000) solution on the in vitro release profile of nifedipine from polymer matrices. Biol. Pharm. Bull. 20:(5):1997;574-576.
10. Frömming K.H., Topaloglu Y. Beeinflussung der In vitro- und In vivo-Pharmakonfreisetzung aus einigen Depotformen unter Äthanolbelastung. Arzneim.-Forsch./Drug Res. 25:(12):1975;1958-1964.
11. ®, Norgine GmbH, D-Marburg, German registration number: 37 700,00,00.
12. List P.H., Haun G. Zusammenhang zwischen Lösungsmittel-resten und Permeabilität von Eudragit L-Filmen. Pharm. Ind. 42:(4):1980;399-401.
13. Breitkreutz J. Prediction of intestinal drug absorption properties by three-dimensional solubility parameters. Pharm. Res. 15:(9):1998;1370-1375.
14. Bagley E.B., Nelson T.P., Scigliano J.M. Three-dimensional solubility parameters and their relationship to internal pressure measurements in polar and hydrogen bonding solvents. J. Paint Technol. 43:(1):1971;35-42.
15. Petersen K.-U., Schmutzler W. Protonenpumpenhemmer - Wirkstofffreisetzung aus unterschiedlichen Präparaten. Dtsch. Apoth. Ztg. 139:1999;64-65.
16. Lippold B.H., Lippold B.C. Physikalisch-chemisches Verhalten von Polymethacrylsäurederivaten. Pharm. Ind. 35:1973;854-856.
17. Bodmeier R., Paeratakul O. Leaching of water-soluble plasticizers from polymeric films prepared from aqueous colloidal polymer dispersions. Drug Dev. Ind. Pharm. 18:1992;1865-1882.
18. Hancock B.C., York P., Rowe R.C. The use of solubility parameters in pharmaceutical dosage form design. Int. J. Pharm. 148:1997;1-21.
19. Moldenhauer M.G., Nairn J.G. The control of ethylcellulose microencapsulation using solubility parameters. J. Control. Release. 22:1992;205-218.
20. Rowe R.C. The prediction of compatibility/incompatibility in blends of ethyl cellulose with hydroxypropyl methylcellulose or hydroxypropylcellulose using 2-dimensional solubility parameter maps. J. Pharm. Pharmacol. 38:1986;214-215.
21. Cimmino S., Martuscelli E., Silvestre C. Miscibility prediction based on the corresponding states theory: poly(ethylene oxide)/atactic poly(methyl methacrylate) system. Polymer. 30:1989;393-398.
22. Tiller A.R., Gorella B. Estimation of polymer compatibility from molecular mechanics calculations. Polymer. 35:1994;3251-3259.
23. Pedemonte E., Polleri V., Turturro A., Cimmino S., Silvestre C., Martuscelli E. Thermodynamics of poly(ethylene oxide)-poly(methyl methacrylate) blends: prediction of miscibility based on the corresponding-states theory. Polymer. 35:1994;3278-3281.
24. Voigt R., Leuschner S. Bornschein, Ein Beitrag zur Charakterisierung der Inkompatibilitäten zwischen Arzneistoffen und Polyethylenglykolen sowie ethoxylierten Tensiden. Pharmazie. 37:1982;22-25.
25. J. Breitkreutz, Molecular Modeling-Studien und experimentelle Untersuchungen zur molekularen Struktur von Polyethylenglykolen und zu deren Wechselwirkungen mit Wasser und Phenol, Dissertation (1996), Shaker-Verlag, Aachen, Germany, ISBN 3-8265-1599-4.
26. Jinghua Y., Alfonso G.C., Turturro A., Pedemonte E. Thermodynamics of poly(ethylene oxide)-poly(vinyl acetate)blends. Polymer. 34:1993;1465-1470.
27. Mathur A.M., Hammonds K.F., Klier J., Scranton A.B. Equilibrium swelling of poly(methacrylic acid-g-ethylene glycol) hydrogels: Effect of swelling medium and synthesis conditions. J. Control. Release. 54:1998;177-184.
28. Oyama H.T., Hemker D.J., Frank C.W. Effect of the degree of ionization of poly(methacrylic acid) on the complex formed with pyrene end-labeled poly(ethylene glycol). Macromolecules. 22:1989;1255-1260.