Lipid phase fatty acid flip-flop, is it fast enough for cellular transport?

Journal of Membrane Biology

Volumn 175, Issue 2, 2000, Pages 79-86

  Kleinfeld, A M ^a  

^a TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID;

ADIPOCYTE; CELL TRANSPORT; FATTY ACID TRANSPORT; LIPID BILAYER; MEMBRANE TRANSPORT; REGULATORY MECHANISM; REVIEW;

ANIMALS; BIOLOGICAL TRANSPORT; CELL MEMBRANE; ERYTHROCYTE MEMBRANE; FATTY ACIDS; MEMBRANE LIPIDS;

EID: 0034657978     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002320001056     Document Type: Review

References (59)

1. 1. Abumrad, N.A., El-mmaghrabi, M.R., Amri, E., Lopez, E., Grimaldi, P.A. 1993. Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. J. Biol. Chem. 268:17665-17668
2. 2. Abumrad, N., Harmon, C., Ibrahimi, A. 1998. Membrane transport of long chain fatty acids: evidence for a facilitated process. J. Lipid Res. 39:2309-2318
3. 3. Abumrad, N.A., Perkins, R.C., Park, J.H., Park, C.R. 1981. Mechanism of Long Chain Fatty Acid Permeation in the Isolated Adipocyte. J. Biol. Chem. 256:9183-9191
4. 4. Anel, A., Richieri, G.V., Kleinfeld, A.M. 1993. Membrane partition of fatty acids and inhibition of T cell function. Biochemistry 32:530-536
5. 5. Berk, P.D., Stump, D.D. 1999. Mechanisms of cellular uptake of long chain free fatty acids. Mol. Cell Biochem. 192:17-31
6. 6. Berk, P.D., Wada, H., Horio, Y., Potter, B., Sorrentino, D., Zhou, S.L., Isola, L., Stump, D., Kiang, C.L., Thung, S. 1990. Plasma membrane fatty acid-binding protein and mitochondrial glutamicoxalocetic transaminase of rat liver are related. Proc. Natl. Acad. Sci. USA 87:3484-3488
7. 7. Bojesen, I.N., Bojesen, E. 1996. Specificities of red cell membrane sites transporting three long chain fatty acids. J. Membrane Biol. 149:257-267
8. 8. Broring, K., Haest, C.W.M., Deuticke, B. 1989. Translocation of oleic acid across the erythrocyte membrane. Evidence for a fast process. Biochim. Biophys. Acta 986:321-331
9. 9. Burczynski, F.J., Luxon, B.A. 1994. Is there facilitated uptake of fatty acids by the liver? Interpretation and analysis of experimental data. Can. J. Physiol. Pharmacol. 73:409-420
10. 10. Civelek, V.N., Hamilton, J.A., Tornheim, K., Kelly, K.L., Corkey, B.E. 1996. Intracellular pH in adipocytes: Effects of free fatly acid diffusion across the plasma membrane, lipolytic agonists, and insulin. Proc. Natl. Acad. Sci. 93:10139-10144
11. 11. Cooper, R.B., Noy, N., Zakim, D. 1989. Mechanism for binding of fatty acids to hepatocyte plasma membranes. J. Lipid Res. 30: 1719-1726
12. 12. Daniels, C., Noy, N., Zakim, D. 1985. Rates of Hydration of Fatty Acids Bound to Unilamellar Vesicles of Phosphatidylcholine or to Albumin. Biochemistry 24:3286-3292
13. 13. Doody, M.C., Pownall, H.J., Kao, Y.J., Smith, L.C. 1980. Mechanism and kinetics of transfer of a fluorescent fatty acid between single-walled phosphatidylcholine vesicles. Biochemistry 19:108-116
14. 14. Edidin, M. 1974. Rotational and translational diffusion in membranes. Ann. Rev. Biophys. Bioengin. 9038:180-201
15. 15. Faergeman, N.J., DiRusso, C.C., Elberger, A., Knudsen, J., Black, P.N. 1997. Disruption of the Saccharomyces cerevisiae homologue to the murine fatty acid transport protein impairs uptake and growth on long-chain fatty acids. J. Biol. Chem. 272:8531-8538
16. 16. Fujii, S., Kawaguchi, H., Yasuda, H. 1987. Purification of high affinity fatty acid receptors in rat myocardial sarcolemmal membranes. Lipids 22:544-546
17. 17. Glatz, J.F.C., van der Vusse, G.J. 1996. Cellular fatty acid binding proteins: their function and physiological significance. Prog. Lipid. Res. 35:243-282
18. 18. Glatz, J.F.C., van Nieuwenhoven, F.A., Luiken, J.J.F.P., Schaap, F.G., van der Vusse, G.J. 1997. Role of membrane-associate and cytoplasmic fatty acid-binding proteins in cellular fatty acid metabolism. Prostaglandins Leukotrienes and Essential Fatty Acids 57:373-378
19. 19. Gutknecht, J. 1988. Proton conductance caused by long-chain fatty acids in phospholipid bilayer membranes. J. Membrane Biol. 106:83-93
20. 20. Hamilton, J. 1998. Fatty acid transport: difficult or easy? J. Lipid Res. 39:467-481
21. 21. Hamilton, J.A., Civelek, V.N., Kamp, F., Tornheim, K., Corkey, B.E. 1994. Changes in internal pH caused by movement of fatty acids into and out of clonal pancreatic αcells (HIT). J. Biol. Chem. 269:20852-20856
22. 22. Harmon, C., Luce, P., Abumrad, N. 1992. Labeling of an 88 kDa adipocyte membrane protein by sulpho-N-succinimidyl long-chain fatty acids: inhibition of fatty acid transport. Biochemical Society Transactions 20:811-813
23. 23. Harmon, C.M., Luce, P., Beth, A.H., Abumrad, N.A. 1991. Labeling of adipocyte membranes by sulfo-N-succinimidyl derivatives of long-chain fatty acids: inhibition of fatty acid transport. J. Membrane Biol. 121:261-268
24. 24. Hirsch, D., Stahl, A., Lodish, H.F. 1998. A family of fatty acid transporters conserved from mycobacterium to man. Proc. Natl. Acad. Sci. USA 95:8625-8629
25. 25. Kamp, F., Hamilton, J.A. 1992. pH gradients across phsopholipid membranes caused by fast flip-flop of un-ionized fatty acids. Proc. Natl. Acad. Sci. USA 89:11367-11370
26. 26. Kamp, F., Westerhoff, H.V., Hamilton, J.A. 1993. Movement of fatty acids, fatty acid analogues, and bile acids across phospholipid bilayers. Biochemistry 32:11074-11086
27. 27. Kamp, F., Zakim, D., Zhang, F., Noy, N., Hamilton, J.A. 1995. Fatty acid flip-flop in phospholipid bilayers is extremely fast. Biochemistry 34:11928-11937
28. 28. Kleinfeld, A.M. 1987. Current views of membrane structure. In: Membrane Structure and Function. Vol. 29. R.D. Klausner, C. Kempf, and J. van Renswoude, editors, pp. 1-27. Academic Press, Orlando, FL (Cur. Topics in Membranes and Transport)
29. 29. Kleinfeld, A.M. 1995. Fatty acid transport across membranes. In: Stability and permeability of lipid bilayers. E.A. Disalvo and S. Simon, editors, pp. 241-258. CRC Press, Boca Raton
30. 30. Kleinfeld, A.M., Chu, P., Romero, C. 1997. Transport of long chain native fatty acids across lipid bilayer membranes indicates that transbilayer flip-flop is rate limiting. Biochemistry 36:14146-14158
31. 31. Kleinfeld, A.M., Chu, P., Storch, J. 1997. Flip-flop is slow and rate limiting for the movement of long chain anthroyloxy fatty acids across lipid vesicles. Biochemistry 36:5702-5711
32. 32. Kleinfeld, A.M., Storch, J. 1993. Transfer of long chain fluorescent fatty acids between small and large unilamellar vesicles. Biochemistry 32:2053-2061
33. 33. Kleinfeld, A.M., Storms, S., Watts, M. 1998. Transport of long chain fatty acids across human erthrocyte ghost membranes. Biochemistry 37:8011-8019
34. 34. Kumar, G.B., Black, P.N. 1993. Bacterial long-chain fatty acid transport. J. Biol. Chem. 268:15469-15476
35. 35. Marrink, S.J., Berkowitz, M. 1995. Water and membranes. In: Permeability and Stability of Lipid Bilayers. E.A. Disalvo and S.A. Simon, editors. pp. 21-48. CRC Press, Boca Raton
36. 36. Meddings, J.B., Dietschy, J.M. 1989. A rapid method to assess the hydrophobicity of the intestinal microvillus membrane in vivo. J. Lipid Res. 30:1289-1296
37. 37. Morand, O., Aigrot, S. 1985. Transport of fatty acids across the membrane of human. Biochim. Biophys. Acta 835:68-76
38. 38. Richieri, G.V., Kleinfeld, A.M. 1989. Free fatty acid perturbation of transmembrane signaling in cytotoxic T lymphocytes. J. Immunol. 143:2302-2310
39. 39. Richieri, G.V., Ogata, R.T., Kleinfeld, A.M. 1992. A fluorescently labeled intestinal fatty acid binding protein; Interactions with fatty acids and its use in monitoring free fatty acids. J. Biol. Chem. 267:23495-23501
40. 40. Richieri, G.V., Ogata, R.T., Kleinfeld, A.M. 1996. Kinetics of fatty acid interactions with fatty acid binding proteins from adipocyte, heart, and intestine. J. Biol. Chem. 271:11291-11300
41. 41. Schaffer, J.E., Lodish, H.F. 1994. Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. Cell 79:427-436
42. 42. Schwieterman, W., Sorrentino, D., Potter, B.J., Rand, J., Kiang, C.L., Stump, D., Berk, P.D. 1988. Uptake of oleate by isolated rat adipocytes is mediated by a 40 kDa plasma membrane fatty acid binding protein closely related to that in liver and gut. Proc. Natl. Acad. Sci. USA 85:359-363
43. 43. Seelig, J., Seelig, A. 1980. Lipid conformation in model membranes and biological membranes. Q. Rev. Biophys. 13:19-61
44. 44. Shohet, S.B., Nathan, D.C., Karnovsky, M.L. 1968. Stages in the incorporation of fatty acids into red blood cells. J. Clin. Invest. 47:1096-1108
45. 45. Sorrentino, D., Robinson, R.B., Kiang, C.-L., Berk, P.D. 1989. At physiologic albumin/oleate concentrations oleate uptake by isolated hepatocytes, cardiac myocytes, and adipocytes is a saturable function of the unbound oleate concentration. J. Clin. Invest. 84:1325-1333
46. 46. Sorrentino, D., Stump, D.D., Van Ness, K., Simard, A., Schwab, A.J., Zhou, S.-L., Goresky, C.A., Berk, P.D. 1996. Oleate uptake by isolated hepatocytes and the perfused rat liver is competitively inhibited by palmitate. Am. J. Physiol. 33:G385-G392
47. 47. Srivastava, A., Singh, S., Krishnamoorthy, G. 1995. Rapid transport of protons across membranes by aliphatic amines and acids. J. Phys. Chem. 99:11302-11305
48. 48. Stahl, A., Hirsch, D.J., Gimeno, R.E., Punreddy, S., Ge, P., Watson, N., Patel, S., Kotler, M., Raimondi, A., Tartaglia, L.A., Lodish, H.F. 1999. Identification of the major intestinal fatty acid transport protein. Mol. Cell 4:299-308
49. 49. Stein, W.D. 1986. Transport and Diffusion Across Cell Membranes. Academic Press, Orlando, FL
50. 50. Storch, J., Kleinfeld, A.M. 1986. Transfer of long chain fluorescent free fatty acids between unilamellar vesicles. Biochemistry 25:1717-1726
51. 51. Storch, J., Lechene, C., Kleinfeld, A.M. 1991. Direct determination of free fatty acid transport across the adipocyte plasma membrane using quantitative fluorescence microscopy. J. Biol. Chem. 266: 13473-13476
52. 52. Stremmel, W., Kleinert, H., Fitscher, B., Gunawan, J., Klaassen-Schlüter, C., Möller, K., Wegener, M. 1992. Mechanism of cellurar fatty acid uptake. Biochemical Society Transactions 20:814-817
53. 53. Stuhlsatz-Krouper, S.M., Bennett, N.E., Schaffer, J.E. 1998. Substitution of alanine for serine 250 in the murine fatty acid transport protein inhibits long chain fatty acid transport. J. Biol. Chem. 273:28642-28650
54. 54. Trigatti, B.L., Mangroo, D., Gerber, G.E. 1991. Photoaffinity labeling and fatty acid permeation in 3T3-L1 adipocytes. J. Biol. Chem. 266:22621-22625
55. 55. Unwin, N. 1995. Acetylcholine receptor channel imaged in the open state. Nature 373:37-43
56. 56. Walter, A., Gutknecht, J. 1984. Monocarboxylic acid permeation through lipid bilayer membranes. J. Membrane Biol. 77:255-264
57. 57. Walter, A., Gutknecht, J. 1986. Permeability of small nonelectrolytes through lipid bilayer membranes. J. Membrane Biol. 90:207-217
58. 58. Weiss, T.F. 1996. Cellular Biophysics. First Ed. Vol. 1. MIT Press, Cambridge, MA
59. 59. Zhou, S.L., Stump, D., Sorrentino, D., Potter, B.J., Berk, P.D. 1992. Adipocyte differentiation of 3T3-L1 cells involves augmented expression of a 43-kDa plasma membrane fatty acid-binding protein. J. Biol. Chem. 267:14456-14461