An NMR study of conformations of substituted dipeptides in dodecylphosphocholine micelles: Implications for drug transport

Biopolymers

Volumn 53, Issue 5, 2000, Pages 396-410

  Kloosterman, David A ^a   Goodwin, Jay T ^a   Burton, Philip S ^a   Conradi, Robert A ^a   Stockman, Brian J ^a   Scahill, Terrence A ^a   Blinn, James R ^a  

^a Res Devmt Pharmacia and Upjohn   (United States)

Author keywords

Caco 2 permeability; Dipeptide analogues; Dodecylphosphocholine micelles; Drug transport; Molecular conformation; nmr constraints

Indexed keywords

COMPUTER SIMULATION; CONFORMATIONS; CORRELATION METHODS; MECHANICAL PERMEABILITY; MICELLES; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHARMACODYNAMICS; SIMULATED ANNEALING; SUBSTITUTION REACTIONS;

DIPEPTIDES; DODECYLPHOSPHOCHOLINE; DRUG TRANSPORT;

POLYPEPTIDES;

DIPEPTIDE DERIVATIVE; DRUG; PHOSPHORYLCHOLINE;

ARTICLE; DRUG TRANSPORT; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; MICELLE; MOLECULAR DYNAMICS; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; PROTEIN CONFORMATION;

BIOLOGICAL TRANSPORT, ACTIVE; DIPEPTIDES; MAGNETIC RESONANCE SPECTROSCOPY; MICELLES; MODELS, MOLECULAR; PHOSPHORYLCHOLINE; PROTEIN CONFORMATION; SOLVENTS;

EID: 0034655496     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0282(20000415)53:5<396::AID-BIP4>3.0.CO;2-5     Document Type: Article

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