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Volumn 72, Issue 3, 1998, Pages 2246-2252

Targeting a polyepitope protein incorporating multiple class II- restricted vital epitopes to the secretory/endocytic pathway facilitates immune recognition by CD4+ cytotoxic T lymphocytes: A novel approach to vaccine design

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

EID: 0031911648     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.3.2246-2252.1998     Document Type: Article
Times cited : (61)

References (41)
  • 1
    • 0023099347 scopus 로고
    • Vaccinia virus recombinants expressing the SA11 rotavirus VP7 glycoprotein gene induce serotype-specific neutralizing antibodies
    • Andrew, M. E., D. B. Boyle, B. E. Coupar, P. L. Whitfeld, G. W. Both, and A. R. Bellamy. 1987. Vaccinia virus recombinants expressing the SA11 rotavirus VP7 glycoprotein gene induce serotype-specific neutralizing antibodies. J. Virol. 61:1054-1060.
    • (1987) J. Virol. , vol.61 , pp. 1054-1060
    • Andrew, M.E.1    Boyle, D.B.2    Coupar, B.E.3    Whitfeld, P.L.4    Both, G.W.5    Bellamy, A.R.6
  • 2
    • 0026734563 scopus 로고
    • Formation of complexes between self-peptides and MHC class II molecules in cells defective for presentation of exogenous protein antigens
    • Bikoff, E. K. 1992. Formation of complexes between self-peptides and MHC class II molecules in cells defective for presentation of exogenous protein antigens. J. Immunol. 149:1-8.
    • (1992) J. Immunol. , vol.149 , pp. 1-8
    • Bikoff, E.K.1
  • 3
    • 0011720253 scopus 로고
    • Role for intracellular proteases in the processing and transport of class II HLA antigens
    • Blum, J. S., and P. Cresswell. 1988. Role for intracellular proteases in the processing and transport of class II HLA antigens. Proc. Natl. Acad. Sci. USA 85:3975-3979.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 3975-3979
    • Blum, J.S.1    Cresswell, P.2
  • 4
    • 0021798008 scopus 로고
    • Multiple-cloning-site plasmids for the rapid construction of recombinant poxviruses
    • Boyle, D. B., B. E. Coupar, and G. W. Both. 1985. Multiple-cloning-site plasmids for the rapid construction of recombinant poxviruses. Gene 35:169-177.
    • (1985) Gene , vol.35 , pp. 169-177
    • Boyle, D.B.1    Coupar, B.E.2    Both, G.W.3
  • 6
    • 23444431611 scopus 로고
    • Green fluorescent protein as a marker for gene expression
    • Chalfie, M., Y. Tu, G. Euskirchen, W. W. Ward, and D. C. Prasher. 1994. Green fluorescent protein as a marker for gene expression. Science 263:802-805.
    • (1994) Science , vol.263 , pp. 802-805
    • Chalfie, M.1    Tu, Y.2    Euskirchen, G.3    Ward, W.W.4    Prasher, D.C.5
  • 7
    • 0022871271 scopus 로고
    • Temporal regulation of influenza hemagglutinin expression in vaccinia virus recombinants and effects on the immune response
    • Coupar, B. E., M. E. Andrew, G. W. Both, and D. B. Boyle. 1986. Temporal regulation of influenza hemagglutinin expression in vaccinia virus recombinants and effects on the immune response. Eur. J. Immunol. 16:1479-1487.
    • (1986) Eur. J. Immunol. , vol.16 , pp. 1479-1487
    • Coupar, B.E.1    Andrew, M.E.2    Both, G.W.3    Boyle, D.B.4
  • 8
    • 0028313992 scopus 로고
    • Assembly, transport, and function of MHC class II molecules
    • Cresswell, P. 1994. Assembly, transport, and function of MHC class II molecules. Annu. Rev. Immunol. 12:259-293.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 259-293
    • Cresswell, P.1
  • 9
    • 0030028779 scopus 로고    scopus 로고
    • Invariant chain structure and MHC class II function
    • Cresswell, P. 1996. Invariant chain structure and MHC class II function. Cell 84:505-507.
    • (1996) Cell , vol.84 , pp. 505-507
    • Cresswell, P.1
  • 11
    • 0024374199 scopus 로고
    • Murine cell lines stably expressing the influenza virus hemagglutinin gene introduced by a recombinant retrovirus vector are constitutive targets for MHC class I- and class II-restricted T lymphocytes
    • Eager, K. B., C. J. Hackett, W. U. Gerhard, J. Bennink, L. C. Eisenlohr, J. Yewdell, and R. P. Ricciardi. 1989. Murine cell lines stably expressing the influenza virus hemagglutinin gene introduced by a recombinant retrovirus vector are constitutive targets for MHC class I- and class II-restricted T lymphocytes. J. Immunol. 143:2328-2335.
    • (1989) J. Immunol. , vol.143 , pp. 2328-2335
    • Eager, K.B.1    Hackett, C.J.2    Gerhard, W.U.3    Bennink, J.4    Eisenlohr, L.C.5    Yewdell, J.6    Ricciardi, R.P.7
  • 12
    • 0021962918 scopus 로고
    • Humoral immune response in infectious mononucleosis. Late emergence of anti-EA (R) and the effects of corticosteroid therapy
    • Fleisher, G. R., M. Collins, and S. Fager. 1985. Humoral immune response in infectious mononucleosis. Late emergence of anti-EA (R) and the effects of corticosteroid therapy. J. Adolesc. Health Care 6:424-428.
    • (1985) J. Adolesc. Health Care , vol.6 , pp. 424-428
    • Fleisher, G.R.1    Collins, M.2    Fager, S.3
  • 13
    • 0024238385 scopus 로고
    • Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences
    • Fukuda, M., J. Viitala, J. Matteson, and S. R. Carlsson. 1988. Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences. J. Biol. Chem. 263:18920-18928.
    • (1988) J. Biol. Chem. , vol.263 , pp. 18920-18928
    • Fukuda, M.1    Viitala, J.2    Matteson, J.3    Carlsson, S.R.4
  • 14
    • 0023054680 scopus 로고
    • Immunology. The ins and outs of antigen processing and presentation
    • Germain, R. N. 1986. Immunology. The ins and outs of antigen processing and presentation. Nature 322:687-689.
    • (1986) Nature , vol.322 , pp. 687-689
    • Germain, R.N.1
  • 15
    • 0023818748 scopus 로고
    • Pathogenesis of dengue: Challenges to molecular biology
    • Halstead, S. B. 1988. Pathogenesis of dengue: challenges to molecular biology. Science 239:476-481.
    • (1988) Science , vol.239 , pp. 476-481
    • Halstead, S.B.1
  • 16
    • 0026681729 scopus 로고
    • Localization of Epstein-Barr virus cytotoxic T-cell epilopes using recombinant vaccinia: Implications for vaccine development
    • Khanna, R., S. R. Burrows, M. G. Kurilla, C. A. Jacob, I. S. Misko, T. B. Sculley, E. Kieff, and D. J. Moss. 1992. Localization of Epstein-Barr virus cytotoxic T-cell epilopes using recombinant vaccinia: implications for vaccine development. J. Exp. Med. 176:169-176.
    • (1992) J. Exp. Med. , vol.176 , pp. 169-176
    • Khanna, R.1    Burrows, S.R.2    Kurilla, M.G.3    Jacob, C.A.4    Misko, I.S.5    Sculley, T.B.6    Kieff, E.7    Moss, D.J.8
  • 17
    • 0029095056 scopus 로고
    • Immune regulation in Epstein-Barr virus-associated diseases
    • Khanna, R., S. R. Burrows, and D. J. Moss. 1995. Immune regulation in Epstein-Barr virus-associated diseases. Microbiol. Rev. 59:387-405.
    • (1995) Microbiol. Rev. , vol.59 , pp. 387-405
    • Khanna, R.1    Burrows, S.R.2    Moss, D.J.3
  • 18
    • 0030013725 scopus 로고    scopus 로고
    • Peptide transporter (TAP-1 and TAP-2)-independent endogenous processing of Epstein-Barr virus (EBV) latent membrane protein 2A: Implications for cytotoxic T-lymphocyte control of EBV-associated malignancies
    • Khanna, R., S. R. Borrows, D. J. Moss, and S. L. Silins. 1996. Peptide transporter (TAP-1 and TAP-2)-independent endogenous processing of Epstein-Barr virus (EBV) latent membrane protein 2A: implications for cytotoxic T-lymphocyte control of EBV-associated malignancies. J. Virol. 70: 5357-5362.
    • (1996) J. Virol. , vol.70 , pp. 5357-5362
    • Khanna, R.1    Borrows, S.R.2    Moss, D.J.3    Silins, S.L.4
  • 19
    • 0027173732 scopus 로고
    • EBV peptide epitope sensitization restores human cytotoxic T cell recognition of Burkitt's lymphoma cells. Evidence for a critical role for ICAM-2
    • Khanna, R., S. R. Burrows, A. Suhrbier, C. A. Jacob, H. Griffin, I. S. Misko, T. B. Sculley, M. Rowe, A. B. Rickinson, and D. J. Moss. 1993. EBV peptide epitope sensitization restores human cytotoxic T cell recognition of Burkitt's lymphoma cells. Evidence for a critical role for ICAM-2. J. Immunol. 150: 5154-5162.
    • (1993) J. Immunol. , vol.150 , pp. 154-5162
    • Khanna, R.1    Burrows, S.R.2    Suhrbier, A.3    Jacob, C.A.4    Griffin, H.5    Misko, I.S.6    Sculley, T.B.7    Rowe, M.8    Rickinson, A.B.9    Moss, D.J.10
  • 20
    • 0031569518 scopus 로고    scopus 로고
    • Class I processing defective Burkitt's lymphoma cells are recognised efficiently by CD4+ EBV-specific CTL
    • Khanna, R., S. R. Burrows, S. A. Thomson, D. J. Moss, P. Cresswell, P. Poulsen, and L. Cooper. 1997. Class I processing defective Burkitt's lymphoma cells are recognised efficiently by CD4+ EBV-specific CTL. J. Immunol. 157:3619-3625.
    • (1997) J. Immunol. , vol.157 , pp. 3619-3625
    • Khanna, R.1    Burrows, S.R.2    Thomson, S.A.3    Moss, D.J.4    Cresswell, P.5    Poulsen, P.6    Cooper, L.7
  • 21
    • 0025931944 scopus 로고
    • Expression of Epstein-Barr virus nuclear antigens in anti-IgM-stimulated B cells following recombinant vaccinia infection and their recognition by human cytotoxic T-cells
    • Khanna, R., C. A. Jacob, S. R. Barrows, M. G. Kurilla, E. Kief, I. S. Misko, and D. J. Moss. 1991. Expression of Epstein-Barr virus nuclear antigens in anti-IgM-stimulated B cells following recombinant vaccinia infection and their recognition by human cytotoxic T-cells. Immunology 74:504-510.
    • (1991) Immunology , vol.74 , pp. 504-510
    • Khanna, R.1    Jacob, C.A.2    Barrows, S.R.3    Kurilla, M.G.4    Kief, E.5    Misko, I.S.6    Moss, D.J.7
  • 22
    • 0027304232 scopus 로고
    • Presentation of endogenous viral peptide epitopes by anti-CD40 stimulated human B cells following recombinant vaccinia infection
    • Khanna, R., C. A. Jacob, S. R. Burrows, and D. J. Moss. 1993. Presentation of endogenous viral peptide epitopes by anti-CD40 stimulated human B cells following recombinant vaccinia infection. J. Immunol. Methods 164:41-49.
    • (1993) J. Immunol. Methods , vol.164 , pp. 41-49
    • Khanna, R.1    Jacob, C.A.2    Burrows, S.R.3    Moss, D.J.4
  • 23
    • 0030068375 scopus 로고    scopus 로고
    • Treatment of established tumors with a novel vaccine that enhances major hislocompatibility class II presentation of tumor antigen
    • Lin, K. Y., F. G. Guarnieri, O. F. Staveley, H. I. Levitsky, J. T. August, D. M. Pardoll, and T. C. Wu. 1996. Treatment of established tumors with a novel vaccine that enhances major hislocompatibility class II presentation of tumor antigen. Cancer Res. 56:21-26.
    • (1996) Cancer Res. , vol.56 , pp. 21-26
    • Lin, K.Y.1    Guarnieri, F.G.2    Staveley, O.F.3    Levitsky, H.I.4    August, J.T.5    Pardoll, D.M.6    Wu, T.C.7
  • 24
    • 0023680646 scopus 로고
    • Antigen form influences induction and frequency of influenza-specific class I and class II MHC-restricted cytolytic T lymphocytes
    • Morrison, L. A., V. L. Braciale, and T. J. Braciale. 1988. Antigen form influences induction and frequency of influenza-specific class I and class II MHC-restricted cytolytic T lymphocytes. J. Immunol. 141:363-368.
    • (1988) J. Immunol. , vol.141 , pp. 363-368
    • Morrison, L.A.1    Braciale, V.L.2    Braciale, T.J.3
  • 25
    • 0023928773 scopus 로고
    • Cytotoxic T-cell clones discriminate between A- and B-type Epstein-Barr virus transformants
    • Moss, D. J., I. S. Misko, S. R. Burrows, K. Burman, R. McCarthy, and T. B. Sculley. 1988. Cytotoxic T-cell clones discriminate between A- and B-type Epstein-Barr virus transformants. Nature 331:719-721.
    • (1988) Nature , vol.331 , pp. 719-721
    • Moss, D.J.1    Misko, I.S.2    Burrows, S.R.3    Burman, K.4    McCarthy, R.5    Sculley, T.B.6
  • 26
    • 0025249197 scopus 로고
    • The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route
    • Neefjes, J. J., V. Stollorz, P. J. Peters, H. J. Geuze, and H. L. Ploegh. 1990. The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route. Cell 61:171-183.
    • (1990) Cell , vol.61 , pp. 171-183
    • Neefjes, J.J.1    Stollorz, V.2    Peters, P.J.3    Geuze, H.J.4    Ploegh, H.L.5
  • 27
    • 0025159204 scopus 로고
    • Class II MHC molecules can use the endogenous pathway of antigen presentation
    • Nuchtern, J. G., W. E. Biddison, and R. D. Klausner. 1990. Class II MHC molecules can use the endogenous pathway of antigen presentation. Nature 343:74-76.
    • (1990) Nature , vol.343 , pp. 74-76
    • Nuchtern, J.G.1    Biddison, W.E.2    Klausner, R.D.3
  • 28
    • 0019132427 scopus 로고
    • Multiple mRNA species for the precursor to an adenovirus-encoded glycoprotein: Identification and structure of the signal sequence
    • Persson, H., H. Jornvall, and J. Zabielski. 1980. Multiple mRNA species for the precursor to an adenovirus-encoded glycoprotein: identification and structure of the signal sequence. Proc. Natl. Acad. Sci. USA 77:6349-6353.
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 6349-6353
    • Persson, H.1    Jornvall, H.2    Zabielski, J.3
  • 29
    • 0029156357 scopus 로고
    • GFP in mammalian cells
    • Pines, J. 1995. GFP in mammalian cells. Trends Genet. 11:326-327.
    • (1995) Trends Genet. , vol.11 , pp. 326-327
    • Pines, J.1
  • 30
    • 0029311281 scopus 로고
    • Chimeric green fluorescent protein as a tool for visualizing subcellular organelles in living cells
    • Rizzuto, R., M. Brini, P. Pizzo, M. Murgia, and T. Pozzan. 1995. Chimeric green fluorescent protein as a tool for visualizing subcellular organelles in living cells. Curr. Biol. 5:635-642.
    • (1995) Curr. Biol. , vol.5 , pp. 635-642
    • Rizzuto, R.1    Brini, M.2    Pizzo, P.3    Murgia, M.4    Pozzan, T.5
  • 31
    • 0029151298 scopus 로고
    • Lysosome-associated membrane protein-1-mediated targeting of the HIV-1 envelope protein to an endosomal/lysosomal compartment enhances its presentation to MHC class II-restricted T cells
    • Rowell, J. F., A. L. Ruff, F. G. Guarnieri, O. Staveley, X. Lin, J. Tang, J. T. August, and R. F. Siliciano. 1995. Lysosome-associated membrane protein-1-mediated targeting of the HIV-1 envelope protein to an endosomal/lysosomal compartment enhances its presentation to MHC class II-restricted T cells. J. Immunol. 155:1818-1828.
    • (1995) J. Immunol. , vol.155 , pp. 1818-1828
    • Rowell, J.F.1    Ruff, A.L.2    Guarnieri, F.G.3    Staveley, O.4    Lin, X.5    Tang, J.6    August, J.T.7    Siliciano, R.F.8
  • 32
    • 0029145983 scopus 로고
    • Expression of endogenous peptide-major histocompatibility complex class II complexes derived from invariant chain-antigen fusion proteins
    • Sanderson, S., K. Frauwirth, and N. Shastri. 1995. Expression of endogenous peptide-major histocompatibility complex class II complexes derived from invariant chain-antigen fusion proteins. Proc. Natl. Acad. Sci. USA 92:7217-7221.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7217-7221
    • Sanderson, S.1    Frauwirth, K.2    Shastri, N.3
  • 33
    • 0029620659 scopus 로고
    • The ecology and pathology of Epstein-Barr virus
    • Schmidt, C. W., and I. S. Misko. 1995. The ecology and pathology of Epstein-Barr virus. Immunol. Cell Biol. 73:489-504.
    • (1995) Immunol. Cell Biol. , vol.73 , pp. 489-504
    • Schmidt, C.W.1    Misko, I.S.2
  • 34
    • 0023054136 scopus 로고
    • Alternative splicing and alternative initiation of translation explain the four forms of the Ia antigen-associated invariant chain
    • Strubin, M., C. Berte, and B. Mach. 1986. Alternative splicing and alternative initiation of translation explain the four forms of the Ia antigen-associated invariant chain. EMBO J. 5:3483-3488.
    • (1986) EMBO J. , vol.5 , pp. 3483-3488
    • Strubin, M.1    Berte, C.2    Mach, B.3
  • 35
    • 0024965762 scopus 로고
    • Recognition of pre-processed endogenous antigen by class I but not class II MHC-restricted T cells
    • Sweetser, M. T., L. A. Morrison, V. L. Braciale, and T. J. Braciale. 1989. Recognition of pre-processed endogenous antigen by class I but not class II MHC-restricted T cells. Nature 342:180-182.
    • (1989) Nature , vol.342 , pp. 180-182
    • Sweetser, M.T.1    Morrison, L.A.2    Braciale, V.L.3    Braciale, T.J.4
  • 37
    • 0028998731 scopus 로고
    • Minimal epitopes expressed in a recombinant polyepitope protein are processed and presented to CD8+ cytotoxic T cells: Implications for vaccine design
    • Thomson, S. A., R. Khanna, J. Gardner, S. R. Burrows, B. Coupar, D. J. Moss, and A. Suhrbier. 1995. Minimal epitopes expressed in a recombinant polyepitope protein are processed and presented to CD8+ cytotoxic T cells: implications for vaccine design. Proc. Natl. Acad. Sci. USA 92:5845-5849.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5845-5849
    • Thomson, S.A.1    Khanna, R.2    Gardner, J.3    Burrows, S.R.4    Coupar, B.5    Moss, D.J.6    Suhrbier, A.7
  • 38
    • 0026031205 scopus 로고
    • MHC class II-restricted presentation of intracellular antigen
    • Weiss, S., and B. Bogen. 1991. MHC class II-restricted presentation of intracellular antigen. Cell 64:767-776.
    • (1991) Cell , vol.64 , pp. 767-776
    • Weiss, S.1    Bogen, B.2
  • 39
    • 0029924889 scopus 로고    scopus 로고
    • Recruitment during infectious mononucleosis of CD3+CD4+CD8+ virus-specific cytotoxic T cells which recognise Epstein-Barr virus lytic antigen BHRF1
    • White, C. A., S. M. Cross, M. G. Kurilla, B. M. Kerr, C. Schmidt, I. S. Misko, R, Khanna, and D. J. Moss. 1996. Recruitment during infectious mononucleosis of CD3+CD4+CD8+ virus-specific cytotoxic T cells which recognise Epstein-Barr virus lytic antigen BHRF1. Virology 219:489-492.
    • (1996) Virology , vol.219 , pp. 489-492
    • White, C.A.1    Cross, S.M.2    Kurilla, M.G.3    Kerr, B.M.4    Schmidt, C.5    Misko, I.S.6    Khanna, R.7    Moss, D.J.8
  • 41
    • 0024338401 scopus 로고
    • Brefeldin a specifically inhibits presentation of protein antigens to cytotoxic T lymphocytes
    • Yewdell, J. W., and J. R. Bennink. 1989. Brefeldin A specifically inhibits presentation of protein antigens to cytotoxic T lymphocytes. Science 244: 1072-1075.
    • (1989) Science , vol.244 , pp. 1072-1075
    • Yewdell, J.W.1    Bennink, J.R.2


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