Evidence of deprenyl-insensitive apoptosis of nigral dopamine neurons during development

Developmental Brain Research

Volumn 120, Issue 1, 2000, Pages 95-98

  Groc, Laurent ^a,b,c,d   Levine, Robert A ^a,b,c   Foster, Jane A ^a   Normile, Howard J ^c   Weissmann, Dinah ^d   Bezin, Laurent ^a,d  

^a HENRY FORD HOSPITAL   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c WAYNE STATE UNIVERSITY   (United States)

^d UNIVERSITÉ LYON 1   (France)

Author keywords

Apoptosis; Deprenyl; Substantia nigra

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; SELEGILINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN DEVELOPMENT; BRAIN PROTECTION; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DOSE RESPONSE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEWBORN; NEWBORN PERIOD; NONHUMAN; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA;

ANIMALS; APOPTOSIS; CELL COUNT; DOPAMINE; FEMALE; MONOAMINE OXIDASE; NEURONS; NEUROPROTECTIVE AGENTS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; SELEGILINE; SUBSTANTIA NIGRA;

ANIMALIA; GYMNOMYZA SAMOENSIS;

EID: 0034654544     PISSN: 01653806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-3806(99)00195-9     Document Type: Article

References (19)

1. Ansari K.S., Yu P.H., Kruck T.P.A., Tatton W.G. Rescue of axotomized immature rat facial motoneurons by R(-)-deprenyl: stereospecificity and independence from monoamine oxidase inhibition. J. Neurosci. 13:1993;4042-4053.
2. Butcher S.P., Fairbrother I.S., Kelly J.S., Arbuthnott G.W. Effects of selective monoamine oxidase inhibitors on the in vivo release and metabolism of dopamine in the rat striatum. J. Neurochem. 55:1990;981-988.
3. Cadet J.L., Brannock C. Free radicals and the pathobiology of brain dopamine systems. Neurochem. Int. 32:1998;117-131.
4. Dhingra N.K., Raju T., Meti B.L. Selective reduction of monoamine oxidase A and B in the frontal cortex of subordinate rats. Brain Res. 758:1997;237-240.
5. Finnegan K.T., Skratt J.J., Irwin I., DeLanney L.E., Langston J.W. Protection against DSP-4 induced neurotoxicity by deprenyl is not related to its inhibition of MAO-B. Eur. J. Pharmacol. 184:1990;119-126.
6. Janec E., Burke R.E. Naturally occurring cell death during postnatal development of the substantia nigra pars compacta of rat. Mol. Cell. Neurosci. 4:1993;30-35.
7. Knollema S., Aukema W., Horn H., Korf J., Terhorst G.J. L-Deprenyl reduces brain damage in rats exposed to transient hypoxia-ischemia. Stroke. 26:1995;1883-1887.
8. Kondo T., Sharp F.R., Honkaniemi J., Mikawa S., Epstein C.J., Chan P.H. DNA fragmentation and prolonged expression of c-fos, c-jun, and hsp70 in kainic acid-induced neuronal cell death in transgenic mice overexpressing human CuZn-superoxide dismutase. J. Cereb. Blood Flow Metab. 17(3):1997;241-256.
9. McGeer P.L., Itagaki S., Akiyama H., McGeer E.G. Rate of cell death in parkinsonism indicates active neuropathological process. Ann. Neurol. 24:1988;574-576.
10. Molinengo L., Ghi P. Behavioral and neurochemical effects induced by subchronic L-deprenyl administration. Pharmacol. Biochem. Behav. 58:1997;649-655.
11. Mytilineou C., Cohen G. Deprenyl protects dopaminergic neurons from the neurotoxic effects of 1-methyl-4-phenylpyridinium ion. J. Neurochem. 45:1985;1951-1953.
12. Olanow C.W. Selegiline: current perspectives on issues related to neuroprotection and mortality. Neurology. 47:1996;S210-S216.
13. Oo T.F., Burke R.E. The time course of developmental cell death in phenotypically defined dopaminergic neurons of the substantia nigra. Dev. Brain Res. 98:1997;191-196.
14. Roy E., Bedard P.J. L-Deprenyl increases survival of rat foetal nigral neurones in culture. NeuroReport. 4:1993;1183-1186.
15. Seniuk N.A., Henderson J.T., Tatton W.G., Roder J.C. Increased CNTF gene expression in process-bearing astrocytes following injury is augmented by R(-)-deprenyl. J. Neurosci. Res. 37:1994;278-286.
16. Tatton W.G., Greenwood C.E. Rescue of dying neurons: a new action for deprenyl in MPTP Parkinsonism. J. Neurosci. Res. 30:1991;666-672.
17. Wadia J.S., Chalmers-Redman R.M.E., Ju W.J.H., Carlile G.W., Phillips J.L., Fraser A.D., Tatton W.G. Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: time course and modification by (-)-deprenyl. J. Neurosci. 18:1998;932-947.
18. Wu R.-M., Mohanakumar K.P., Murphy D.L., Chiueh C.C. Antioxidant mechanism and protection of nigral neurons against MPP+ toxicity by deprenyl (Selegeline). Ann. N.Y. Acad. Sci. 738:1994;214-221.
19. Youdim M.B., Collins G.G., Sandler M. Multiple forms of rat brain monoamine oxidase. Nature. 223:1969;626-628.