Protective DNA vaccination against organ-specific autoimmunity is highly specific and discriminates between single amino acid substitutions in the peptide autoantigen

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 4, 2000, Pages 1689-1694

  Weissert, Robert ^a,c   Lobell, Anna ^b   De Graaf, Katrien L ^a,c   Eltayeb, Sana Yousif ^a   Andersson, Roland ^b   Olsson, Tomas ^a   Wigzell, Hans ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; DNA VACCINE; MYELIN BASIC PROTEIN;

AMINO ACID SUBSTITUTION; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; DRUG MECHANISM; GENE TARGETING; IMMUNE RESPONSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; VACCINATION;

ANIMALS; AUTOANTIGENS; CELL DIVISION; DNA; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EPITOPES; IMMUNIZATION; MOLECULAR SEQUENCE DATA; MYELIN BASIC PROTEINS; PEPTIDE FRAGMENTS; RATS; RATS, INBRED LEW; SPLEEN; T-LYMPHOCYTES; VACCINES, DNA;

EID: 0034652209     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.030390097     Document Type: Article

References (19)

1. Waisman, A., Ruiz, P. J., Hirschberg, D. L., Gelman, A., Oksenberg, J. R., Brocke, S., Mor, F., Cohen, I. R. & Steinman, L. (1996) Nat. Med. 2, 899-905.
2. Lobell, A., Weissert, R., Storch, M. K., Svanholm, C., de Graaf, K. L., Lassmann, H., Andersson, R., Olsson, T. & Wigzell, H. (1998) J. Exp. Med. 187, 1543-1548.
3. Donnelly, J. J., Ulmer, J. B., Shiver, J. W. & Liu, M. A. (1997) Annu. Rev. Immunol. 15, 617-648.
4. Hemmer, B., Fleckenstein, B. T., Vergelli, M., Jung, G., McFarland, H., Martin, R. & Wiesmuller, K. H. (1997) J. Exp. Med. 185, 1651-1659.
5. Mason, D. (1998) Immunol. Today 19, 395-404.
6. Wucherpfenning, K. W. & Strominger, J. L. (1995) Cell 80, 695-705.
7. Lehmann, P. V., Forsthuber, T., Miller, A. & Sercarz, E. E. (1992) Nature (London) 358, 155-157.
8. Weissert, R., Svenningsson, A., Lobell, A., de Graaf, K. L., Andersson, R. & Olsson, T. (1998) J. Immunol. 160, 681-690.
9. Mustafa, M., Vingsbo, C., Olsson, T., Issazadeh, S., Ljungdahl, A. & Holmdahl, R. (1994) J. Immunol. 153, 3337-3344.
10. Zhang, J., Medaer, R., Stinissen, P., Hafler, D. & Raus, J. (1993) Science 261, 1451-1454.
11. Lobell, A., Weissert, R., Eltayeb, S., Svanholm, C., Olsson, T. & Wigzell, H. (1999) J. Immunol. 163, 4754-4762.
12. Brocke, S., Gijbels, K., Allegretta, M., Ferber, I., Piercy, C., Blankenstein, T., Martin, R., Utz, U., Karin, N., Mitchell, O., et al. (1996) Nature (London) 379, 343-346.
13. Chen, Y., Inobe, J., Marks, R., Gonnella, P., Kuchroo, V. K. & Weiner, H. L. (1995) Nature (London) 376, 177-180.
14. Javed, N. H., Gienapp, I. E., Cox, K. L. & Whitacre, C. C. (1995) J. Immunol. 155, 1599-1605.
15. Nicholson, L. B., Murtaza, A., Hafler, B. P, Sette, A. & Kuchroo, V. K. (1997) Proc. Natl. Acad. Sci. USA 94, 9279-9284.
16. Maini, M. K., Casorati, G., Dellabona, P., Wack, A. & Beverley, P. C. L. (1999) Immunol. Today 20, 262-266.
17. Gallimore, A., Glithero, A., Godkin, A., Tissot, A. C., Pluckthun, A., Elliot, T., Hengartner, H. & Zinkernagel, R. (1998) J. Exp. Med. 187, 1383-1393.
18. Douillard, P., Pannetier, C., Josien, R., Menoret, S., Kourilsky, P., Soulillou, J. P. & Cuturi, M. C. (1996) J. Immunol. 157, 1250-1260.
19. Ruiz, P. J., Garren, H., Ruiz, I. U., Hirschberg, D. L., Nguyen, L. V., Karpuj, M. V., Cooper, M. T., Mitchell, D. J., Fathman, C. G. & Steinman, L. (1999) J. Immunol. 162, 3336-3341.