Improvement of von Willebrand factor proteolysis after prostacyclin infusion in severe pulmonary arterial hypertension

Circulation

Volumn 102, Issue 20, 2000, Pages 2460-2462

  Veyradier, Agnès ^a,b   Nishikubo, Toshiya ^b   Humbert, Marc ^a   Wolf, Martine ^a,b   Sitbon, Olivier ^a   Simonneau, Gérald ^a   Girma, Jean Pierre ^b   Meyer, Dominique ^a,b  

^a HÔPITAL ANTOINE BÉCLÈRE   (France)

^b INSERM   (France)

Author keywords

Hypertension, pulmonary; Prostaglandins; Proteins; Von Willebrand factor

Indexed keywords

PROSTACYCLIN; PROTEINASE; VON WILLEBRAND FACTOR;

ADULT; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEART INDEX; HEMODYNAMICS; HUMAN; INFUSION; LUNG ARTERY PRESSURE; LUNG VASCULAR RESISTANCE; MALE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PULMONARY HYPERTENSION; REVIEW;

EID: 0034649310     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.102.20.2460     Document Type: Review

References (16)

1. Primary pulmonary hypertension
2. Endothelial dysfunction in primary hypertension
3. Human von Willebrand factor: A multivalent protein composed of identical subunits
4. Von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolyticuremic syndrome
5. Continuous infusion of prostacyclin normalizes plasma markers of endothelial cell injury and platelet aggregation in primary pulmonary hypertension
6. Circulating platelet aggregates indicative of in vivo platelet activation in pulmonary hypertension
7. Abnormal degradation of von Willebrand factor main subunit in pulmonary hypertension
8. Circulating von Willebrand factor antigen as a predictor of short-term prognosis in pulmonary hypertension
9. Laboratory diagnosis of von Willebrand disease
10. Estimation of the von Willebrand factor-cleaving protease in plasma using monoclonal antibodies to vWF
11. Abnormal proteolytic processing of von Willebrand factor Arg611Cys and Arg611His
12. Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura
13. Sialic acid prevents loss of large von Willebrand factor multimers by protecting against amino-terminal proteolytic cleavage
14. Shear stress enhances the proteolysis of von Willebrand factor in normal plasma
15. Decreased sialic acid content of plasma von Willebrand factor in precapillary pulmonary hypertension
16. Continuous infusion of prostacyclin decreases plasma levels of t-PA and PAI-1 in primary pulmonary hypertension