Continuous infusion of prostacyclin normalizes plasma markers of endothelial cell injury and platelet aggregation in primary pulmonary hypertension

Circulation

Volumn 96, Issue 9, 1997, Pages 2782-2784

  Friedman, Ronit ^b   Gregory Mears, J ^a   Barst, Robyn J ^a  

^a Columbia Univ Coll Phys Surgs ^*  (United States)

^b BHN 2 262 ^*

Author keywords

Coagulation; Endothelium derived factors; Platelets; Prostaglandins; Pulmonary heart disease

Indexed keywords

PROSTACYCLIN;

ADOLESCENT; ADULT; ARTICLE; BLOOD CLOTTING; CHILD; CONTINUOUS INFUSION; DRUG EFFECT; HUMAN; HYPERCOAGULABILITY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PULMONARY HYPERTENSION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOSIS; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0342871960     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.96.9.2782     Document Type: Article

References (15)

1. Rubin LJ. Primary pulmonary hypertension. N Engl Med. 1997;336: 111-117.
2. Loyd JE, Atkinson JB, Pietra GG, Virmani R, Newman JH. Heterogeneity of pathologic lesions in familial primary pulmonary hypertension. Am Rev Respir Dis. 1988;138:952-957.
3. Christman BW, McPherson CD, Newman JH, King GA Bernard GR, Groves BM, Loyd JE. An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N Engl J Med. 1992;327:70-75.
4. Barst RJ, Rubin LJ, Long WA, McGoon MD, Rich S, Badesch DB, Groves BM, Tapson VF, Bourge RC, Brundage BH, Koerner SK, Langleben D, Keller CA, Murali S, Uretsky BF, Clayton LM, Jobsis MM, Blackburn SD, Shortino D, Crow JW. A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. N Engl J Med. 1996; 334:296-301.
5. Barst RJ, Rubin LJ, McGoon MD, Caldwell EJ, Long WA, Levy PS. Survival in primary pulmonary hypertension with long-term continuous intravenous prostacyclin. Ann Intern Med. 1994;121: 409-415.
6. Yamaki S, Wagenvoort CA. Comparison of primary plexogenic arteriopathy in adults and children: a morphometric study in 40 patients. Br Heart J. 1985;54:428-434.
7. Barst RJ. Primary pulmonary hypertension in children. In: Rubin LJ, Rich S, ed., Primary Pulmonary Hypertension. (Lung Biology in Health and Disease). New York, NY: Marcel Dekker; 1996: 179-225.
8. Rich S, Dantzker DR, Ayres SM, Bergofsky ED, Brundage BH, Detre KM, Fishman AP, Goldring RM, Groves BM, Koerner SK, Levy PC, Reid LM, Vreim CE, Williams GW. Primary pulmonary hypertension: a national prospective study. Ann Intern Med. 1987; 107:216-223.
9. Lopes AAB, Maeda NY, Aiello VD, Ebaid M, Bydlowki SP. Abnormal multimeric and oligomeric composition is associated with enhanced endothelial expression of von Willebrand factor in pulmonary hypertension. Chest. 1993;104:1455-1460.
10. Rabinovitch M, Andrew M, Thom H, Trusler CA, William WG, Rowe RD, Olley PM. Abnormal endothelial factor VIII associated with pulmonary hypertension, and congenital heart defects. Circulation. 1987;76:1043-1052.
11. Geggel RL, Carvalho CA, Hoyer LW, Reid LM. von Willebrand factor abnormalities in primary pulmonary hypertension. Am Rev Respir Dis. 1987;135:294-299.
12. Kinlough-Rathbone RL, Packham MA, Mustard JF. Vessel injury, platelet adherence and platelet survival. Arteriosclerosis. 1983;3: 529-546.
13. Nowak J, Murray JJ, Oates JA, FitzGerald GA. Biochemical evidence of a chronic activity in platelet and vascular function in healthy individuals who smoke cigarettes. Circulation. 1987;76:6-14.
14. Boyer-Neumann C, Brenot F, Wolf M, Peynaud-Debayle E, Duroux P, Meyere D, Anglé-Camo E, Simonneau G. Continuous infusion of prostacyclin decreases plasma levels of t-PA and PAI-1 in primary pulmonary hypertension. Thromb Haemost. 1995;73: 727-738.
15. Langleben D, Long WA, Barst RJ, Tapson VF, Groves BM, Badesch DB, Bourge RC, Murali S, Ettinger N, Shalit E, Stewart DJ, The North American Primary Pulmonary Hypertension Study Group. Prostacyclin infusion improves the balance between pulmonary clearance and production of endothelin-1 in patients with primary pulmonary hypertension. Circulation. 1995;92(suppl I):I-24. Abstract.