Retroviral vector-mediated transfer of the tumor necrosis factor α gene into human cancer cells restores an apoptotic cell death program and induces a bystander-killing effect

Blood

Volumn 87, Issue 6, 1996, Pages 2486-2495

  Tos, Anna Gillio ^b   Cignetti, Alessandro ^b   Rovera, Giovanni ^b   Foa, Robin ^a  

^a Clinical Section   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; MESSENGER RNA; MONOCLONAL ANTIBODY; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA; VIRUS VECTOR;

APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; CELL GROWTH; CONTROLLED STUDY; DNA CLEAVAGE; GENE TRANSFER; HUMAN; HUMAN CELL; LYMPHOMA CELL LINE; PRIORITY JOURNAL; RETROVIRUS;

EID: 0029979379     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.6.2486.bloodjournal8762486     Document Type: Article

References (53)

1. Old LJ: Tumor necrosis factor (TNF). Science 230:630, 1985
2. Frei E, Spriggs D: Tumor necrosis factor: Still a promising agent. J Clin Oncol 7:291, 1989
3. Ruddle NH: Tumor necrosis factor (TNFα) and lymphotoxin (TNFβ). Curr Opin Immunol 4:327, 1992
4. Palladino MA, Shalaby MR, Kramer SM, Ferraiolo BL, Baughman RA, Deleo AB. Crase D, Marafino B, Aggarwal BB, Figari IS, Liggitt D, Patton JS: Characterization of the antitumor activities of human tumor necrosis factor-α and the comparison with other cytokines: Induction of tumor-specific immunity. J Immunol 138:4023, 1987
5. Philip R, Epstein L: Tumor necrosis factor as immunomodulator and mediator of monocyte toxicity induced by itself, γ-interferon and interieukin-1. Nature 323:86, 1986
6. Shalaby MR, Aggarwal BB, Rinderknecht E, Svedersky LP, Finkle BS, Palladino MA: Activation of human polymorphonuclear neutrophil functions by interferon-γ and tumor necrosis factors. J Immunol 135:2069, 1985
7. Robinet E, Branelec D, Termijtelen AM, Blay JY, Gay F, Chouaib S: Evidence for tumor necrosis factor-α involvement in the optimal induction of class I allospecific cytotoxic T cells. J Immunol 144:788, 1990
8. Ayroldi E, Sorci G, Cannarile L, Riccardi C: Effect of recombinant murine tumor necrosis factor on the generation of natural killer cells in bone marrow cultures. Nat Immun 11:92, 1992
9. Owen-Schaub LB, Gutterman JU, Grimm EA: Synergy of tumor necrosis factor and interleukin-2 in the activation of human cytotoxic lymphocytes: Effect of tumor necrosis factor α and interleukin-2 in the generation of human lymphokine-activated killer cell cytotoxicity. Cancer Res 48:788, 1988
10. Asher AL, Mule JJ, Reichert CM, Shiloni F., Rosenberg SA: Studies of the anti-tumor efficacy of systemically administered recombinant tumor necrosis factor against several murine tumors in vivo. J Immunol 138:963, 1987
11. Rosenberg SA: The immunotherapy and gene therapy of cancer. J Clin Oncol 10:180, 1992
12. Miller AD: Human gene therapy comes of age Nature 357:455, 1992
13. Foa R, Guarini A, Gansbacher B: IL2 treatment for cancer: From biology to gene therapy. Br J Cancer 66:992, 1992
14. Pardoll DM: Cancer vaccines. Immunol Today 14:310, 1993
15. Hernandez-Caselles T, Stutman O: Immune function of tumor necrosis factor. I. Tumor necrosis factor induces apoptosis of mouse thymocytes and can also stimulate or inhibit IL-6-induced proliferation depending on the concentration and mitogenic costimulation. J Immunol 151:3999, 1993
16. Greenblatt MS, Elias L: The type B receptor for tumor necrosis factor-α mediates DNA fragmentation in HL-60 and U937 cells and differentiation in HL-60 cells. Blood 80:1339, 1992
17. Laster SM, Wood JG, Gooding LR: Tumor necrosis factor can induce both apoptotic and necrotic forms of cell lysis. J Immunol 141:2629, 1988
18. Leist M, Gantener F, Bohlinger I, Germann PG, Tiegs G, Wendel A: Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-α requires transcriptional arrest. J Immunol 153:1778, 1994
19. 2+ concentration and DNA fragmentation. Cancer Res 52:1342, 1992
20. Sugarman BJ, Aggarwal BB, Mass PE, Figari IS, Palladino MA Jr, Shepard HM: Recombinant human tumor necrosis factor-α: Effects on proliferation of normal and transformed cells in vitro. Science 230:943, 1985
21. Arione R, Jemma C, Forni M, Marchese C, Benetton G, Giubellino C, Modesti A, Martinotti MG, Cordero di Montezemolo L, Musso T, Forni G: A new childhood T-cell lymphoma established in nude mice and in vitro. Cancer Res 48:1312, 1988
22. Markowitz D, Goff S, Bank A: Construction and use of a safe and efficient amphotropic packaging cell line. Virology 167:400, 1988
23. Cuturi MC, Murphy M, Costa-Giomi MP, Weinmann R, Perussia B, Trinchieri G: Independent regulation of tumor necrosis factor and lymphotoxin production by human peripheral blood lymphocytes. J Exp Med 165:1581, 1987
24. Brockhaus M, Schoenfeld HJ, Schlaeger EJ, Hunziker W, Lesslauer W, Loetscher H: Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies. Proc Natl Acad Sci USA 87:3127, 1990
25. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C: A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 139:271, 1991
26. Pennica D, Nedwin GE, Hayflick JS, Seeburg PH, Derynck R, Palladino MA, Kohr WJ, Aggarwal BB, Goeddel DV: Human tumor necrosis factor: Precursor structure, expression and homology to lymphotoxin. Nature 312:724, 1984
27. McKnight SL, Gavis ER: Expression of the herpes thymidine kinase gene in Xoenopus laevis oocytes: An assay for the study of deletion mutants constructed in vitro. Nucleic Acids Res 8:5849, 1980
28. Hantzopoulos PA, Sullenger BA, Ungers G, Gilboa E: Improved gene expression upon transfer of the adenosine deaminase minigene outside the transcriptional unit of a retroviral vector. Proc Natl Acad Sci USA 86:3519, 1989
29. Feigner PL, Ringold GM: Cationic liposome-mediated transfection. Nature 337:387, 1989
30. Markowitz D, Goff S, Bank A: A safe packaging line for gene transfer: Separating viral genes on two different plasmids. J Virol 62:1120, 1988
31. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156, 1987
32. Flick DA, Gifford GE: Comparison of in vitro cell cytotoxic assays for tumor necrosis factor. J Immunol Methods 68:167, 1984
33. Vaux DL: Toward an understanding of the molecular mechanisms of physiological cell death. Proc Natl Acad Sci USA 90:786, 1993
34. Reed CJ: Bcl-2 and the regulation of programmed cell death. J Cell Biol 124:1, 1994
35. Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:34, 1990
36. Barinaga M: Cell suicide: By ICE, not fire. Science 263:754, 1994
37. Oltvai ZN, Milliman CL, Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell 74:609, 1993
38. Culotta E, Koshland DE Jr: p53 sweeps through cancer research. Science 262:1958, 1993
39. Nigro JM, Baker SJ, Preisinger AC, Jessup JM, Hostetter R, Cleary K, Bigner SH, Davidson N, Baylin S, Devilee P, Glover T, Collins FS, Weston A, Modall R, Harris CC, Vogelstein B: Mutations in the p53 gene occur in diverse human tumour types. Nature 342:705, 1989
40. Schiller JH, Witt PL, Storer B, Alberti D, Tombes MB, Arzoomanian R, Brown RR, Proctor RA, Voss SD, Spriggs DR, Trump DL, Borden EC: Clinical and biological effects of combination therapy with γ-interferon and tumor necrosis factor. Cancer 69:562, 1992
41. Urba WJ, Kopp WC, Clark JW, Smith JW II, Steis RG, Huber C, Coggin D, Longo DL: The in vivo immunomodulatory effect of recombinant interferon γ plus recombinant tumor necrosis factor. J Clin Oncol 9:1831, 1991
42. Bergamaschi G, Carlo-Stella C, Cazzola M, De Fazio P, Peverali FA, Della Valle G: Tumor necrosis factor α down-regulates c-myc mRNA expression and induces in vitro monocytic differentiation in fresh blast cells from patients with acute myelogenous leukemia. Leukemia 4:426, 1990
43. Koo AS, Chiu R, Soong J, Dekernion JB, Belldegrun A: The expression of C-jun and junB mRNA in renal cell cancer and in vitro regulation by transforming growth factor β1 and tumor necrosis factor α1. J Urol 148:1314, 1992
44. Manchester KM, Heston WD, Donner DB: Tumor necrosis factor-induced cytotoxicity is accompanied by intracellular mitogenic signals in ME-180 human cervical carcinoma cells. Biochem J 290:185, 1993
45. + cells via p55 TNFα receptors. Blood 84:2506, 1994
46. Janicke RU, Lee FH, Porter AG: Nuclear c-myc plays an important role in the cytotoxicity of tumor necrosis factor α in tumor cells. Mol Cell Biol 14:5661, 1994
47. Anderson WF. Gene therapy of cancer. Hum Gene Ther 5.1, 1994
48. Colombo MP, Forni G: Cytokine gene transfer in tumor inhibition and tumor therapy: Where are we now? Immunol Today 15:48, 1994
49. Blankenstein T, Qin Z, Uberla K, Muller W, Rosen H, Volk HD, Diamantstein T: Tumor suppression after tumor cell-targeted tumor necrosis factor α gene transfer. J Exp Med 173:1047, 1991
50. Asher AL, Mule' JJ, Kasid A, Restifo NP, Salo JC, Reichert CM, Jaffe G, Fendly B, Kriegler M, Rosenberg SA: Murine tumor cells transduced with the gene for tumor necrosis factor-α. Evidence for paracrine immune effects of tumor necrosis factor against tumors. J Immunol 146:3227, 1991
51. Allione A, Consalvo M, Nanni P, Lollini PL, Cavallo F, Giovarelli M, Forni M, Gullno A, Colombo MP, Dellabona P, Hock H, Blankenstein T, Rosenthal FM, Gansbacher B, Bosco MC, Musso T, Gusella L, Forni G: Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin (IL)-2, IL-4, IL-6, IL-7, IL-10, tumor necrosis factor α, granulocyte-macrophage colony-stimulating factor, and γ-interferon or admixed with conventional adjuvants. Cancer Res 54:6022, 1994
52. Cignetti A, Guarini A, Carbone A, Forni M, Cronin K, Forni G, Gansbacher B, Foa R: Transduction of the IL2 gene into human acute leukemia cells: Induction of tumor rejection without modifying cell proliferation and IL2 receptor expression. J Natl Cancer Inst 86:785, 1994
53. Novelli F, Di Pierro F, Francia di Celle P, Bertini S, Affaticati P, Garotta G, Forni G: Environmental signals influencing expression of the IFN-γ receptor on human T cells control whether IFN-γ promotes proliferation or apoptosis. J Immunol 152:496, 1994