Methyl DNA adducts, DNA repair, and hypoxanthine-guanine phosphoribosyl transferase mutations in peripheral white blood cells from patients with malignant melanoma treated with dacarbazine and hydroxyurea

Clinical Cancer Research

Volumn 2, Issue 2, 1996, Pages 303-310

  Philip, Philip A ^a,e   Souliotis, Vassilis L ^b   Harris, Adrian L ^a   Salisbury, Amanda ^a   Tates, Ad D ^c   Mitchell, Karen ^a   Van Delft, Joost H M ^d   Ganesan, Trivadi S ^a   Kyrtopoulos, Soterios A ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b INSTITUTE OF BIOLOGY   (Greece)

^c LEIDEN UNIVERSITY   (Netherlands)

^d TNO   (Netherlands)

^e WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DACARBAZINE; HYDROXYUREA; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DNA ADDUCT; DNA REPAIR; FEMALE; GENE MUTATION; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LEUKOCYTE; MALE; MELANOMA; PRIORITY JOURNAL;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DACARBAZINE; DNA ADDUCTS; DNA REPAIR; FEMALE; GUANINE; HUMANS; HYDROXYUREA; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LEUKOCYTES; MALE; MELANOMA; MIDDLE AGED; MUTATION; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE;

EID: 0029995092     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Meer, L., Janzer, R. C., Kleihues, P., and Kolar, G. F. In vivo metabolism and reaction with DNA of the cytostatic agent 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC). Biochem. Pharmacol., 35: 3243-3247, 1986.
2. Mizuno, N. S., and Decker, R W Alteration of DNA by 5-(3-methyl-1-triazeno)imidazole-4-carboxamide (NSC-407347). Biochem. Pharmacol., 25: 2643-2647, 1976.
3. Saffhill, R., Margison, G. P., and O'Connor, P. J. Mechanisms of carcinogenesis induced by alkylating agents. Biochim. Biophys. Acta, 823: 111-145, 1985.
4. 6-methylguanine synthesised at the rat H-ras N-methyl-N-nitro-sourea activation site and introduced into Escherichia coli. Carcinogenesis, 10, 373-377, 1989.
5. - phenotypes by a series of alkyltriazenylimidazoles. Carcinogenesis, 7: 259-265, 1986.
6. 6-methylguanine in human leucocyte DNA after intravenous exposure to dacarbazine. Carcinogenesis, 12: 285-288, 1991.
7. 6-alkylguanine. FASEB J., 6: 2302-2310, 1992.
8. Maynard, K., Parsons, P. G., Cerny, T., and Margison, G. P Relationships among cell survival, O-alkylguanine-DNA alkyltransferase activity and reaction of methylated adenovirus 5 and herpes simplex virus type 1 in human melanoma cell lines. Cancer Res., 49: 4813-4817, 1989.
9. 6-alkylguanine-DNA alkyltransferase and sensitivity to procarbazine in human brain-tumor xenografts. J. Neurosurg., 70: 573-577, 1989.
10. 6-methylguanine-DNA methyltransferase. Proc. Am. Assoc. Cancer Res., 34: 356, 1993.
11. 6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res., 50: 6119-6129, 1990.
12. 6-alkylguanine DNA-alkyltransferase in human liver and melanoma. Br. J. Cancer, 66: 355-360, 1992.
13. 6-alkylguanine-DNA alkyltransferase in human peripheral blood mononuclear cells Br. J. Cancer, 67: 216-221, 1993.
14. 6-methyldeoxyguanosine in human leucocyte DNA following sequential DTIC and fotemustine chemotherapy. Br. J. Cancer, 69: 853-857, 1994.
15. van Delft, J. H. M., van den Ende, A. M. C., Keizer, H. J., Ouwerkerk, J., and Baan, R. A. Determination of N7-methylguanine in DNA of white blood cells from cancer patients treated with dacarbazine. Carcinogenesis, 13: 1257-1259, 1992.
16. 6-alkylguanines or 1-alkyladenines. Proc. Natl. Acad. Sci. USA, 78: 856-860, 1981.
17. O'Connor, T. R., and Laval, J. Human cDNA expressing a functional DNA glycosylase excising 3-methyladenine and 7-methylguanine. Biochem. Biophys. Res. Commun., 176: 1170-1177, 1991.
18. Snyder, R. D. Inhibitors of ribonucleotide reductase alter DNA repair in human fibroblasts through specific depletion of purine deoxynucleotide triphosphates. Cell Biol. Toxicol., 1: 81-94, 1984.
19. Philip, P. A., Kaklamanis, L., Carmichael, J., Tonkin, K., Morrison, H., Gatter, K., Harris, A. L. The influence of high dose hydroxyurea on the incorporation of 5-iodo-2-deoxyuridine (IUdR) by human bone marrow and tumour cells in vivo. Br. J. Cancer, 67: 644-649, 1984.
20. 6-alkylguanine-DNA-alkyltransferase based on the use of an oligonucleotide substrate, and its application to the measurement of DNA repair activity in extracts of biopsy samples of human urinary bladder mucosa. Carcinogenesis, 10: 1203-1208, 1989.
21. 6-methylguanine in human blood leucocyte DNA during exposure to procarbazine and its relationships with dose and repair. Cancer Res., 50: 2759-2764, 1990.
22. 6-methylguanine. Cancer Res., 49: 6997-7001, 1989.
23. van Delft, J. H. M., van Winden, M. J. M., Luiten-Schuite, A., Ribeiro, L R., and Baan, R. A. Comparison of various immunochemical assays for the detection of N7-(2-hydroxyethyl)guanine in DNA with monoclonal antibodies that are raised against imidazole N7-(2-hydroxyethyl)guanosine. Carcinogenesis, 115: 1967-1973, 1994.
24. van Delft, J. H. M., van Weert, E. J. M., Schellekens, M. M., Claassen, E., and Baan, R. A. The isolation of monoclonal antibodies selected for the detection of imidazole ring-open N7-ethylguanine in purified DNA and in cells in situ. Crossreaction with methyl, 2-hydroxyethyl and sulphur mustard adducts. Carcinogenesis, 12: 1041-1049, 1991.
25. Tates, A. D., van Dam, F. J., van Mossel, H., Schoemaker, H., Thijssen, J. C. P., Woldring, V. M., Zwinderman, A. H., and Natarajan, A. T. Use of the clonal assay for the measurement of frequencies of HPRT mutants in T-lymphocytes from five control populations. Mutat. Res., 253: 199-213, 1991.
26. Tates, A. D., Grummt, T., Törnqvist, M., Farmer, P. B., van Dam, F. J., van Mossel, H., Shoemaker, H. M., Osterman-Golkar, S., Uebel, Ch., Tang, Y. S., Zwinderman, A. H., Natarajan, A. T., and Ehrenberg, L. Biological and chemical monitoring of occupational exposure to ethylene oxide. Mutat. Res., 250: 483-497, 1991.
27. Tates, A. D., van Dam, F. J., Natarajan, A. T., Zwinderman, A. H., and Osanto, S. Frequencies of HPRT mutants and micronuclei in lymphocytes of cancer patients under chemotherapy: a prospective study. Mutat. Res., 307: 293-306, 1994.
28. Nathanson, L., Wolter, J., Horton, J., Colsky, J., Shnider, B. I., and Schilling, A. Characteristics of prognosis and response to an imidazole carboxamide in malignant melanoma. Clin. Pharmacol. Ther., 12: 955-960, 1971.
29. 6-alkylguanine-DNA alkyltransferase activities in gastric mucosa and circulating lymphocytes. Carcinogenesis, 11: 431-436, 1990.
30. 6-methylguanine in humans and rodents treated with procarbazine. Carcinogenesis, 15: 1675-1680, 1994.
31. 6-alkylguanine-DNA alkyltransferase in human after nitrosourea exposure. Cancer Res., 48: 5368-5373, 1988.
32. 6-alkylguanine synthesis in hone marrow hematopoietic precursors. Cancer Res., 47: 89-95, 1987.
33. Park, J-W., and Ames, B. N. 7-methylguanine adducts in DNA are normally present at high levels and increase on aging: analysis by HPLC with electrochemical detection. Proc. Natl. Acad. Sci. USA, 85: 7467-7470, 1988.
34. Walles, S. A. S., and Ringborg, U. Induction and time course of DNA single-strand breaks in lymphocytes from patients treated with dacarbazine. Carcinogenesis, 12: 1153-1154, 1991.
35. Dehazya, P., and Sirover, M. A. Regulation of hypoxanthine DNA glycosylase in normal human and Bloom's syndrome fibroblasts. Cancer Res., 46: 3756-3761, 1986.
36. Cool, B., and Sirover, M. A. Proliferation-dependent regulation of DNA glycosylases in progeroid cells. Mutat. Res., 237: 211-220, 1990.
37. Al-Hawary, B. A., and Al-Saleh, A. A. Cytogenetic effects of dacarbazine on mouse bone marrow cells in vivo. Mutat. Res., 223: 259-266, 1989.