메뉴 건너뛰기




Volumn 24, Issue 1-2, 1999, Pages 43-56

Antisense oligonucleotide blockade of connexin expression during embryonic bone formation: Evidence of functional compensation within a multigene family

Author keywords

Antisense oligonucleotide blockade; Bone; Chick embryo; Connexin 43 (Gj 1); Connexin 45 (Gj 6); Craniofacial; Functional compensation; Gap junctions; Mesenchyme; Organ culture

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; GAP JUNCTION PROTEIN;

EID: 0033011398     PISSN: 0192253X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1520-6408(1999)24:1/2<43::aid-dvg6>3.0.co;2-b     Document Type: Article
Times cited : (31)

References (59)
  • 1
    • 0027752316 scopus 로고
    • Antisense attenuation of Wnt-1 and Wnt-3a expression in whole embryo culture reveals roles for these genes in craniofacial, spinal cord, and cardiac morphogenesis
    • Augustine KA, Liu ET, Sadler TW. 1993. Antisense attenuation of Wnt-1 and Wnt-3a expression in whole embryo culture reveals roles for these genes in craniofacial, spinal cord, and cardiac morphogenesis. Dev Genet 14:500-520.
    • (1993) Dev Genet , vol.14 , pp. 500-520
    • Augustine, K.A.1    Liu, E.T.2    Sadler, T.W.3
  • 2
    • 0025108761 scopus 로고
    • Molecular cloning and developmental expression of two chick embryo gap junction proteins
    • Beyer EC. 1990. Molecular cloning and developmental expression of two chick embryo gap junction proteins. J Biol Chem 265:14439-14443.
    • (1990) J Biol Chem , vol.265 , pp. 14439-14443
    • Beyer, E.C.1
  • 3
    • 0027254716 scopus 로고
    • Gap junctions
    • Beyer EC. 1993. Gap junctions. Int Rev Cytol 137C:1-37.
    • (1993) Int Rev Cytol , vol.137 C , pp. 1-37
    • Beyer, E.C.1
  • 4
    • 0023551497 scopus 로고
    • Connexin 43, a protein from rat heart homologous to a gap junction protein from liver
    • Beyer EC, Paul DL, Goodenough DA. 1987. Connexin 43, a protein from rat heart homologous to a gap junction protein from liver. J Cell Biol 105:2621-2629.
    • (1987) J Cell Biol , vol.105 , pp. 2621-2629
    • Beyer, E.C.1    Paul, D.L.2    Goodenough, D.A.3
  • 5
    • 0002283285 scopus 로고
    • The connexins, a family of related gap junction proteins
    • Hertzberg EL, Johnson RG, editors. New York: Alan R. Liss
    • Beyer EC, Goodenough DA, Paul DL. 1988. The connexins, a family of related gap junction proteins. In: Hertzberg EL, Johnson RG, editors. Gap junctions. New York: Alan R. Liss, pp 167-175.
    • (1988) Gap Junctions , pp. 167-175
    • Beyer, E.C.1    Goodenough, D.A.2    Paul, D.L.3
  • 6
    • 0023696285 scopus 로고
    • Ultrastructural analysis of bone nodules formed in vitro by isolated fetal rat calvarial cells
    • Bhargava U, Bar-lev M, Bellows CG, Aubin JE. 1988. Ultrastructural analysis of bone nodules formed in vitro by isolated fetal rat calvarial cells. Bone 9:155-163.
    • (1988) Bone , vol.9 , pp. 155-163
    • Bhargava, U.1    Bar-Lev, M.2    Bellows, C.G.3    Aubin, J.E.4
  • 7
    • 0030250207 scopus 로고    scopus 로고
    • The cellular Internet: On-line with connexins
    • Bruzzone R, White TW, Goodenough DA. 1996a. The cellular Internet: On-line with connexins. Bioessays 18:709-718.
    • (1996) Bioessays , vol.18 , pp. 709-718
    • Bruzzone, R.1    White, T.W.2    Goodenough, D.A.3
  • 8
    • 0029974655 scopus 로고    scopus 로고
    • Connections with connexins: The molecular basis of direct intercellular signalling
    • Bruzzone R, White TW, Paul DL. 1996b. Connections with connexins: The molecular basis of direct intercellular signalling. Eur J Biochem 238:1-27.
    • (1996) Eur J Biochem , vol.238 , pp. 1-27
    • Bruzzone, R.1    White, T.W.2    Paul, D.L.3
  • 9
    • 0028618619 scopus 로고
    • Design and application of antisense oligonucleotides in cell culture, in vivo, and as therapeutic agents
    • Brysch W, Schlingensiepen K-H. 1994. Design and application of antisense oligonucleotides in cell culture, in vivo, and as therapeutic agents. Cell Mol Neurobiol 14:557-568.
    • (1994) Cell Mol Neurobiol , vol.14 , pp. 557-568
    • Brysch, W.1    Schlingensiepen, K.-H.2
  • 11
    • 0025131814 scopus 로고
    • Antisense strategies in cell and developmental biology
    • Colman A. 1990. Antisense strategies in cell and developmental biology. J Cell Sci 97:399-409.
    • (1990) J Cell Sci , vol.97 , pp. 399-409
    • Colman, A.1
  • 12
    • 0030000245 scopus 로고    scopus 로고
    • Progress in antisense oligonucleotide therapeutics
    • Crooke ST, Bennett CF. 1996. Progress in antisense oligonucleotide therapeutics. Annu Rev Pharmacol Toxicol 36:107-129.
    • (1996) Annu Rev Pharmacol Toxicol , vol.36 , pp. 107-129
    • Crooke, S.T.1    Bennett, C.F.2
  • 13
    • 0030025898 scopus 로고    scopus 로고
    • Expression of the gap junction proteins connexin31 and connexin43 correlates with communication compartments in extra-embryonic tissues and in the gastrulating mouse embryo, respectively
    • Dahl E, Winterhager E, Reuss B, Traub O, Butterweck A, Willecke K. 1996. Expression of the gap junction proteins connexin31 and connexin43 correlates with communication compartments in extra-embryonic tissues and in the gastrulating mouse embryo, respectively. J Cell Sci 109:191-197.
    • (1996) J Cell Sci , vol.109 , pp. 191-197
    • Dahl, E.1    Winterhager, E.2    Reuss, B.3    Traub, O.4    Butterweck, A.5    Willecke, K.6
  • 14
    • 0029883925 scopus 로고    scopus 로고
    • Multiple members of the connexin gene family participate in preimplantation development of the mouse
    • Davies TC, Barr KJ, Jones DH, Zhu D, Kidder GM. 1996. Multiple members of the connexin gene family participate in preimplantation development of the mouse. Dev Genet 18:234-243.
    • (1996) Dev Genet , vol.18 , pp. 234-243
    • Davies, T.C.1    Barr, K.J.2    Jones, D.H.3    Zhu, D.4    Kidder, G.M.5
  • 17
    • 0019774348 scopus 로고
    • Morphological evidence of gap junctions between bone cells
    • Doty SB. 1981. Morphological evidence of gap junctions between bone cells. Calcif Tissue Int 33:509-512.
    • (1981) Calcif Tissue Int , vol.33 , pp. 509-512
    • Doty, S.B.1
  • 18
    • 0006289642 scopus 로고
    • Cell-to-cell communication in bone tissue
    • Davidovitch Z, editor. Birmingham, AL: EBSCO Media
    • Doty SB. 1988. Cell-to-cell communication in bone tissue. In: Davidovitch Z, editor. The biological mechanisms of tooth eruption and root resorption. Birmingham, AL: EBSCO Media, pp 61-69.
    • (1988) The Biological Mechanisms of Tooth Eruption and Root Resorption , pp. 61-69
    • Doty, S.B.1
  • 19
    • 0030002099 scopus 로고    scopus 로고
    • Topographically induced bone formation in vitro: Implications for bone implants and bone grafts
    • Gray C, Boyde A, Jones SJ. 1996. Topographically induced bone formation in vitro: Implications for bone implants and bone grafts. Bone 18:115-123.
    • (1996) Bone , vol.18 , pp. 115-123
    • Gray, C.1    Boyde, A.2    Jones, S.J.3
  • 20
    • 84924926133 scopus 로고
    • A series of normal stages in the development of the chick embryo
    • Hamburger V, Hamilton H. 1951. A series of normal stages in the development of the chick embryo. J Morphol 88:49-92.
    • (1951) J Morphol , vol.88 , pp. 49-92
    • Hamburger, V.1    Hamilton, H.2
  • 21
    • 0018389973 scopus 로고
    • Cell-to-cell communication of osteoblasts
    • Jeasonne BG. 1979. Cell-to-cell communication of osteoblasts. J Dent Res 57:1415-1423.
    • (1979) J Dent Res , vol.57 , pp. 1415-1423
    • Jeasonne, B.G.1
  • 23
    • 0027512851 scopus 로고
    • Uptake and efficacy of phosphodiester and modified antisense oligonucleotides in primary cell cultures
    • Krieg AM. 1993. Uptake and efficacy of phosphodiester and modified antisense oligonucleotides in primary cell cultures. Clin Chem 39:710-712.
    • (1993) Clin Chem , vol.39 , pp. 710-712
    • Krieg, A.M.1
  • 24
    • 0026813055 scopus 로고
    • Molecular biology and genetics of gap junction channels
    • Kumar N, Gilula NB. 1992. Molecular biology and genetics of gap junction channels. Semin Cell Biol 3:3-16.
    • (1992) Semin Cell Biol , vol.3 , pp. 3-16
    • Kumar, N.1    Gilula, N.B.2
  • 25
    • 0030028301 scopus 로고    scopus 로고
    • The gap junction communication channel
    • Kumar NM, Gilula NB. 1996. The gap junction communication channel. Cell 84:381-388.
    • (1996) Cell , vol.84 , pp. 381-388
    • Kumar, N.M.1    Gilula, N.B.2
  • 26
    • 0029742875 scopus 로고    scopus 로고
    • The role of gap junction membrane channels in development
    • Lo CW. 1996. The role of gap junction membrane channels in development. J Bioenerg Biomembr 28:379-385.
    • (1996) J Bioenerg Biomembr , vol.28 , pp. 379-385
    • Lo, C.W.1
  • 27
    • 0029960225 scopus 로고    scopus 로고
    • Constitutive in vivo mRNA expression by osteocytes of beta-actin, osteocalcin, connexin-43, IGF-I, c-fos and c-jun, but not TNF-alpha nor tartrate-resistant acid phosphatase
    • Mason DJ, Hillam RA, Skerry TM. 1996. Constitutive in vivo mRNA expression by osteocytes of beta-actin, osteocalcin, connexin-43, IGF-I, c-fos and c-jun, but not TNF-alpha nor tartrate-resistant acid phosphatase. J Bone Miner Res 11:350-357.
    • (1996) J Bone Miner Res , vol.11 , pp. 350-357
    • Mason, D.J.1    Hillam, R.A.2    Skerry, T.M.3
  • 29
    • 0027968667 scopus 로고
    • Gap junction proteins exhibit early and specific expression during intramembranous bone formation in the developing chick mandible
    • Minkoff R, Rundus VR, Parker SB, Hertzberg EL, Laing JG, Beyer EC. 1994. Gap junction proteins exhibit early and specific expression during intramembranous bone formation in the developing chick mandible. Anat Embryol 190:231-241.
    • (1994) Anat Embryol , vol.190 , pp. 231-241
    • Minkoff, R.1    Rundus, V.R.2    Parker, S.B.3    Hertzberg, E.L.4    Laing, J.G.5    Beyer, E.C.6
  • 30
    • 0345106104 scopus 로고    scopus 로고
    • Craniofacial development in fetal mice lacking connexin43
    • Minkoff R, Bales ES, Beyer EC, Guerrero P. 1996. Craniofacial development in fetal mice lacking connexin43. J Dent Res 75:225.
    • (1996) J Dent Res , vol.75 , pp. 225
    • Minkoff, R.1    Bales, E.S.2    Beyer, E.C.3    Guerrero, P.4
  • 31
    • 0344243845 scopus 로고    scopus 로고
    • Antisense oligonucleotide blockade of connexin expression during embryonic bone formation
    • Minkoff R, Bales ES, Kerr CA. 1997a. Antisense oligonucleotide blockade of connexin expression during embryonic bone formation. J Dent Res 76:368.
    • (1997) J Dent Res , vol.76 , pp. 368
    • Minkoff, R.1    Bales, E.S.2    Kerr, C.A.3
  • 32
    • 0030912262 scopus 로고    scopus 로고
    • Expression patterns of connexin43 protein during facial development in the chick embryo: Association with outgrowth, attachment, and closure of the midfacial primordia
    • Minkoff R, Parker SB, Rundus VR, Hertzberg EL. 1997b. Expression patterns of connexin43 protein during facial development in the chick embryo: Association with outgrowth, attachment, and closure of the midfacial primordia. Anat Rec 248:279-290.
    • (1997) Anat Rec , vol.248 , pp. 279-290
    • Minkoff, R.1    Parker, S.B.2    Rundus, V.R.3    Hertzberg, E.L.4
  • 33
    • 0345537568 scopus 로고    scopus 로고
    • Immunohistochemistry of connexin expression in bone following antisense oligodeoxynucleotide blockade
    • Minkoff R, Bales ES, Struss WE. 1998. Immunohistochemistry of connexin expression in bone following antisense oligodeoxynucleotide blockade. J Dent Res 77B:883.
    • (1998) J Dent Res , vol.77 B , pp. 883
    • Minkoff, R.1    Bales, E.S.2    Struss, W.E.3
  • 34
    • 0025287594 scopus 로고
    • Expression of the gap junction protein connexin43 in embryonic chick lens: Molecular cloning, ultrastructural localization, and post-translational phosphorylation
    • Musil LS, Beyer EC, Goodenough DA. 1990. Expression of the gap junction protein connexin43 in embryonic chick lens: Molecular cloning, ultrastructural localization, and post-translational phosphorylation. J Membr Biol 116:163-175.
    • (1990) J Membr Biol , vol.116 , pp. 163-175
    • Musil, L.S.1    Beyer, E.C.2    Goodenough, D.A.3
  • 35
    • 0031172696 scopus 로고    scopus 로고
    • Gap junctions: Getting the message through
    • Nicholson SM, Bruzzone R. 1997. Gap junctions: Getting the message through. Curr Biol 7:R340-R344.
    • (1997) Curr Biol , vol.7
    • Nicholson, S.M.1    Bruzzone, R.2
  • 36
    • 0025630632 scopus 로고
    • Morphological study of intercellular junctions during osteocyte differentiation
    • Palumbo C, Palazzini S, Marotti G. 1990. Morphological study of intercellular junctions during osteocyte differentiation. Bone 11:401-406.
    • (1990) Bone , vol.11 , pp. 401-406
    • Palumbo, C.1    Palazzini, S.2    Marotti, G.3
  • 37
    • 0028120919 scopus 로고
    • Modulation of gap junction-mediated intercellular communication in embryonic chick mesenchyme during tissue remodeling in vitro
    • Parker SB, Hertzberg EL, Minkoff R. 1994. Modulation of gap junction-mediated intercellular communication in embryonic chick mesenchyme during tissue remodeling in vitro. Cell Tissue Res 275:215-224.
    • (1994) Cell Tissue Res , vol.275 , pp. 215-224
    • Parker, S.B.1    Hertzberg, E.L.2    Minkoff, R.3
  • 38
    • 0029143157 scopus 로고
    • New functions for gap junctions
    • Paul DL. 1995. New functions for gap junctions. Curr Opin Cell Biol 7:665-672.
    • (1995) Curr Opin Cell Biol , vol.7 , pp. 665-672
    • Paul, D.L.1
  • 41
    • 0032417994 scopus 로고    scopus 로고
    • Association of cell and substrate adhesion molecules with connexin 43 during intramembranous bone formation
    • in press
    • Rundus VR, Marshall GB, Parker SB, Bales ES, Hertzberg EL, Minkoff R. 1998. Association of cell and substrate adhesion molecules with connexin 43 during intramembranous bone formation. Histochem J (in press).
    • (1998) Histochem J
    • Rundus, V.R.1    Marshall, G.B.2    Parker, S.B.3    Bales, E.S.4    Hertzberg, E.L.5    Minkoff, R.6
  • 42
    • 0026746159 scopus 로고
    • Hormonal regulation of intercellular communication: Parathyroid hormone increases connexin 43 gene expression and gap-junctional communication in osteoblastic cells
    • Schiller PC, Mehta PP, Roos BA, Howard GA. 1992. Hormonal regulation of intercellular communication: Parathyroid hormone increases connexin 43 gene expression and gap-junctional communication in osteoblastic cells. Mol Endocrinol 6:1433-1440.
    • (1992) Mol Endocrinol , vol.6 , pp. 1433-1440
    • Schiller, P.C.1    Mehta, P.P.2    Roos, B.A.3    Howard, G.A.4
  • 43
    • 0030833934 scopus 로고    scopus 로고
    • Parathyroid hormone up-regulation of connexin 43 gene expression in osteoblasts depends on cell phenotype
    • Schiller PC, Roos BA, Howard GA. 1997. Parathyroid hormone up-regulation of connexin 43 gene expression in osteoblasts depends on cell phenotype. J Bone Miner Res 12:2005-2013.
    • (1997) J Bone Miner Res , vol.12 , pp. 2005-2013
    • Schiller, P.C.1    Roos, B.A.2    Howard, G.A.3
  • 46
    • 0023681306 scopus 로고
    • Cortical bone repair
    • Shapiro F. 1988. Cortical bone repair. J Bone Joint Surg 70:1067-1081.
    • (1988) J Bone Joint Surg , vol.70 , pp. 1067-1081
    • Shapiro, F.1
  • 47
    • 0030983903 scopus 로고    scopus 로고
    • Variable conformation of GAP junctions linking bone cells: A transmission electron microscopic study of linear, stacked linear, curvilinear, oval, and annular junctions
    • Shapiro F. 1997. Variable conformation of GAP junctions linking bone cells: A transmission electron microscopic study of linear, stacked linear, curvilinear, oval, and annular junctions. Calcif Tissue Int 61:285-293.
    • (1997) Calcif Tissue Int , vol.61 , pp. 285-293
    • Shapiro, F.1
  • 48
    • 0029608635 scopus 로고
    • The therapeutic potential of anti-sense oligonucleotides
    • Sharma HW, Narayanan R. 1995. The therapeutic potential of anti-sense oligonucleotides BioEssays 17:1055-1063.
    • (1995) BioEssays , vol.17 , pp. 1055-1063
    • Sharma, H.W.1    Narayanan, R.2
  • 49
    • 0022724174 scopus 로고
    • Prostaglandins change cell shape and increase intercellular gap junctions in osteoblasts cultured from rat fetal calvaria
    • Shen V, Rifas L, Kohler G, Peck WA. 1986. Prostaglandins change cell shape and increase intercellular gap junctions in osteoblasts cultured from rat fetal calvaria. J Bone Miner Res 1:243-249.
    • (1986) J Bone Miner Res , vol.1 , pp. 243-249
    • Shen, V.1    Rifas, L.2    Kohler, G.3    Peck, W.A.4
  • 50
    • 0013388927 scopus 로고    scopus 로고
    • Down-regulation of gap junctional intercellular communication between osteoblastic MC3T3-E1 cells by basic fibroblast growth factor and a phorbol ester (12-O-tetradecanoylphorbol-13-acetate)
    • Shiokawa-Sawada M, Mano H, Hanada K, Kakudo S, Kameda T, Miyazawa K, Nakamaru Y, Yuasa T, Mori Y, Kumegawa M, Hakeda Y. 1997. Down-regulation of gap junctional intercellular communication between osteoblastic MC3T3-E1 cells by basic fibroblast growth factor and a phorbol ester (12-O-tetradecanoylphorbol-13-acetate). J Bone Miner Res 12:1165-1173.
    • (1997) J Bone Miner Res , vol.12 , pp. 1165-1173
    • Shiokawa-Sawada, M.1    Mano, H.2    Hanada, K.3    Kakudo, S.4    Kameda, T.5    Miyazawa, K.6    Nakamaru, Y.7    Yuasa, T.8    Mori, Y.9    Kumegawa, M.10    Hakeda, Y.11
  • 52
    • 0031184124 scopus 로고    scopus 로고
    • Expression of connexin 43 in rat mandibular bone and periodontal ligament (PDL) cells during experimental tooth movement
    • Su M, Borke JL, Donahue HJ, Li Z, Warshawsky NM, Russell CM, Lewis JE. 1997. Expression of connexin 43 in rat mandibular bone and periodontal ligament (PDL) cells during experimental tooth movement. J Dent Res 76:1357-1366.
    • (1997) J Dent Res , vol.76 , pp. 1357-1366
    • Su, M.1    Borke, J.L.2    Donahue, H.J.3    Li, Z.4    Warshawsky, N.M.5    Russell, C.M.6    Lewis, J.E.7
  • 53
    • 15844394777 scopus 로고    scopus 로고
    • Gap junctional intercellular communication contributes to hormonal responsiveness in osteoblastic networks
    • Vander Molen MA, Rubin CT, McLeod KJ, McCauley LK, Donahue HJ. 1996. Gap junctional intercellular communication contributes to hormonal responsiveness in osteoblastic networks. J Biol Chem 271:12165-12171.
    • (1996) J Biol Chem , vol.271 , pp. 12165-12171
    • Vander Molen, M.A.1    Rubin, C.T.2    McLeod, K.J.3    McCauley, L.K.4    Donahue, H.J.5
  • 54
    • 0028025010 scopus 로고
    • Selective dye and ionic permeability of gap junction channels formed by connexin45
    • Veenstra RD, Wang H-Z, Beyer EC, Brink PR. 1994. Selective dye and ionic permeability of gap junction channels formed by connexin45. Circ Res 75:483-490.
    • (1994) Circ Res , vol.75 , pp. 483-490
    • Veenstra, R.D.1    Wang, H.-Z.2    Beyer, E.C.3    Brink, P.R.4
  • 56
    • 0026810757 scopus 로고
    • Gap junctions in development - A perspective
    • Warner A. 1992. Gap junctions in development - A perspective. Semin Cell Biol 3:81-91.
    • (1992) Semin Cell Biol , vol.3 , pp. 81-91
    • Warner, A.1
  • 57
    • 0028901331 scopus 로고
    • Structure-function relationships in gap junctions
    • Wolburg H, Rohlmann A. 1995. Structure-function relationships in gap junctions. Int Rev Cytol 157:315-373.
    • (1995) Int Rev Cytol , vol.157 , pp. 315-373
    • Wolburg, H.1    Rohlmann, A.2
  • 59
    • 0028858395 scopus 로고
    • Regulation of gap junction intercellular communication by pH in MC3T3-E1 osteoblastic cells
    • Yamaguchi DT, Huang JT, Ma D. 1995. Regulation of gap junction intercellular communication by pH in MC3T3-E1 osteoblastic cells. J Bone Miner Res 10:1891-1899.
    • (1995) J Bone Miner Res , vol.10 , pp. 1891-1899
    • Yamaguchi, D.T.1    Huang, J.T.2    Ma, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.