Genetic polymorphism at the CLOCK gene locus and major depression

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 96, Issue 3, 2000, Pages 418-421

  Desan, Paul H ^a,b   Oren, Dan A ^a,b   Malison, Robert ^b,c   Price, Lawrence H ^d   Rosenbaum, Jerrold ^e,f   Smoller, Jordan ^e,f   Charney, Dennis S ^b   Gelernter, Joel ^a,b  

^a VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Yale University School of Medicine and the Connecticut Mental Health Center   (United States)

^d BROWN UNIVERSITY   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Affective disorders; Behavioral genetics; Circadian rhythms; CLOCK gene; Genetic association; Single nucleotide polymorphism

Indexed keywords

GENE PRODUCT;

ALLELE; ARTICLE; CIRCADIAN RHYTHM; CLOCK GENE; CONTROLLED STUDY; DEPRESSION; GENE FREQUENCY; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

AFRICAN CONTINENTAL ANCESTRY GROUP; ALLELES; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CIRCADIAN RHYTHM; DEPRESSIVE DISORDER; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENE FREQUENCY; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; REPRODUCIBILITY OF RESULTS;

EID: 0034640696     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/1096-8628(20000612)96:3<418::AID-AJMG34>3.0.CO;2-S     Document Type: Article

References (30)

1. APA (American Psychiatric Association). 1994. American Psychiatric Association diagnostic and statistical manual of mental disorders, 4th ed. Washington, DC: American Psychiatric Press.
2. Cubells JF, Kobayashi K, Nagatsu T, Kidd KK, Kidd JR, Calafell F, Kranzler HR, Ichinose H, Gelernter J. 1997. Population genetics of a functional variant of the dopamine beta-hydroxylase gene (DBH). Am J Med Genet (Neuropsych Genet) 74:374-379.
3. Darlington TK, Wager-Smith K, Ceriani MF, Staknis D, Gekakis N, Steeves TDL, Weitz CJ, Takahashi JS, Kay SA. 1998. Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim. Science 280:1599-1603.
4. Desan PH, Oren DA. In press. Seasonal affective disorder: a circadian rhythm disorder? CNS Spectrum.
5. Drennan M, Shelby J, Kripke DF, Kelsoe J, Gillin JC. 1992. Morningness/eveningness is heritable. Soc Neurosci Abstr 18:196.
6. Duffy JF, Dijk DJ, Hall EF, Czeisler CA. 1999. Relationship of endogenous circadian melatonin and temperature rhythms to self-reported preference for morning and evening activity in young and old people. J Investig Med 47:141-150.
7. Dunlap J. 1998. An end in the beginning. Science 280:1548-1549.
8. First MB, Spitzer RL, Gibbon M, Williams JBW. 1997. Structured clinical interview for DSM-IV Axis I disorders. Washington, DC: American Psychiatric Press.
9. Gekakis N, Staknis D, Nguyen HB, Davis FC, Wilsbacher LD, King DP, Takahashi JS, Weitz CJ. 1998. Role of the CLOCK protein in the mammalian circadian mechanism. Science 280:1564-1569.
10. Gelernter J, Kranzler H, Cubells JF, Ichinose H, Nagatsu T. 1998a. DRD2 allele frequencies and linkage disequilibria, including the -141CIns/ Del promoter polymorphism, in European-American, African-American, and Japanese subjects. Genomics 51:21-26
11. Gelernter J, Kranzler H, Lacobelle J. 1998b. Population studies of polymorphisms at loci of neuropsychiatric interest (tryptophan hydroxylase (TPH), dopamine transporter protein (SLC6A3), D3 dopamine receptor (DRD3), apolipoprotein E (APOE), mu opioid receptor (OPRM1), and ciliary neurotrophic factor (CNTF)). Genomics 52:289-297
12. Gillin JC. 1983. The sleep therapies of depression. Prog Neuropsychopharmacol Biol Psychiatry 7:351-364.
13. Hall P, Spear MB, Stirland D. 1964. Diurnal variation of subjective mood in depressive state. Psychiatr Q 38:529-536.
14. Hastings M. 1998. The brain, circadian rhythms, and clock genes. Br Med J 317:1704-1707.
15. Hawkins DR, Mendels J. 1966. Sleep disturbance in depressive syndromes. Am J Psychiatry 123:682-690.
16. Hogenesch JB, Gu Y-Z, Jain S, Bradfield CA. 1998. The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc Natl Acad Sci USA 95:5474-5479.
17. Jones CR, Campbell SS, Zone SE, Cooper F, DeSano A, Murphy PJ, Jones B, Czajkowski L, Ptcek LJ. 1999. Familial advanced sleep phase syndrome: a short-period circadian rhythm variant in humans. Nat Med 5:1062-1065.
18. Katzenberg D, Young T, Finn L, Lin L, King DP, Takahashi JP, Mignot E. 1998. A CLOCK polymorphism associated with human diurnal preference. Sleep 21:569-576.
19. King DP, Zhao ZY, Sangoram AM, Wilsbacher LD, Tanaka M, Antoch MP, Steeves TDL, Vitaterna MH, Kornhauser JM, Lowry PL, Turek FW, Takahashi JS. 1997. Positional cloning of the mouse circadian Clock gene. Cell 89:641-653.
20. Kupfer DJ, Foster FG. 1972. Intervals between the onset of sleep and rapid-eye-movement sleep as an indicator of depression. Lancet 2:684-686.
21. Lewy AJ, Bauer VK, Cutler NL, Sack RL, Ahmed S, Thomas KH, Blood ML, Latham Jackson JM. 1998. Morning vs evening light treatment of patients with winter depression. Arch Gen Psychiatry 55:890-896.
22. Liebowitz MR, Quitkin FM, Stewart JW, McGrath PJ, Harrison WM, Rabkin J, Tricamo E, Markowitz JS, Klein DF. 1984. Phenelzine v. imipramine in atypical depression. Arch Gen Psychiatry 41:669-677.
23. Linkowski P, Van Onderbergen A, Kerkhofs M, Bosson D, Mendlewicz J, Van Cauter E. 1993. Twin study of the 24-h cortisol profile: evidence for genetic control of the human circadian clock. Am J Physiol 264:E173-E181.
24. Oren DA, Rosenthal NE. 1992. Seasonal affective disorders. In: Paykel E, editor. Handbook of affective disorders. Edinburgh: Churchill Livingstone. p 551-567.
25. Rosenwasser AM, Wirz-Justice A. 1997. Circadian rhythms and depression: clinical and experimental models. In: Redfern PH, Lemmer B, editors. Handbook of experimental pharmacology: physiology and pharmacology of biological rhythms, vol. 125. Heidelberg: Springer-Verlag. p 457-486.
26. Steeves TDL, King DP, Zhao Y, Sangoram AM, Du F, Bowcock AM, Moore RY, Takahashi JS. 1999. Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei. Genomics 57:189-200.
27. Sun ZS, Albrecht U, Zhuchenko O, Bailey J, Eichele G, Lee CC. 1997. RIGUI, a putative mammalian ortholog of the Drosophila period gene. Cell 90:1003-1011.
28. Tei H, Okamura H, Shigeyoshi Y, Fukuhara C, Ozawa R, Hirose M, Sakaki Y. 1997. Circadian oscillation of a mammalian homologue of the Drosophilia period gene. Nature 389:512-516.
29. Terman M, Terman JS, Ross DC. 1998. A controlled trial of timed bright light and negative air ionization for treatment of winter depression. Arch Gen Psychiatry 55:875-882.
30. Vitaterna MH, King DP, Chang A-M, Kernhauser JM, Lowrey PL, McDonald JD, Dove WF, Pinto LH, Turek FW, Takahashi JS. 1994. Mutagenesis and mapping of a mouse gene, clock, essential for circadian behavior. Science 264:719-725.