No association between catechol-O-methyltransferase (COMT) gene polymorphism and attention deficit hyperactivity disorder (ADHD) in an Irish sample

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 96, Issue 3, 2000, Pages 282-284

  Hawi, Ziarih ^a   Millar, Niamh ^a   Daly, Grainne ^a   Fitzgerald, Michael ^a   Gill, Michael ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Association; Attention deficit hyperactivity disorder (ADHD); Catechol O methyltransferase (COMT); Dopamine

Indexed keywords

CATECHOL METHYLTRANSFERASE;

ADOLESCENT; ADULT; ARTICLE; ATTENTION DEFICIT DISORDER; CHILD; FAMILY STUDY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HAPLOTYPE; HUMAN; IRELAND; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ADOLESCENT; ALLELES; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CATECHOL O-METHYLTRANSFERASE; CHILD; CHILD, PRESCHOOL; EPIDEMIOLOGY, MOLECULAR; FAMILY HEALTH; FEMALE; HUMANS; IRELAND; LINKAGE DISEQUILIBRIUM; MALE; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 0034640682     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/1096-8628(20000612)96:3<282::AID-AJMG9>3.0.CO;2-R     Document Type: Article

References (17)

1. Biederman J, Faraone SV, Keenan K, et al. 1992. Further evidence for family genetic risk factor in attention hyperactivity disorder patterns of comorbidity in probands and relatives in psychiatrically and paediatrically referred samples. Arch Gen Psychiatr 49:728-738.
2. Biederman J, Faraone SV, Mick E, Spencer T, Wilens T, Kiely K, Guite J, Ablon JS, Reed E, Warburton R. 1995. High risk for attention deficit hyperactivity disorder among children of parents with childhood onset of the disorder: a pilot study. Am J Psychiatr 152:431-435.
3. Cadoret RJ, Stewart MA. 1991. An adoption study of ADHD and aggression and their relationship to adult antisocial personality. Comprehen Psychiatr 32:73-82.
4. Daly G, Hawi Z, Fitzgerald M, Gill M. 1999. Mapping susceptibility loci in attention deficit hyperactivity disorder: preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children. Mol Psychiatr 4:192-196.
5. Garfinkel BD, Wender PH. 1989. Attention-deficit hyperactivity disorder. In Kaplan HI, Sadock BJ, editors. Comprehensive textbook of psychiatry. Baltimore: Williams and Wilkins. 1831 p.
6. Gill M, Daly G, Heron S, Hawi Z, Fitzgerald M. 1997. Confirmation of an association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism. Mol Psychiatry 2:311-313.
7. Giros B, Jaber M, Jones SR, Wightman RM, Caron RM. 1996. Hyperlocomotion and indifferences to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379:606-612.
8. Lachman H, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM. 1996. Human catechol-O-methyltransferase pharmacogenetics: description and functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6:243-250.
9. Lotta T, Vidgren J, Tilgmann C, Ulmanen I, Melen K, Julkunen I, Taskinen J. 1995. Kinetics of human soluble and membrane-bound catechol-O-metheyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 34:4202-4210.
10. Malone MA, Kershner JR, Swanson JM. 1994. Hemispheric processing and methylphenidate effects in attention deficit hyperactivity disorder. J Child Neurol 9:181-189.
11. Mynett-Johnson LA, Murphy VE, Claffey E, Shields DC, McKeon P. 1998. Preliminary evidence of an association between bipolar disorder in females and the catechol-O-methyltransferase gene. Psychiatr Genet 8: 221-225.
12. Sherman SL, DeFries JC, Gottesman II, Loehlin JC, Meyer JM, Pelias MZ, Waldman I. 1997. Behavioural Genetics 97: ASHG Statement. Recent development in human behavioural genetics: past accomplishment and future direction. Am J Hum Genet 60:1265-1275.
13. Silberg J, Rutter M, Meyer J, Maes H, Hewitt J, Siumonoff E, Pickles A, Loebber R, Eaves L. 1996. Genetic and environmental influence on the covariation between hyperactivity and conduct disturbance in juvenile twins. J Child Psychol Psychiatry 37:803-816.
14. Tannock R. 1998. Attention deficit hyperactivity disorder: advances in cognitive neurobiological, and genetic research. J Child Psychol Psychiatry 39:65-99.
15. Tenhunen J, Salminen M, Lundstrom K, Kiviluoto T, Savolainen R, Ulmanen I. 1994. Genomic organisation of the human catechol-O-methyltransferase gene and its expression from two distinct promoters. Eur J Biochem 223:1049-1059.
16. Thapar A, Holmes J, Poulton K, Harrington R. 1999. Genetic basis of attention and hyperactivity. Br J Psychiatry 174:105-111.
17. Ward MF, Wender PH, Reimherr FW. 1993. The Wender Utah Rating Scale: an aid in the retrospective diagnosis of childhood attention deficit hyperactivity disorder. Am J Psychiatry 150:885-890.