Human leucocyte antigen-A2 increases risk of Alzheimer's disease but does not affect age of onset in a Scottish population

Neuroscience Letters

Volumn 294, Issue 1, 2000, Pages 37-40

  Harris, J M ^a   Cumming, A M ^b   Craddock, N ^a   St Clair, D ^b   Lendon, C L ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Alzheimer's disease; Apolipoprotein E; Human leucocyte antigen

Indexed keywords

APOLIPOPROTEIN E; HLA A2 ANTIGEN; MEMBRANE PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; HUMAN; INCIDENCE; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; META ANALYSIS; ONSET AGE; POPULATION; PRIORITY JOURNAL; REGRESSION ANALYSIS; RISK; UNITED KINGDOM;

AGE DISTRIBUTION; AGE OF ONSET; AGED; ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; CASE-CONTROL STUDIES; COHORT STUDIES; FEMALE; GENE FREQUENCY; HLA-A2 ANTIGEN; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; RISK ASSESSMENT; SCOTLAND; SEX DISTRIBUTION;

EID: 0034634743     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01539-1     Document Type: Article

References (30)

1. HLA A2 allele is associated with age at onset of Alzheimer's disease
2. Association of the HLA-A2 allele with an earlier age of onset of Alzheimer's disease
3. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer disease meta analysis consortium
4. DNA typing for HLA class I alleles: I. Subsets of HLA-A2 and of -A28
5. HLA class II polymorphism: implications for genetic susceptibility to autoimmune disease
6. Alzheimer's disease and HLA
7. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI
8. A full genome scan for late onset Alzheimer's disease
9. A polymorphism in the presenilin 1 gene does not modify risk for Alzheimer's disease in a cohort with sporadic early onset
10. The possible role of the immune system in Alzheimer's disease
11. Non-relationship between the HLA system and the senile form of Alzheimer's disease
12. Frequency of HLA-A and B alleles in early and late-onset Alzheimer's disease
13. HLA-A2, or a closely linked gene, confers susceptibility to early-onset sporadic Alzheimer's disease in men
14. Evidence for association of HLA-A2 allele with onset age of Alzheimer's disease
15. Complete genomic screen in late-onset familial Alzheimer's disease
16. HLA antigens in Alzheimer's disease
17. Lack of association between Alzheimer's disease and histocompatibility antigens
18. A HLA and family study of Alzheimer's disease
19. Variable association of HLA-A2 in men with early-onset Alzheimer disease
20. No association between the HLA-A2 allele and Alzheimer disease
21. HLA antigens in senile dementia and multiple infarct dementia
22. Apolipoprotein E epsilon 4 allele is a risk factor for familial and sporadic presenile Alzheimer's disease in both homozygote and heterozygote carriers
23. Risk of Alzheimer's disease and duration of NSAID use
24. HLA antigens in Alzheimer's disease
25. Identifying complex disease genes, progress and paradigms
26. HLA-A distribution in Alzheimer's disease
27. Alzheimer disease: evidence for susceptibility loci on chromosomes 6 and 14
28. Histocompatibility antigens and antibodies to viral and other antigens in Alzheimer pre-senile dementia
29. Histocompatibility antigens in Alzheimer's disease. A preliminary study
30. On estimating the relation between blood group and disease