Frequency of HLA-A and B alleles in early and late-onset Alzheimer's disease

Neuroscience Letters

Volumn 262, Issue 2, 1999, Pages 140-142

  Middleton, D ^a,b   Mawhinney, H ^a   Curran, M D ^a   Edwardson, J A ^c   Perry, R ^c   McKeith, I ^c   Morris, C ^c   Ince, P G ^c   Neill, D ^c  

^a BELFAST CITY HOSPITAL   (United Kingdom)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c NEWCASTLE GENERAL HOSPITAL   (United Kingdom)

Author keywords

Alzheimer's disease; Apolipoprotein E; Dementia; HLA A; HLA B; MHC

Indexed keywords

DNA; HLA A ANTIGEN; HLA B ANTIGEN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; EXON; FEMALE; GENE AMPLIFICATION; GENE FREQUENCY; GENETIC POLYMORPHISM; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; OLIGONUCLEOTIDE PROBE; ONSET AGE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ADULT; AGE OF ONSET; AGED; AGED, 80 AND OVER; ALLELES; ALZHEIMER DISEASE; BRAIN; EXONS; FEMALE; GENE FREQUENCY; HLA-A ANTIGENS; HLA-B ANTIGENS; HUMANS; MALE; MATCHED-PAIR ANALYSIS; MIDDLE AGED; OLIGONUCLEOTIDE PROBES; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; STATISTICS;

EID: 0033525548     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00045-2     Document Type: Article

References (16)

1. Charron, D., Proceedings of the 12th International Histocompatibility Workshop and Conference, Vol. 1, 1997, pp. 817-820.
2. Corder E.H., Saunders A.M., Stritmatter W.J., Schmechel D.E., Gaskell P.C., Small G.W., Roses A.D., Haines J.L., Pericak-Vance M.A. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 261:1993;921-923.
3. Curran M.D., Middleton D., Edwardson J.A., Perry R.H., McKeith I., Morris C., Neill D. HLA-DR antigens associated with major genetic risk for late-onset Alzheimer's disease. NeuroReport. 8:1997;1467-1469.
4. Kappes D., Strominger J.L. Human class II major histocompatibility complex genes and proteins. Annu. Rev. Biochem. 57:1988;991-1028.
5. Kemper, T., Neuroanatomical and neuropathological changes in normal ageing and in dementia. In M.L. Albert (Ed.), Clinical Neurology of Ageing, Oxford University Press, Oxford, 1984, pp. 9-52.
6. Kendall E., Sargent C.A., Campbell R.D. Human major histocompatibility complex contains a new cluster of genes between the HLA-D and complement C4 loci. Nucleic Acids Res. 18:1990;7251-7257.
7. Levy-Lahad E., Bird T.D. Genetic factors in Alzheimer's disease: a review of recent advances. Ann. Neurol. 40:1996;829-840.
8. Middleton D., Williams F., Cullen C., Mallon E. Modification of an HLA-B PCR-SSOP typing system leading to improved allele determination. Tissue Antigens. 45:1995;232-236.
9. National Institute on Aging/Alzheimer's Association Working Group, Apolipoprotein E genotyping in Alzheimer's disease, Lancet, 347 (1996) 1091-1095.
10. Payami H., Schellenber G.D., Zareparsi S., Kaye J., Sexton G.T., Head M.A., Matsuyama S.S., Jarvik L.F., Miller B., McManus D.Q., Bird T.D., Katzman R., Heston L., Norman D., Small G.W. Evidence for association of HLA-A2 allele with onset age of Alzheimer's disease. Neurology. 49:1997;512-518.
11. Perry, R.H., Irving, D., Blessed, G., Fairbairn, A. and Perry, E.K., Senile dementia of Lewy body type: a clinically and neuropathologically distinct form of lewy body dementia in the elderly, J. Neurol. Sci., 95 (1990) 119-139.
12. Perry R.H., Irving D., Tomlinson B.E. Lewy body prevalence in the ageing brain relationship to neuropsychiatric disorders: Alzheimer type pathology and catecholaminergic nuclei. J. Neurol. Sci. 100:1990;223-233.
13. Rocca W.A., Hofman A., Brayne C., Bretleler M.M.B., Clarke M., Copeland J.R.M., Dartigues J.-F., Engedal K., Hagnell O., Heeren T.J., Jonker C., Lindesay J., Lobo A., Mann A.H., Molsa P.K., Morgan K., O'Connor D.W., Droux A.S., Sulkava R., Kay D.W.K., Amaducci L. Frequency and distribution of Alzheimer's disease in Europe: a collaborative study of 1980-1990 prevalence findings. Ann. Neurol. 30:1991;381-390.
14. Saunders A.M., Strittmatter W.J., Schmechel D., St. George-Hyslop P.H., Pericak-Vance M.A., Joo S.H., Rosi B.L., Gusella J.F., Crapper-MacLachlan D.R., Alberts M.J., Huletts C., Crain B., Goldgaber D., Roses A.D. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology. 43:1993;1467-1473.
15. Trowsdale J., Ragoussis J., Campbell R.D. Map of the human MHC. Immunol. Today. 12:1991;443-446.
16. Williams F., Mallon E., Middleton D. Development of PCR-SSOP for HLA-A typing of bone marrow registry donors. Tissue Antigens. 49:1997;61-66.