GABA(B) receptors. Role and therapeutic implications in CNS disorders

CNS Drugs

Volumn 7, Issue 3, 1997, Pages 167-175

  Bowery, Norman G ^a   Kerr, David I B ^b   Ong, Jennifer ^b  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOPROPYL(DIETHOXYMETHYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; BACLOFEN; BENZYL[3 [[1 (3,4 DICHLOROPHENYL)ETHYL]AMINO] 2 HYDROXYPROPYL]PHOSPHINIC ACID; CALCIUM; CGP 54626; PHACLOFEN; POTASSIUM; UNCLASSIFIED DRUG; [3 (3,4 DICHLOROBENZYLAMINO)PROPYL](DIETHOXYMETHYL)PHOSPHINIC ACID;

COGNITIVE DEFECT; DEPRESSION; EPILEPSY; HUMAN; PRIORITY JOURNAL; REVIEW; SPASTICITY; TRIGEMINUS NEURALGIA;

EID: 0030947047     PISSN: 11727047     EISSN: None     Source Type: Journal    
DOI: 10.2165/00023210-199707030-00001     Document Type: Review

References (93)

1. B sites in rat brain. Nature 1981; 290: 149-52
2. B receptor pharmacology. Annu Rev Pharmacol Toxicol 1993; 33: 109-47
3. B receptors. Pharmacol Ther 1995; 67: 187-246
4. Johnston GAR. GABA receptor pharmacology. In: Cuello AC, Collier B, editors. Pharmacological sciences: perspectives for research and therapy in the late 1990s. Basel: Publ. Birkhauser Verlag, 1995: 11-6
5. Bowery NG, Doble A, Hill DR, et al. Bicuculline-insensitive GABA receptors on peripheral autonomie nerve terminals. Eur J Pharmacol 1981; 71: 53-70
6. Bein HJ. Pharmacological differentiation of muscle relaxants. In: Birkmayer W, editor. Spasticity: a topical survey. Wien: Huber, 1972: 76-82
7. Keberle H, Faigle JW. Synthesis and structure-activity relationships of the γ-aminobutyric acid derivatives. In: Birkmayer JW, editor. Spasticity: a topical survey. Vienna: Hans Huber, 1972: 90-3
8. Muhyaddin M, Roberts PJ, Woodruff GN. Presynaptic γ-aminobutyric acid receptors in the rat anococcygeus muscle and their antagonism by 5-aminovaleric acid. Br J Pharmacol 1982; 77: 163-8
9. Anwar N, Mason DFJ. Two actions of γ-aminobutyric acid on the responses of the isolated basilar artery from the rabbit. Br J Pharmacol 1982; 75: 177-81
10. Jessen KR, Mirsky R, Dennison ME, et al. GABA may be a neurotransmitter in the vertebrate peripheral nervous system. Nature 1979; 281: 71-4
11. B-receptor-mediated modification of intestinal motility. Eur J Pharmacol 1983; 86: 9-17
12. Parkman HP, Stapelfeldt WH, Williams CL, et al. Enteric GABA-containing nerves projecting to the guinea-pig inferior mesenteric ganglion modulate acetylcholine release. J Physiol (Lond) 1993; 471: 191-207
13. B receptors in the central nervous system. Nature 1988; 332: 156-8
14. B blocker reduces long-duration inhibition in the neocortex. Eur J Pharmacol 1988; 148: 485-6
15. B receptors. Int Rev Neurobiol 1994; 36: 97-223
16. B receptors are coupled to a barium-insensitive outward rectifying potassium conductance in premotor respiratory neurons. J Neurophysiol 1993; 69: 286-9
17. B responses using patch-clamp recordings in rat hippocampal slices. J Physiol (Lond) 1993; 463: 391-407
18. Dolphin AC. G protein modulation of calcium current in neurons. Annu Rev Physiol 1990; 52: 243-55
19. B receptors and norepinephrine-stimulated cAMP production in rat brain cortex. Brain Res 1984; 306: 327-32
20. B receptor modulation of adenylate cyclase activity in rat brain slices. Br J Pharmacol 1985; 84: 249-57
21. Xu J, Wojcik WJ. Gamma aminobutyric acidB receptor-mediated inhibition of adenylate cyclase in cultured cerebellar granule cells: blockade by islet-activating protein. J Pharmacol Exp Ther 1986; 239: 568-73
22. 1-receptor-induced inositol phosphate formation in slices of rat cerebral cortex. J Neurochem 1988; 51: 1441-7
23. B receptor-mediated inhibition of 5-HT stimulated phosphotidylinositol turnover in mouse cerebral cortex [abstract]. Br J Pharmacol 1987; 90: 251P
24. Dolphin AC, McGuirk SM, Scott RH. An investigation into the mechanisms of inhibition of calcium channel currents in cultured sensory neurones of the rat by guanine nucleotide analogues and (-)baclofen. Br J Pharmacol 1989; 97: 263-73
25. B agonists. J Med Chem 1995; 38: 3297-312
26. Kerr DIB, Ong J, Prager RH, et al. Phaclofen: a peripheral and central bacloten antagonist. Brain Res 1987; 405: 150-4
27. Curtis DR, Gynther BD, Beattie DT, et al. Baclofen antagonism by 2-hydroxy-saclofen in the cat spinal cord. Neurosci Lett 1988; 92: 97-101
28. B antagonists. J Med Chem 1995; 38: 3313-31
29. B antagonists. Pharmacol Comm 1992; 2: 52-6
30. Bolser DC, Blythin DJ, Chapman RW, et al. The pharmacology of SCH 50911: a novel orally-active GABA-B receptor antagonist. J Pharmacol Exp Ther 1995; 274: 1393-8
31. Gemignani A, Paudice P, Bonanno G, et al. Pharmacological discrimination between γ-aminobutyric acid type B receptors regulating cholecystokinin and somatostatin release from rat neocortex synaptosomes. Mol Pharmacol 1994; 45: 558-62
32. B receptors. Trends Pharmacol Sci 1993; 14: 259-61
33. B receptor antagonists with similar potency: no evidence for pharmacologically different presynaptic receptors. Br J Pharmacol 1994; 113: 1515-21
34. +conductance of central neurons through different receptors [abstract]. Pharmacol Comm 1992; 2: 49
35. B receptors of rat neocorticat neurons differ in their pharmacological properties. Neuroscience Lett 1993; 154: 209-12
36. B receptors associated with cAMP production in rat brain. Brain Res. In press
37. Passariello N, Giugliano D, Torella R, et al. A possible role of γ-aminobutyric acid in the control of the endocrine pancreas. J Clin Endocrinol Metab 1982; 54: 1145-9
38. Calogero AE, Galluci WT, Chrousos GP, et al. Interaction between GABAergic neurotransmission and rat hypothalamic corticotropin-releasing hormone secretion in vitro. Brain Res 1988; 463: 28-36
39. B receptors intermedia demonstrated by release of αMSH caused by barium ions. Br J Pharmacol 1984; 82: 183-90
40. B receptors in excitation and inhibition of thalamocortical cells. Trends Neurosci 1991; 14: 16-21
41. B receptors. J Neural Trans Suppl 1992; 35: 155-77
42. Davies CH, Starkey SJ, Pozza MF, et al. GABA autoreceptors regulate the induction of LTP. Nature 1991; 349: 609-11
43. B receptor antagonists on long term potentiation. Naunyn Schmiedebergs Arch Pharmacol 1990; 342: 194-7
44. B receptors. Science 1991; 252: 1718-20
45. Isaacson JS, Solis JM, Nicoll RA. Local and diffuse synaptic actions of GABA in the hippocampus. Neuron 1993; 10: 165-75
46. Davies J. Selective depression of synaptic excitation in cat spinal neurones by baclofen: an ionophoretic study. Br J Pharmacol 1981; 72: 373-84
47. Barber RP, Vaughn JE, Saiton K. GABAergic terminals are presynaptic to primary afferent terminals; in the substantia gelatinosa of the rat spinal cord. Brain Res 1978; 141: 35-55
48. A receptor activation inhibits electrically evoked substance P-like immunoreactivity release from the rat spinal cord in vitro. J Pharmacol Exp Ther 1993; 266: 1490-6
49. Castro-Lopes JM, Tavares I, Tolle TR, et al. Increases in GABAergic cells and GABA levels in the spinal cord in unilateral inflammation of the hindlimb of the rat. Eur J Neurosci 1992; 4: 296-301
50. B receptor system. Br J Pharmacol 1994; 113: 1561-6
51. Bergamini L, Riccio A, Bergamasco B. Un farmmaco ad azione antispastica della muscolatura striata. Sperimentazione clinica di un derivato del GABA. Minerva Med 1966; 57: 2723-9
52. Birkmayer W, editor. Spasticity: a topical survey. Wien: Huber, 1972
53. Kiesswetter H, Schober W. Lioresal in the treatment of neurogenic bladder dysfunction. Urol Int 1975; 30: 63-71
54. Silber PL, Stolp-Smith KA. Intrathecal baclofen in tetanus: alternative methods of administration. Anesthesiology 1993; 79: 199-200
55. Milla PJ, Jackson ADM. A controlled trial of baclofen in children with cerebral palsy. J Int Med Res 1977; 5: 398-404
56. Penn RD, Savoy SM, Corcos D, et al. Intrathecal baclofen for severe spinal spasticity. N Engl J Med 1989; 320: 1517-21
57. Ochs G, Struppler A, Meyerson BA, et al. Intrathecal baclofen for long-term treatment of spasticity: a multi-centre study. J Neurol Neurosurg Psychiatry 1989; 52: 933-9
58. Lanzorthes Y, Sallerin-Caute B, Verdie JC, et al. Chronic intrathecal baclofen administration for control of severe spasticity. J Neurosurg 1990; 72: 393-402
59. Korsgaard S. Baclofen (Lioresal) in the treatment of neuroleptic-induced tardive dyskinesia. Acta Psychiatr Scand 1976; 54: 17-24
60. Paulson GW. Lioresal in Huntington's disease. Dis Nerv Syst 1976; 37: 465-7
61. Young RR, Delwaide PJ. Drug therapy-spasticity. N Engl J Med 1981; 304: 96-9
62. Jukes AM, editor. Baclofen: spasticity and cerebral pathology. Northampton: Cambridge Medical Publications, 1978
63. Schutter N, Verhaar HJ, Ottervanger JP. Intestinale pseudo-obstructie tijdens gebruik van baclofen. Ned Tijdschr Geneeskd 1995; 139: 1891-3
64. Penn RD, Kroin JS. Continuous intrathecal baclofen for severe spasticity. Lancet 1985; 2: 125-7
65. Penn RD. Intrathecal baclofen for severe spasticity. Ann N Y Acad Sci 1988; 531: 157-66
66. Delhaas EM, Brouwers JRBJ. Intrathecal baclofen overdose: report of 7 events in 5 patients and review of the literature. Int J Clin Pharmacol Ther Toxicol 1991; 29: 274-80
67. Smith DF. Stereoselectivity of spinal neurotransmission: effects of baclofen enantiomers on tail flick reflex in rats. J Neural Trans 1984; 60: 63-7
68. Thomas DA, Mcgowan MK, Hammond DL. Microinjection of baclofen in the ventromedial medulla of rats: antinociception at low doses and hyperalgesia at high doses. J Pharmacol Exp Ther 1995; 275: 274-84
69. Terrence CF, Potter DM, Fromm GH. Is baclofen an analgesic? Clin Neuropharmacol 1983; 6: 241-5
70. Geigy Pharmaceuticals Lioresal. In: Physician's Desk Reference. USA: Geigy, 1993; 1063-4
71. Fromm GH, Terrence CF, Chattha AS. Baclofen in the treatment of trigeminal neuralgia: double-blind study and long-term follow-up. Ann Neurol 1984; 15: 240-4
72. Mauskop A. Trigeminal neuralgia (tic douloureux). J Pain Symptom Manage 1993; 8: 148-54
73. Martins IP, Ferro JM. Atypical facial pain, ectasia of the basilar artery, and baclofen: a case report. Headache 1989; 29: 581-3
74. Dapas F, Hartman SF, Martinez L, et al. Baclofen for the treatment of acute low-back syndrome. A double-blind comparison with placebo. Spine 1985; 10: 345-9
75. Terrence CF, Fromm GH, Tenicela R. Baclofen as an analgesic in chronic peripheral nerve disease. Eur Neurol 1985; 24: 380-5
76. B agonist baclofen. Neuroscience 1995; 69: 345-9
77. Jensen N-H. Controlling all the pain all the time - the no pain concept. Postgrad Med J 1991; 67: 2-8
78. Bowery NG. Baclofen: 10 years on. Trends Pharmacol Sci 1982; 3: 400-3
79. Terrence CF, Fromm GH, Roussan MS. Baclofen: its effect on seizure frequency. Arch Neurol 1983; 40: 28-9
80. Rush JM, Gibberd FB. Baclofen-induced epilepsy. J R Soc Med 1990; 83: 115-6
81. May CR. Baclofen overdose. Ann Emerg Med 1983; 12: 171-3
82. Lipscomb DJ, Meredith TJ. Baclofen overdose. Postgrad Med J 1980; 56, 108-9
83. B receptor activation in area CA3 of rat hippocampus. Brain Res 1993; 600: 235-42
84. Mott DD, Bragdon AC, Lewis DV, et al. Baclofen has a proepileptic effect in the rat dentate gyrus. J Pharmacol Exp Ther 1989; 249: 721-5
85. B receptor antagonists: potential new anti-absence drugs. J Neural Transm 1992; Suppl. 35: 179-88
86. B receptor activation in absence seizures of lethargic (1h/1h) mice. Science 1992; 257: 398-401
87. B receptor blocker improves the cognitive performance of mice, rats and rhesus monkeys. Pharmacol Commun 1992; 2: 93-7
88. B receptors in the thalamus assessed by in vivo and in vitro experiments. Pharmacol Commun 1992; 2: 113-6
89. Ebenezer IS, Pringle AK. The effect of systemic administration of baclofen on food intake in rats. Neuropharmacology 1992; 31: 39-42
90. Allan AM, Harris RA. A new alcohol antagonist: phaclofen. Life Sci 1989; 45: 1771-9
91. File SE, Zharkovsky A, Gulati K. Effects of baclofen and nitrendipine on ethanol withdrawal responses in the rat. Neuropharmacology 1991; 30: 183-90
92. Breslow MF, Fankhauser MP, Potter RL, et al. Role of γ-aminobutyric acid in antipanic drug efficacy. Am J Psychiatry 1989; 146: 353-6
93. Krupitsky EM, Burakov AM, Ivanov VB, et al. Baclofen administration for the treatment of affective disorders in alcoholic patients. Drug Alcohol Depend 1993; 33: 157-63