Nonpeptide analogues of dynorphin A(1-8): Design, synthesis, and pharmacological evaluation of κ-selective agonists

Journal of Medicinal Chemistry

Volumn 43, Issue 16, 2000, Pages 2992-3004

  Ronsisvalle, G ^a   Pasquinucci, L ^a   Pittala, V ^a   Marrazzo, A ^a   Prezzavento, O ^a   Di Toro, R ^b   Falcucci, B ^b   Spampinato, S ^b  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; DYNORPHIN[1-8]; KAPPA OPIATE RECEPTOR AGONIST; N [[1 (5 AMIDINOBUTYLPENTYLCARBAMOYL) 3 METHYL BUTYLCARBAMOYL]METHYL] PHENYL [(8 HYDROXY DIMETHYL 1,2,5,6 TETRAHYDRO 4H 6 METHANOBENZAZAOCIN 3 YL)METHYL]CYCLOPROPANECARBOXAMIDE; N [[1 (6 AMIDINOBUTYLHEXYLCARBAMOYL) 3 METHYL BUTYLCARBAMOYL]METHYL PHENYL [(8 HYDROXY DIMETHYL 1,2,5,6 TETRAHYDRO 4H 6 METHANOBENZAZOCIN 3 YL)METHYL]CYCLOPROPANECARBOXAMIDE; NORBINALTORPHIMINE; OPIATE ANTAGONIST; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANALGESICS, OPIOID; ANIMALS; AZOCINES; BEHAVIOR, ANIMAL; CYCLOPROPANES; DYNORPHINS; MALE; MICE; MODELS, MOLECULAR; MOLECULAR MIMICRY; PAIN MEASUREMENT; PEPTIDE FRAGMENTS; RADIOLIGAND ASSAY; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034632912     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990356p     Document Type: Article

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