CoMFA-based prediction of agonist affinities at recombinant wild type versus serine to alanine point mutated D2 dopamine receptors

Journal of Medicinal Chemistry

Volumn 43, Issue 16, 2000, Pages 3005-3019

  Wilcox, R E ^a   Huang, W H ^a   Brusniak, M Y K ^a   Wilcox, D M ^a   Pearlman, R S ^a   Teeter, M M ^b   DuRand, C J ^b,c   Wiens, B L ^d   Neve, K A ^d  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b BOSTON COLLEGE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 5,6 DIHYDROXYTETRALIN; 2 DIPROPYLAMINO 7 HYDROXYTETRALIN; 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 3 O METHYLDOPAMINE; ALANINE; APOMORPHINE; BENZAZEPINE DERIVATIVE; BROMOCRIPTINE; BUTACLAMOL; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR STIMULATING AGENT; ERGOCRYPTINE; FENOLDOPAM; LISURIDE; PERGOLIDE; QUINPIROLE; SERINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; DOPAMINERGIC SYSTEM; DRUG RECEPTOR BINDING; GENE MUTATION; GLIOMA CELL; MOLECULAR MODEL; NEUROTRANSMISSION; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT;

ALANINE; AMINO ACID SUBSTITUTION; ANIMALS; BROMOCRIPTINE; COMBINATORIAL CHEMISTRY TECHNIQUES; DOPAMINE AGONISTS; MODELS, MOLECULAR; PERGOLIDE; POINT MUTATION; RADIOLIGAND ASSAY; RATS; RECEPTORS, DOPAMINE D2; RECOMBINANT PROTEINS; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0034632790     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990526y     Document Type: Article

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