Monoclonal antibodies to the hypervariable region 1 of hepatitis C virus capture virus and inhibit virus adsorption to susceptible cells in vitro

Virology

Volumn 269, Issue 2, 2000, Pages 276-283

  Zhou, Yi Hua ^a   Shimizu, Yohko K ^b   Esumi, Mariko ^a  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; MONOCLONAL ANTIBODY;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; DRUG BINDING; HEPATITIS C VIRUS; IMMUNIZATION; INFECTION CONTROL; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRUS ADSORPTION;

ANIMALIA; HEPATITIS C VIRUS;

EID: 0034630429     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2000.0227     Document Type: Article

References (21)

1. Ahmed M., Shikata T., Esumi M. Murine humoral immune response against recombinant structural proteins of hepatitis C virus distinct from those of patients. Microbiol. Immunol. 40:1996;169-176.
2. Booth J. C., Kumar U., Webster D., Monjardino J., Thomas H. C. Comparison of the rate of sequence variation in the hypervariable region of E2/NS1 region of hepatitis C virus in normal and hypogammaglobulinemic patients. Hepatology. 27:1998;223-227.
3. Esumi M., Ahmed M., Zhou Y.-H., Takahashi H., Shikata T. Murine anti-E2 and anti-hypervariable region 1 antibodies cross-reactively capture hepatitis C virus. Virology. 251:1998;158-164.
4. Esumi M., Rikihisa T., Nishimura S., Goto J., Mizuno K., Zhou Y.-H., Shikata T. Experimental vaccine activities of recombinant E1 and E2 glycoproteins and hypervariable region 1 peptides of hepatitis C virus in chimpanzees. Arch. Virol. 144:1999;973-980.
5. Farci P., Alter H. J., Wong D. C., Miller R. H., Govindarajan S., Engle R., Shapiro M., Purcell R. H. Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization. Proc. Natl. Acad. Sci. USA. 91:1994;7792-7796.
6. Farci P., Shimoda A., Wong D., Cabezon T., De Gioannis D., Strazzera A., Shimizu Y., Shapiro M., Alter H. J., Purcell R. H. Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein. Proc. Natl. Acad. Sci. USA. 93:1996;15394-15399.
7. Hijikata M., Kato N., Ootsuyama Y., Nakagawa M., Ohkoshi S., Shimotohno K. Hypervariable regions in the putative glycoprotein of hepatitis C virus. Biochem. Biophys. Res. Commun. 175:1991;220-228.
8. Hijikata M., Shimizu Y. K., Kato H., Iwamoto A., Shih J. W., Alter H. J., Purcell R. H., Yoshikura H. Equilibrium centrifugation studies of hepatitis C virus: Evidence for circulating immune complexes. J. Virol. 67:1993;1953-1958.
9. Kato N., Sekiya H., Ootsuyama Y., Nakagawa T., Hijikata M., Ohkoshi S., Shimotohno K. Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp 70) of hepatitis C virus. J. Virol. 67:1993;3923-3930.
10. Kumar U., Monjardino J., Thomas H. C. Hypervariable region of hepatitis C virus envelope glycoprotein (E2/NS1) in an agammaglobulinemic patient. Gastroenterology. 106:1994;1072-1075.
11. Ni Y. H., Chang M. H., Chen P. J., Hsu H. Y., Lu T. W., Lin K. H., Lin D. T. Decreased diversity of hepatitis C virus quasispecies during bone marrow transplantation. J. Med. Virol. 58:1999;132-138.
12. Puntoriero G., Meola A., Lahm A., Zucchelli S., Ercole B. B., Tafi R., Pezzanera M., Mondelli M. U., Cortese R., Tramontano A., Galfre G., Nicosia A. Towards a solution for hepatitis C virus hypervariability: Mimotopes of the hypervariable region 1 can induce antibodies cross-reacting with a large number of viral variants. EMBO J. 17:1998;3521-3533.
13. Shimizu Y. K., Hijikata M., Iwamoto A., Alter H. J., Purcell R. H., Yoshikura H. Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses. J. Virol. 68:1994;1494-1500.
14. Shimizu Y. K., Igarashi H., Kiyohara T., Cabezon T., Farci P., Purcell R. H., Yoshikura H. A hyperimmune serum against a synthetic peptide corresponding to the hypervariable region 1 of hepatitis C virus can prevent viral infection in cell cultures. Virology. 223:1996;409-412.
15. Shimizu Y. K., Purcell R. H., Yoshikura H. Correlation between the infectivity of hepatitis C virus in vivo and its infectivity in vitro. Proc. Natl. Acad. Sci. USA. 90:1993;6037-6041.
16. Weiner A. J., Brauer M. J., Rosenblatt J., Richman K. H., Tung J., Crawford K., Bonino F., Saracco G., Choo Q.-L., Houghton M., Han J. H. Variable and hypervariable domains are found in the regions of HCV corresponding to the Flavivirus envelope and NS1 proteins and the Pestivirus envelope glycoproteins. Virology. 180:1991;842-848.
17. Weiner A. J., Geysen H. M., Christopherson C., Hall J. E., Mason T. J., Saracco G., Bonino F., Crawford K., Marion C. D., Crawford K. A., Brunetto M., Barr P. J., Miyamura T., McHutchinson J., Houghton M. Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: Potential role in chronic HCV infections. Proc. Natl. Acad. Sci. USA. 89:1992;3468-3472.
18. Yoshikura H. Thermostability of human immunodeficiency virus (HIV-1) in a liquid matrix is far higher than that of an ecotropic murine leukemia virus. Jpn. J. Cancer Res. 80:1989;1-5.
19. Zhou Y.-H., Moriyama M., Esumi M. Multiple sequence-reactive antibodies induced by a single peptide immunization with hypervariable region 1 of hepatitis C virus. Virology. 256:1999;360-370.
20. Zibert A., Kraas W., Meisel H., Jung G., Roggendorf M. Epitope mapping of antibodies directed against hypervariable region 1 in acute self-limiting and chronic infections due to hepatitis C virus. J. Virol. 71:1997;4123-4127.
21. Zibert A., Schreier E., Roggendorf M. Antibodies in human sera specific to hypervariable region 1 of hepatitis C virus can block viral attachment. Virology. 208:1995;653-661.