Site-specific recombination in human cells catalyzed by phage λ integrase mutants

Journal of Molecular Biology

Volumn 296, Issue 5, 2000, Pages 1175-1181

  Lorbach, Elke ^a   Christ, Nicole ^a   Schwikardi, Micha ^a   Dröge, Peter ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Eukaryotes; Genomic engineering; Mutant recombinase; Site specific recombination; integrase

Indexed keywords

INTEGRASE; MUTANT PROTEIN; RECOMBINASE;

ARTICLE; BACTERIOPHAGE LAMBDA; CATALYSIS; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ESCHERICHIA COLI; GENE MUTATION; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

EID: 0034628887     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3532     Document Type: Article

References (13)

1. Alterations in the directionality of λ site-specific recombination catalyzed by mutant integrases in vivo
2. Site-specific recombination in mammalian cells expressing the Int recombinase of bacteriophage HK022
3. Dynamic, structural and regulatory aspects of lambda site-specific recombination
4. Mechanistic and structural complexity in the site-specific recombination pathways of Int and FLP
5. Purification and properties of Int-h, a variant protein involved in site-specific recombination by bacteriophage λ
6. Int-h: An int mutation of phage λ that enhances site-specific recombination
7. Ten years of gene targeting: Targeted mouse mutants, from vector design to phenotype analysis
8. Characterization of the interaction between the Lambda intasome and attB
9. Versatile eukaryotic vectors for strong and constitutive transient and stable gene expression
10. Site-specific recombination: Developments and applications
11. Architectural elements in nucleoprotein complexes: Interchangeability of specific and non-specific DNA binding proteins
12. The helical repeat of double-stranded DNA varies as a function of catenation and supercoiling
13. Suppression of the malignant phenotype in somatic cell hybrids between Burkitt's lymphoma cells and Epstein-Barr virus-immortalized lymphoblastoid cells despite deregulated c-myc expression