The cellular actions of β-adrenergic receptor agonists looking beyond cAMP

Circulation Research

Volumn 87, Issue 12, 2000, Pages 1079-1082

  Steinberg, Susan F ^a  

^a Columbia University ^*  (United States)

Author keywords

Apoptosis; cAMP; Mitogen activated protein kinases; Phosphatidylinositol 3' kinase; adrenergic receptors

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ADENYLATE CYCLASE; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; PERTUSSIS TOXIN; PROTEIN TYROSINE KINASE; RECEPTOR SUBTYPE; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BETA ADRENERGIC STIMULATION; CARDIOTOXICITY; DRUG MECHANISM; HEART FAILURE; HEART MUSCLE FIBROSIS; HEART PROTECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; REVIEW;

EID: 0034623867     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.87.12.1079     Document Type: Review

References (27)

1. Medical therapy can improve the biological properties of the chronically failing heart: A new era in the treatment of heart failure
2. 2-adrenergic receptor
3. 2-adrenergic receptor overexpression in mouse hearts: Critical role for expression level
4. 1-adrenergic receptor transgenic mice
5. 1-dependent coupling to phosphatidylinositol 3'-kinase
6. 2-adrenergic receptors on cardiac myocyte apoptosis role of a pertussis toxin-sensitive G protein
7. 2-adrenergic receptors hastens relaxation and mediates phosphorylation of phospholamban, troponin I, and C-protein in ventricular myocardium from patients with terminal heart failure
8. 2-adrenergic signal transduction
9. 2-Adrenergic receptors do not signal through pertussis toxin sensitive G proteins in neonatal rat ventricular myocytes
10. 1 dependent activation
11. The molecular basis for distinct β-adrenergic receptor subtype actions in cardiomyocytes
12. 1- and β-adrenergic receptors in mouse cardiomyocytes
13. 2+ in adult rat ventricular myocytes?
14. Differential targeting of β-adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae a mechanism to functionally regulate the cAMP signaling pathway
15. Both G(S) and G(L) proteins are critically involved in isoproterenol-induced cardiomyocyte hypertrophy
16. The Akt-glycogen synthase kinase 3β pathway regulates transcription of atrial natriuretic factor induced by β-adrenergic receptor stimulation in cardiac myocytes
17. Phosphatidylinositol 3-kinase stimulates muscle differentiation by activating p38 mitogen-activated protein kinase
18. Phosphoinositide 3-kinase induces the transcriptional activity of MEF2 proteins during muscle differentiation
19. The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyper-phosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase
20. Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway
21. β-Adrenergic pathway reduces apoptosis through calcineurin activation in cardiac myocytes
22. Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo an apoptosis-independent model of dilated heart failure
23. Apoptotic signaling through the β-adrenergic receptor a new G(s) effector pathway
24. Pharmacology of pertussis toxin B-oligomer
25. 2-adrenoceptor coupling to G(s)-, G(l)-, and G(q)-proteins
26. 2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure
27. 1-adrenergic receptor